Riboflavin inhibits growth and reduces virulence of <i>Cryptococcus neoformans in vitro</i> by membrane disruption and excessive accumulation of reactive oxygen species and exhibit... by Jian Huang (7250)

“…Finally, in mouse models of intranasal and intravenous infection, RF treatment significantly reduced the fungal burden in multiple organs, reduced lung and brain damage, and decreased the levels of plasma interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-4 in the early stage of infection. …”

qorA associated data by fengning chen (20930834)

“…Consequently, the Δ<i>qorA</i> strain exhibited decreased levels of antioxidant enzymes such as superoxide dismutase and reduced pigment production. …”

Table 1_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Data Sheet 1_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.csv by Changsen Zhu (20821991)

“…Nonlinear regression revealed a U-shaped relationship between BCR and mortality: at BCR levels below 12.5, there was no significant correlation with long-term mortality; between 12.5 and 22, BCR appeared to exert a protective effect; and above 22, it emerged as a significant risk factor.…”

Table 5_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T... by Xinxin Ying (21507500)

“…Survival analysis revealed a significant correlation between elevated TIM-3 expression and decreased patient survival. …”

Table 3_Analysis of global trends in acute lymphoblastic leukemia in children aged 0–5 years from 1990 to 2021.docx by Fang Ding (222713)

“…</p>Findings<p>Between 1990 and 2021, the global number of childhood ALL cases increased by 59.06%, reaching 168,879 cases in 2021, while ALL-related deaths and DALYs decreased by 66.71% and 66.13%, respectively. High- and high-middle SDI regions demonstrated significant improvements, driven by advances in healthcare and early diagnosis. …”

Table 1_Detailed understanding of reduced geoeffectiveness of solar cycle 24 in association with geomagnetic storms.xlsx by R. Selvakumaran (21290378)

“…<p>Solar Cycle 24, the weakest in over a century, exhibited significant deviations from previous cycles, beginning with a prolonged minimum, weak polar fields, and asynchronous polar field reversal, leading to hemispheric asymmetry. …”

Table 2_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Data Sheet 1_Remarkable tumor response to Iruplinalkib in a 14-year-old girl with ALK-positive advanced metastatic non–small-cell lung cancer: a case report.pdf by Jiahao Wang (4710915)

“…Most metastatic lesions also showed significant regression. By six months, the pulmonary tumor had almost disappeared. …”

Supplemental data for "<b>Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury</b>" in Physiological Genomics by Kevin Burfeind (20421194)

“…In each dataset, we found that proximal tubule (PT) cells of the kidney undergo significant gene expression changes, with decreased expression of genes critically important for cell identity and function, indicative of dedifferentiation. …”

Image 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif by Jiaoli Xu (20871584)

“…Background<p>Congenital heart disease (CHD) is a leading cause of morbidity and mortality in children globally, with significant variations in outcomes across different regions.…”

Image 1_A case report: enhanced somatostatin receptor expression in metastatic pancreatic neuroendocrine tumor following everolimus therapy.pdf by Pei Zhang (232846)

“…However, therapeutic options become limited once SSTR expression decreases. This case report describes a 55-year-old man with grade 2 pNET who developed multiple liver metastases after undergoing pancreaticoduodenectomy in 2015. …”

Preliminary efficacy of eye movement desensitization and reprocessing for children aged 1.5–8 years with PTSD: a multiple baseline experimental design (<i>N</i> = 19) by Carlijn de Roos (8061239)

“…</p><p>The findings also show a significant reduction in emotional and behavioural problems as well as parenting stress.…”

Summary of this study. by Satoshi Hara (539722)

“…The numbers in parentheses indicate the reference numbers. Panels showing significant differences are highlighted. The arrows indicate increased or decreased. …”

Table1_Variation of leaf shape with tree size: a case study using Camptotheca acuminata Decne.xlsx by Ke He (331344)

“…However, DBH did not significantly affect the ratio W/L nor the leaf roundness index. …”

Spectral shift of fluorophore NHS-esters. by Hyunwoo Kim (690467)

“…After 5 min of illumination with a 561-nm excitation laser, the fluorescence signal in the 647-nm detection channel decreased, while the signal in the 561-nm detection channel significantly increased, indicating a spectral blue-shift of the emission spectrum. …”

Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies by Shazia Sofi (17764488)

“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”

Table 1_Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.docx by Juan Liu (6492)

“…Introduction<p>The emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.…”

C2CD3 regulates spatial organization of centriole architecture. by Eloïse Bertiaux (5309927)

“…<b>(C)</b> SAS6 length is significantly reduced in siC2CD3 (<i>n</i> = 28, 68 ± 25 nm) vs. siCTRL (<i>n</i> = 45, 104 ± 36 nm), ****<i>P</i> < 0.0001. …”