Juvenile demyelination impairs the maturation of PV interneurons in the PFC. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0-650 pA current steps illustrating a significant decrease in PV interneuron firing frequency in cuprizone-treated mice. …”

Adult demyelination has no effect on PV interneuron’s firing rate or failures in autaptic responses. by Sara Hijazi (21656615)

Juvenile demyelination impairs autaptic plasticity. by Sara Hijazi (21656615)

Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…Summary data showing the averaged (± s.e.m) of the following intrinsic properties: (A) Resting membrane potential (RMP) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: *p < 0.05, **p < 0.01, ****p < 0.0001</i>), (B) Input resistance (IR) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0024, post-hoc LSD test: *p < 0.05, **p < 0.01, ***p < 0.001</i>), (C) Sag (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0083, post-hoc LSD test: *p < 0.05, **p < 0.01</i>), (D) Rheobase (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, p = 0.1230, post-hoc LSD test: *p < 0.05</i>) and (E) Action potential (AP) threshold (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, *p = 0.0452, post-hoc LSD test: *p < 0.05</i>), (F) AP half-width (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0058, post-hoc LSD test: **p < 0.01</i>), (G) Average action potential (AP) frequency in response to 0–650 pA current steps illustrating no significant change in S1 PV interneuron firing frequency following juvenile demyelination (<i>group x current two-way repeated measures: n = 36,30,19,24 cells from 9/8/8/6 mice per group: F(39,1,291) = 2.487, ****p < 0.0001</i>) and (H) Maximum firing frequency per group (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: ***p < 0.001, ****p < 0.0001</i>). …”

The UL4 null mutation alleviated inflammasome activation in PRV-infected cells. by Xiaohua Zhang (350570)

Viral UL4 protein promotes pyroptosis in macrophage cells. by Xiaohua Zhang (350570)

PRV UL4 also promotes AIM2-inflammasome activation. by Xiaohua Zhang (350570)

The UL4 null mutation alleviates inflammasome activation in PRV-infected cells. by Xiaohua Zhang (350570)

The UL4 mutation alleviates inflammasome activation and pyroptosis in PRV-infected cells. by Xiaohua Zhang (350570)

The UL4 mutation alleviated inflammasome activation and pyroptosis in PRV-infected cells. by Xiaohua Zhang (350570)

ssGSEA is employed to analyze immune infiltration in IS and OSA. by Zhe Wu (582498)

The UL4 mutation alleviated inflammation in PRV-infected mice. by Xiaohua Zhang (350570)

The UL4 mutation alleviates inflammation in PRV-infected pigs. by Xiaohua Zhang (350570)

Sequence of UL4 is involved in inflammasome activation. by Xiaohua Zhang (350570)

Data for Fig 6D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Data for Fig 5D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Effect of 1.25% of SCFP on MDR <i>Salmonella</i> serovars reduction at 24h. by Elena G. Olson (10649705)

Amorphous Silica/NaNbO₃ Crystal Heterophase Junction-Supported Ru Catalyst with Optimized Surface and Electron Structure for Highly Efficient Hydrogenation of α‑Pinene... by Haozhang Xu (21366415)

“…Optimizing supported catalysts through support improvement is a feasible approach to balance effectiveness and cost. …”

PRV UL4 augments ASC oligomerization and speck formation. by Xiaohua Zhang (350570)

PRV UL4 protein facilitates ASC oligomerization and speck formation by promoting ASC phosphorylation. by Xiaohua Zhang (350570)