Chordoma preclinical models are insensitive to BAF complex inhibitor FHD-286, alone or in combination with gemcitabine by Chordoma Foundation (4391989)

“…<p dir="ltr">To evaluate BRG1(SMARCA4)/BRM(SMARCA2) as a potential therapeutic target, chordoma cell lines were treated with FHD-286. …”

<b>Astragalus polysaccharide and </b><b><i>Clostridium butyricum</i></b><b> synergistically inhibit bone loss in mice with humanized intestinal flora</b> by Hongtao Zhang (20774453)

“…Specific mechanisms included that APS-CB increased the amount of short-chain fatty acids, especially butyric acid, in mouse feces, while increasing the abundance of Bacillariophyta (<i>Akkermansia</i>) in the intestine and decreasing the serum level of the bone resorption marker CTX-1. …”

Supplementary Tables S1 and S2 by Thomas Clanton (9323303)

“…In the second hour of exposure, though G-CSF, IL-6, KC(CXCL1) and MCP-1(CCL2) were elevated nearly 5-10-fold compared to the first hour, only MCP-1 decreased secretion in LyzMyd88^-/- muscles. …”

Spatial variation and clgassification of anthropogenic soils formed by long-term “<i>Dorotsuke”</i> soil-dressing in Andosols of the Omiya Upland along the Arakawa River, Japan by Shokichi Wakabayashi (3872428)

“…<p><i>Dorotsuke</i>, a traditional winter off-season farming practice in the Omiya Upland along the Arakawa River, involved transporting alluvial soil on horseback to the upland, maturing it, and then applying it to Andosol fields. …”

<b>Characterizing the role of PP2AB'' family subunits in mechanical stress response and plant development through calcium and ABA signaling in </b><b><i>Arabidopsis thaliana</i></b... by Hyuk Sung Yoon (19985262)

“…Transcriptome analysis showed a significant decrease in the expression of <i>CYP707A3</i>, a gene potentially targeted by VIP1 that regulates abscisic acid (ABA) catabolism, in the <i>atb''αβγδ</i> mutant compared to wild type leaves. …”

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of <i>Pseudomonas aeruginosa</i> in an organotypic 3D lung epithelial cell model by Merel Wauters (21333023)

“…Therefore, we determined the contribution of LasB to the observed reduction in cytokine levels by utilizing <i>P. aeruginosa lasB</i> knockout mutants. Compared to the <i>lasB</i> mutant, the wild-type strain significantly decreased inflammation by degrading MCP-1, IL-1β, GM-CSF, and IL-8. …”

Data Sheet 1_Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.pdf by Lei Xiang (528500)

“…</p>Results<p>ORes significantly reduces breast cancer cell viability and proliferation in a concentration-dependent manner, with IC₅₀ values of 104.8 μM, 150.2 μM, and 143.6 μM in MDA-MB-231, BT-549, and 4T1 cells, respectively. …”

DataSheet1_Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.pdf by Bo Yao (308010)

“…Furthermore, the drug significantly increased the mRNA and protein expression of PGC-1α and Sirt3 in aortic tissue, while decreasing the mRNA and protein expression of Epac1, Caspase-3, and Caspase-9.…”

DataSheet1_Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.pdf by Bo Yao (308010)

“…Furthermore, the drug significantly increased the mRNA and protein expression of PGC-1α and Sirt3 in aortic tissue, while decreasing the mRNA and protein expression of Epac1, Caspase-3, and Caspase-9.…”

<b>Social conditions alter the growth, metabolic rate, behavioral traits, and food-shelter preferences in the qingbo </b><b><i>Spinibarbus sinensis</i></b> by Yu-Lin Zhang (9129227)

“…These findings suggest that visual social isolation may not be a significant stressor for qingbo, as the isolation-reared qingbo exhibited improved growth. …”

An underlying mechanism of bovine mastitis: PGE₂ regulates <i>Staphylococcus aureus</i>-induced inflammatory response through TLR2, TLR4, and NLRP3 in macrophages by Shuangyi Zhang (21033650)

“…The bBMMs were treated with TLR2, TLR4, and NLRP3 inhibitors, which can decrease the expression of COX-2 and mPGES-1, further regulating PGE₂synthesis and secretion in <i>S. aureus </i>infection. …”

Alignment of the Taxane binding pocket sequences. by Jacopo Zattoni (21702634)

“…We found that the amoeba’s mitotic tubulins show a significant number of changes that are expected to decrease their affinity for tubulin-targeting compounds. …”

Table 1_Biomechanical mechanisms of multidirectional dynamic compensatory muscle fatigue induced by abnormal cervical curvature: a cross-sectional case-control study based on surfa... by Rui Yang (293531)

Single-driver controllability of brain networks. by Remy Ben Messaoud (20521877)

“…Colors code for different systems. Values are shown for a representative subject. By decreasing <i>r</i> all values become positive and numerically reliable after a critical threshold <i>r</i>*. …”

Methylation detection in the rDNA 28S gene body by MSP is robust and sensitive to methylation state of specific sites. by Stephen Flint Smith (22614954)

Supplemental Tables S1-S5 by Kevin Gries (21956942)

“…Utilizing a crossover design, subjects (n=9 [7M, 2F], 24±1y) exercised at 65% VO2max for 60-minutes following a day of reduced activity (IN; 3,581±1,185 steps) and normal activity (A; 11,069±3,631 steps). …”

Table 1_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Table 3_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Table 4_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”

Table 2_Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.docx by Nianfeng Tang (21536069)

“…In addition, the VD of the inferior parafoveal vein (P = 0.022) and superior parafoveal artery (P = 0.03) were significantly decreased in the NPDR group. Comparing the VD among NDR subgroups and control group, the VD of the superficial inferior parafovea of T1DM patients of early stage (less than 5 years) was significantly lower than that of normal people (p < 0.05), while the VD of the inferior parafoveal artery increased (P = 0.012).…”