Supplementary data: Characterization of medical device randomized controlled trials with adaptive designs by Gui Su (128698)

“…The average annual number of adaptive RCTs per 1000 clinical trials was the highest (8.55 ± 11.65) during 2005–2010, reduced to 3.33 ± 2.35 during 2011–2016, and significantly decreased to 1.29 ± 0.85 during 2017–2024 (p = 0.011). …”

Image 4_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …”

Table 1_Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.xlsx by Chuanchuan Wang (12228518)

“…Association analysis showed that all six SNPs were significantly associated with milk protein percentage. …”

Image 4_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Table 3_Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway.xlsx by Fan Lin (625737)

“…</p>Results<p>Polygonatum sibiricum polysaccharides significantly improved zebrafish swimming behavior, reduced blood glucose and fructosamine levels, and enhanced ATP production (p < 0.01). …”

Table 6_Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.xlsx by Chuanchuan Wang (12228518)

“…Association analysis showed that all six SNPs were significantly associated with milk protein percentage. …”

Image 3_HIV risk and influence factors among MSM who had sought sexual partners in core venues: a continuous sentinel surveillance in 2010–2022.png by Zijie Yang (6330086)

“…</p>Conclusion<p>Following the implementation of differentiated venue-based interventions, the risk of HIV among MSM who had sought sexual partners in core venues decreased to a level comparable to that of MSM who had not. …”

Experiences communicating in noise with aphasia (Harmon et al., 2024) by Tyson G. Harmon (11450904)

“…</p><p dir="ltr"><b>Results: </b>Quantitative findings showed that people with aphasia reported significantly greater perceived effort and stress than controls. …”

Data Sheet 4_Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway.... by Fan Lin (625737)

“…</p>Results<p>Polygonatum sibiricum polysaccharides significantly improved zebrafish swimming behavior, reduced blood glucose and fructosamine levels, and enhanced ATP production (p < 0.01). …”

Data Sheet 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.pdf by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …”

Table 1_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.docx by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …”

Table 1_Spatial yield gains in empty-row optimized rice–crab co-culture are linked to nifH-driven nitrogen compensation in border rows.docx by Tiexin Yang (21423032)

“…</p>Results<p>Our results showed that although ERC-12 increased per-plant yield via marginal effects in the boundary zone (PB), total yield decreased by 4.06%-5.20% compared to CK, primarily due to yield losses in the intermediate zone (PM) and empty rows. …”

Data Sheet 2_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.docx by Waner Wang (17773704)

“…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…”

Table 1_Tackling global inequalities in maternal hypertensive disorders: trends and the impact of public health emergencies, 1990–2021.csv by Siying Wei (5990276)

“…However, the pandemic significantly slowed the decline in low- and low-middle SDI regions.…”

Table 3_Patient-needs-enhanced emergency nursing assessment framework accelerates time-critical care for non-traumatic chest pain.docx by Yan Sun (22436)

“…</p>Conclusions<p>Augmenting ENAF with a structured clinical-needs module significantly accelerates ECG acquisition, improves other process metrics and enhances nursing documentation while maintaining patient safety. …”

Data Sheet 1_Mobility status, nutritional intervention and meal eaten are associated with discharge home: the nutritionDay study in China.docx by Bei Zhou (5219792)

“…Mobile patients who could walk unaided had a 1.2 to 1.3 times higher chance of discharge home and a significantly shorter duration of hospital stay after nutritionDay than those with reduced mobility, especially in patients receiving artificial nutrition (median: 8 days vs. 11 days, p < 0.001) and those with incomplete meal intake (median: 6 days vs. 8 days, p < 0.001). …”

Data Sheet 1_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.pdf by Waner Wang (17773704)

“…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…”

Image 5_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…The most common AEs in the PC group were blood toxicity related AEs (anemia, neutrophil count decreased, etc).</p>Conclusion<p>The PC therapy continues to provide a substantial survival benefit for patients with stage IIIb-IV NSCLC. …”

Table 1_Temporal trends and geographic disparities in thyroid cancer burden: a global analysis from 1990 to 2021.doc by Zuzhi Zhao (21724217)

“…</p>Conclusion<p>From 1990 to 2021, the global health burden of thyroid cancer increased significantly, with marked geographical disparities. …”

Image 3_Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty.tif by Shaolian Zang (11987905)

“…</p>Results<p>Hypothalamic GnRH and FTO expression progressively increased whereas m6A methylation decreased during puberty. MeRIP-seq revealed significantly reduced m6A methylation of Bdnf mRNA in the arcuate nucleus (ARC) of female rats during early puberty. …”