Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization by Yu-Xuan Yao (21338594)

“…Two-stage network MR analyses were conducted to assess the mediation effect of inflammatory proteins on the relationships between GLP1R agonists and kidney diseases.</p> <p>After meta-analyses of both discovery and validation cohorts, genetically proxied GLP1R agonist was found to significantly associated with a decreased risk of diabetic nephropathy (OR = 0.72, 95%CI = 0.54–0.97, <i>p</i> = 0.031) and IgA nephropathy (OR = 0.58, 95%CI = 0.36–0.94, <i>p</i> = 0.027). …”

Data Sheet 1_Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms.pdf by Monika Jürgenson (14030901)

“…</p>Results<p>It was demonstrated that co-administration of elocalcitol in the doses 15 ug/kg (i.p.) twice a week for 16 weeks prevented body weight gain by approximately 15%. …”

DataSheet1_Two-decade variability and trend of chlorophyll-a in the Arabian Sea and Persian Gulf based on reconstructed satellite data.docx by Mengmeng Yang (475288)

“…Rising SST anomalies (SST_A) correlated with reduced Chl-a anomalies (Chl-a_A) in the western AS, while increased wind anomalies (Wind_A) enhanced Chl-a_A in the western AS but decreased it in the southern PG. …”

Image6_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.jpeg by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Image3_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.jpeg by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Image4_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.jpeg by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Table3_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.docx by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Table2_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.docx by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Image5_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.jpeg by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Image2_Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.jpeg by Jie Han (128758)

“…In TaPIP1A knockout wheat strains, there was a significant decrease in stress tolerance, whereas Arabidopsis plants overexpressing TaPIP1A exhibited marked improvements in survival under similar stress conditions. …”

Baseline clinical data. by Lu-Jin Cheng (21743350)

“…In vitro experiments showed that the addition of Gal-9 led to a significant increase in the proportion of TIM-3⁺M1 and TIM-3⁺M2 macrophages and a decrease in M1 cell proportions and M1/M2 ratio. …”

DataSheet1_Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism.DOCX by Kangrui Hu (18718429)

“…Pharmacokinetic studies suggested that AHE modeling led to significant decrease in hepatic and cerebral exposure of GSH and cysteine. …”

Unraveling the Effects of Epigallocatechin-3-gallate on Hepatocellular Carcinoma Cells: A Comparative Analysis of Monolayer vs Multicellular Tumor Spheroids by Mariana dos Reis Simpronio (21876938)

“…We also evaluated the expression of genes related to cell survival and proliferation (<i>IL6</i>, <i>TNF</i>, <i>RELA</i>, <i>BAX</i>, <i>BCL2</i>), chromatin modification and DNA methylation (<i>EZH2</i>, <i>KDM1A</i>, <i>HAT1</i>, <i>DNMT3A</i>), and cell adhesion (<i>CDH1</i>, <i>CD44</i>, <i>ITGB2</i>, <i>MMP2</i>). …”

A spliced isoform of the retrotransposon <i>Copia</i> is enriched in neuronal tissue. by P. Githure M’Angale (20746093)

“…(F) Quantification of presynaptic α-Copia^gag normalized immunofluorescence and postsynaptic (G) intensity of the same. Quantification of <i>copia</i> mRNA in the larval CNS (H) and BWM (I) by digital PCR of strains used in this study showing a significant decrease of <i>copia</i> mRNA in lines with both the Gal4 driver and <i>copia</i> si/shRNA. …”

DataSheet1_RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn.DOCX by Kislay Roy (3466256)

“…The cytokine array analysis revealed that NaOH induced expressions of IL-1α and MMP-9, which were found to be significantly downregulated (1.8 and 11.5 fold respectively) by the combinatorial treatment of SurR9-C84A and TSA.…”

Spectral-domain optical coherence tomography (SD-OCT) images taken from a 72-year-old female patient with neovascular age-related macular degeneration (nAMD) who received ranibizum... by Zheyao Gu (20910794)

S1 Graphical abstract - by Hai Nguyen Ngoc Dang (19200560)

“…A longer diabetes duration was linked to a greater ASI (r = 0.43, p < 0.05), while the AS decreased (r = -0.37, p < 0.05).…”

This figure illustrates the impact of <i>Lactobacillus reuteri</i> supplementation on key indicators of colitis induced by dextran sulfate sodium (DSS). by Mohsen Nazari (6299819)

“…<b>(C)</b> Disease activity index (DAI) scores indicate a significant reduction in colitis severity in the <i>L. reuteri</i>-supplemented group. …”

Greening Fine Chemical Production via Continuous Flow Technology: An LCA-TEA-SA Integrated Assessment of <i>p</i>‑Nitrobenzoic Acid by Chen Feng (298683)

“…The key findings include the following: (1) CFT outperformed BWT with a 16.91% reduction in 100 year global warming potential, a 13.73% decrease in capital and operating expense, and a 1.5% improvement in overall safety score under real production conditions. (2) A trade-off model identified 154–160 °C as an optimal window where CFT excelled in environment-economy-temperature safety performance. …”

Greening Fine Chemical Production via Continuous Flow Technology: An LCA-TEA-SA Integrated Assessment of <i>p</i>‑Nitrobenzoic Acid by Chen Feng (298683)

“…The key findings include the following: (1) CFT outperformed BWT with a 16.91% reduction in 100 year global warming potential, a 13.73% decrease in capital and operating expense, and a 1.5% improvement in overall safety score under real production conditions. (2) A trade-off model identified 154–160 °C as an optimal window where CFT excelled in environment-economy-temperature safety performance. …”