Image1_Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.jpg by Alexis R. Steinmetz (18573319)

“…T-cells demonstrated upregulation of the immunogenic cell death signaling pathway and a decrease in the Th2 pathway genes. Macrophages showed upregulation of PD1/PD-L1 pathways along with downregulation of macrophage activation pathways (alternate and classical). …”

Presentation1_Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.pptx by Alexis R. Steinmetz (18573319)

“…T-cells demonstrated upregulation of the immunogenic cell death signaling pathway and a decrease in the Th2 pathway genes. Macrophages showed upregulation of PD1/PD-L1 pathways along with downregulation of macrophage activation pathways (alternate and classical). …”

Data Sheet 1_Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.pdf by Yaser Shabanpour (13247160)

“…Importantly, we found that DOX could penetrate the oxidized ferroptosis membrane with a lower free-energy barrier (∆G_PB) of approximately 38 kJ.mol⁻¹. …”

Table 1_Maintaining long-term frequent tea consumption could reduce the risk of cognitive decline: results from a 10-year longitudinal study.docx by Jie Huang (104235)

“…Consistently frequent tea drinkers had a 12% (HR:0.88, 95% CI: 0.77, 0.99) reduced risk of cognitive decline, whereas no significant association was observed for inconsistently frequent tea consumption (HR:0.98, 95% CI:0.91, 1.07) (P for trend < 0.001). …”

Data Sheet 1_Evaluating the efficacy of different doses of tocilizumab in treating critically ill COVID–19 patients: a single–center retrospective cohort study.docx by Jie Gao (10266)

“…</p>Results<p>After adjusting for potential confounders, there were no statistically significant differences in 30–day mortality (one dose vs. two doses HR 0.39; 95% CI, 0.15–1.04; P = 0.060 and one dose vs. three doses HR 0.27; 95% CI, 0.06–1.07; P = 0.067) or in–hospital mortality (one dose vs. two doses HR 0.65; 95% CI, 0.35–1.25; P = 0.090 and one dose vs. three doses HR 0.70; 95% CI, 0.40–1.50; P = 0.300) among the three groups. …”

Data Sheet 1_Immunolocalization and proteomic analyses of IZUMO1 in porcine spermatozoa.pdf by Miranda Hernández-Falcó (21373568)

“…As a result of the capacitation, there was a significant decrease in P1. …”

Table 1_MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study.docx by Shengbo Yang (295144)

“…Inflammatory markers (CRP, LPS) decreased with higher adherence (all p < 0.001). Each 1-unit increase in MIND diet score was significantly associated with reductions in fasting insulin (β = −0.20 μU/mL; p < 0.001), HOMA-IR (β = −2.11; p < 0.001), CRP (β = −2.12; p < 0.001), LPS (β = −8.52; p < 0.001). …”

Data Sheet 1_Grassland restoration impacts human-wildlife and social conflicts in the Chyulu Hills, Kenya.docx by Camila I. Donatti (8442690)

“…Results showed that 88.9% of the households interviewed experienced human-wildlife conflicts and 32% experienced social conflicts. There was a negative and significant correlation between the area restored in each site and both the number of human-wildlife conflicts and the number of social conflicts, showing that conflicts decrease as restoration increases. …”

Table 1_Ultrasonographic assessment of optic nerve sheath diameter on the affected and unaffected sides as a predictor of clinical deterioration at discharge in patients with large... by Changlan Li (704841)

Data Sheet 1_Psychological and cultural correlates of illness conception and menopausal symptoms: a cross-sectional and longitudinal comparative study of Mosuo, Yi, and Han women.p... by Limin Gao (760583)

“…Both the menopausal symptoms and the scores for concerns and fears about illness among Mosuo women significantly decreased in 2020 compared to 2012 (p = 0.040, p = 0.010).…”

Table 1_Decadal trends and regional disparities in tuberculosis burden: a comprehensive analysis of global, African, and Southeast Asian data from the GBD 1990–2021.docx by Shiwei Xie (3617159)

“…The annual percentage change (APC) was calculated to assess the significance of temporal trends.</p>Results<p>From 1990 to 2021, global age-standardized rates of TB declined markedly, with ASIR decreasing from 173.0 to 103.0 per 100,000, ASMR from 40.0 to 14.0, and ASDR from 1,650.6 to 580.3. …”

The number of sampling cercariae and snails affected the coverage of alleles. by Juan Long (4017317)

Long-term impact of molecular epidemiology shifts of methicillin-resistant <i>Staphylococcus aureus</i> on severity and mortality of bloodstream infection by Norihito Kaku (7439288)

“…<p>A 2019 nationwide study in Japan revealed the predominant methicillin-resistant Staphylococcus aureus (MRSA) types in bloodstream infections (BSIs) to be sequence type (ST)8-carrying SCC<i>mec</i> type IV (ST8-MRSA-IV) and clonal complex 1-carrying SCC<i>mec</i> type IV (CC1-MRSA-IV). …”

Data Sheet 1_The socio-cultural implications of glacier retreat demand further attention: a case study from Cerro El Plomo in Santiago, Chile.pdf by Kate Altemus Cullen (21487916)

Data Sheet 1_Comparison of adverse events between intensity-modulated radiation therapy and tomotherapy for early stage breast cancer: a retrospective cohort study.pdf by Yan Xia (534241)

“…A comparison of adverse events between the TOMO and IMRT groups showed no significant differences in localized edema, sore throat, tracheal mucositis, nausea, oral mucositis, and the IMRT groups. …”

<i>STAG2</i> mutant organoids display characteristics suggestive of increased crypt proliferation when cultured in differentiation media. by Wei Ni Yew (22439334)

“…In a similar way, <i>STAG2</i> mutant organoids also exhibited significantly decreased circularity (b) and increased crypt proliferation (c) compared with <i>STAG2</i> wildtype organoids. …”

Table 1_Association between red blood cell distribution width and encephalitis based on the pediatric intensive care unit database: a cross-sectional study.docx by Weichao He (16832265)

“…Multivariate regression models revealed that encephalitis in Chinese children was significantly decreased by 18% with 1% increase in RDW after adjusting for all covariates (Adjusted OR = 0.82, 95% CI: 0.73–0.92). …”

Supplementary file 1_Effects of Lactiplantibacillus plantarum DSM 33464 in children with elevated blood lead levels: a randomized, double-blind, placebo-controlled study.docx by Wenjing Ji (720509)

“…Probiotics, combined with a multivitamin/mineral supplement, significantly reduced the BLLs in these children within 12 weeks of supplementation by 40%, similar to that of the control group, which received a placebo plus multivitamin/mineral supplement. …”

Image 1_Association between red blood cell distribution width and encephalitis based on the pediatric intensive care unit database: a cross-sectional study.tif by Weichao He (16832265)

“…Multivariate regression models revealed that encephalitis in Chinese children was significantly decreased by 18% with 1% increase in RDW after adjusting for all covariates (Adjusted OR = 0.82, 95% CI: 0.73–0.92). …”

Data Sheet 1_Global, regional, and national burden of hyperglycemia-associated colorectal cancer, 1990-2021: a systemic analysis for the Global Burden of Disease study.zip by Yijuan Liu (5195747)

“…</p>Results<p>Globally, age-standardized rates (ASRs) of deaths, YLDs, YLLs, and DALYs attributed to hyperglycemia-associated CRC showed upward trends from 1990 to 2021, with YLDs exhibiting the highest consistent increase (EAPC = 1.47, 95% UI:1.35–1.60). Significant health disparities persisted across the 30 years, with higher burdens concentrated in high-socio-demographic index (SDI) regions. …”