Supplementary Material for: Gut microbiome composition and one-year survival outcomes among patients with reduced ejection fraction heart failure by figshare admin karger (2628495)

“…Results: HFrEF patients showed a significantly lower abundance of all bacterial taxa, except for A. muciniphila. …”

DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx by Sayra J. Garcia (19748644)

“…</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …”

Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate <i>Staphylococcus aureus</i> pathogenicity by Shiyu Zhou (457967)

“…Our findings revealed that tanshinone I significantly inhibited vWbp-induced coagulation without affecting the proliferation of <i>S. aureus</i>. …”

Table 1_Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity.docx by Runqi Guo (22481293)

“…In vivo, MWA reshaped the tumor microenvironment by significantly increasing the intratumoral CD8+/Treg ratio (P<0.001), indicating a shift toward an anti-tumor inflammatory state. …”

Molecular basis for phenotype observed in <i>Cgulp2</i>Δ and STUbLs in <i>C</i>. <i>glabrata</i>. by Dipika Gupta (204889)

“…Based on the experimental validation of quantitative mass spectrometry data, ubiquitin-proteosome pathway, purine nucleotide biosynthesis pathway, and mitochondrial function were found to be significantly impacted in <i>Cgulp2ΔCgslx8Δ</i> double mutant. …”

Charged atomization characteristics and influencing factors analysis of aviation kerosene/ethanol blended fuel by Xiang Shao (1355631)

“…As the ethanol blending ratio increases, the critical voltage required for the transition to atomization mode decreases, while the atomization cone angle gradually increases. …”

Supplementary file 1_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx by Xuan Zhao (356028)

“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”

Table 1_Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis.docx by Shuting Li (6552)

“…In a murine model of peritoneal fibrosis induced by intraperitoneal injection of 4.25% PD fluid, SAL treatment significantly mitigated peritoneal fibrosis, as evidenced by reduced collagen deposition, decreased protein expression of α-smooth muscle actin and Collagen I, and a thinner peritoneum. …”

Data Sheet 5_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf by Qi Dong (119569)

“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”

Wheat germ agglutinin-nanoparticles encapsulating itacitinib target and suppress pro-inflammatory slan+ monocytes by Karen Alvarez (17620292)

“…ITA-loaded nanoparticles decreased HLA-DR, CD69, and CD86 expression, STAT1 phosphorylation, and cytokine production in IFN-γ-stimulated slan+ monocytes. …”

Image 1_Chito-oligosaccharide composites enhanced the adaptability of cotton seedlings to salinized soil by modulating photosynthetic efficiency and metabolite.tif by Mengjie An (9501175)

“…The results showed that salt stress reduced the contents of K⁺ and Ca²⁺ and enhanced the content of Na⁺ in cotton leaves compared to the control, which inhibited leaf photosynthesis and seedling growth. COS-PA application decreased leaf Na⁺ content significantly in salt-stressed cotton seedlings by 69.70%, and increased the leaf Ca²⁺ content, fresh weight of each plant part, transpiration rate, leaf chlorophyll concentration (Chl a), actual quantum yield, as well as stomatal conductance by 7.22%, 46.33%-96.36%, 96.65%, 44.53%, 27.15%, and 168.24%, respectively, compared with the no COS-PA application treatment. …”

Image 2_13C-CO2 pulse labelling evaluation of water deficit on leaf carbon dynamics and whole plant allocation in fruiting coffee.png by Janice Nakamya (21898532)

“…These were analysed to assess ¹³C enrichment in relation to carbon assimilation and leaf carbon changes over time. Water deficit significantly decreased carbon assimilation by 20-52% compared to well-watered plants, especially in young leaves (p< 0.05). …”

Supplementary file 6_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Data Sheet 1_Landscape analysis of m6A modification regulators reveals LRPPRC as a key modulator in tubule cells for DKD: a multi-omics study.docx by Li Jiang (120930)

“…Background<p>Diabetic Kidney Disease (DKD) is a serious complication of diabetes, imposing a substantial medical burden. The significance of N6-methyladenosine (m6A) modification in the pathogenesis of DKD has become increasingly prominent.…”

Supplementary file 2_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

<b>Astragalus polysaccharide and </b><b><i>Clostridium butyricum</i></b><b> synergistically inhibit bone loss in mice with humanized intestinal flora</b> by Hongtao Zhang (20774453)

“…We used a humanized intestinal flora mouse model and showed that APS-CB significantly inhibited bone loss caused by simulated weightlessness. …”

Data Sheet 1_SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing.docx by Chenxin Gan (22750214)

“…Using Cleavage Under Targets and Tagmentation (CUT&Tag) technology, we found that the binding affinity of NFIC decreases when SNP mutates from A to G, causing the reduced inhibition of NFIC on CD39 expression in T cells. …”

Candidate genes by Genome-wide CRISPR Screen. by Mingyi Xu (5575871)

“…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …”

Image 5_Isolation and identification of Alternaria alstroemeriae causing postharvest black rot in citrus and its control using curcumin-loaded nanoliposomes.jpeg by Jie Li (15030)

“…Curcumin-loaded nanoliposomes also enhanced the activities of the enzymes PPO, APX, POD, PAL, GR and CAT of citrus, decreased the O₂⁻ production rate. …”

RNA quality photo by zahra seifi (20804762)

“…Moreover, although the expression of the GRP78 gene increased in the sinus tissue of diabetic patients with mucormycosis, it significantly decreased in the same patients after treatment. …”