Data Sheet 1_Aleurone supplementation enhances the metabolic benefits of training in Standardbred mares: impacts on glucose-insulin dynamics and gut microbiome composition.pdf by Berit Boshuizen (3747655)

“…</p>Results<p>Training alone: Training significantly improved OGTT parameters by decreasing Maximum_insulin (P = 0.005) and AUC_insulin (P = 0.001), while increasing Time to peak_insulin (P = 0.03), indicating enhanced insulin sensitivity. …”

Raw data for Figs 1, 2, 3, 4 and S2. by Areej A. Alfaifi (20422411)

“…Bulk RNA-sequencing of parotid salivary glands from COVID-19 autopsies demonstrated statistically significant decreased expression of histatin and amylase genes. …”

Data Sheet 1_Global, regional, and national burden of pneumococcal disease among children and adolescents aged <20 years from 1990 to 2021: a predictive analysis.docx by Gan-min Wang (21188933)

“…Background<p>Pneumococcal infections remain a leading cause of preventable deaths among children and adolescents aged <20 years. Despite a global decrease in burden, significant regional and socioeconomic disparities, as well as long-term trends, are not fully understood.…”

Table 1_Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry stud... by Zhongzhong Liu (111119)

“…Compared to Q1, the Q2 and Q4 groups showed significantly reduced risk in 1-year stroke recurrence (Q2: HR = 0.46, 95% CI 0.27 to 0.79, P = 0.005; Q4: HR = 0.47, 95% CI 0.27 to 0.81, P = 0.007), with a significant trend across all quartiles (P = 0.01 for trend tests). …”

Table4_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

JAK/STAT signaling can activate MMP expression. by Bente Winkler (20760273)

“…In pupal stages, <i>Mmp2</i> expression decreases significantly upon <i>STAT92E</i> downregulation and reaches control levels. …”

Image1_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.JPEG by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Table_1_Elevated serum albumin-to-creatinine ratio as a protective factor on clinical outcomes among critically ill patients with sepsis: a retrospective study.DOCX by Zhenkui Hu (11276526)

“…Background<p>The aim of this study was to examine the prognostic significance of serum albumin-to-creatinine ratio (ACR) in critically ill patients with sepsis.…”

Table_1_Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.X... by Hang Qian (444740)

“…From 1990 to 2019, the estimated global age-standardized incidence and mortality rates of MSMIs (AAPC: -1.32, 95% CI: −1.34 to −1.30; AAPC: -3.39, 95% CI: −4.28 to −2.48) in WCBA both demonstrated significant declining trends. The changing trends varied significantly across 6 regions and 204 countries. …”

Supplementary file 2_Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.docx by Ziao Liu (8938748)

“…Mechanistic investigations revealed that WZYZW markedly suppressed germ cell apoptosis (flow cytometry confirmed a significant decrease in apoptotic cell proportion) and attenuated DNA damage (indicated by significantly reduced γ-H2AX (a DNA damage marker) fluorescence intensity). …”

Table3_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Table 3_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.docx by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”

Table1_Microbe-immune interactions: new perspectives on coagulation deficiencies, purpura, and other hemorrhagic conditions under the regulation of the gut microbiota.xlsx by Ruhua Ren (19815546)

“…The mediating effect is opposite to the overall trend and has a relatively small impact. No significant heterogeneity or pleiotropy was observed.…”

Data Sheet 1_TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury.zip by Yunsheng Zhang (474242)

“…Background<p>Traumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. …”

Table 1_Revising cancer incidence in a Central European country: a Hungarian nationwide study between 2011–2019 based on a health insurance fund database.xlsx by Zoltán Kiss (5570003)

“…In 2018, the highest age-standardized incidence rates were found for lung (88.3), colorectal (82.2), and prostate cancer (62.3) in men, and breast (104.6), lung (47.7), and colorectal cancer (45.8) in women. The most significant decreases in incidence rates were observed for stomach (4.7%), laryngeal (4.4%), and gallbladder cancers (3.5%), with parallel decreases in mortality rates (3.9%, 2.7% and 3.2%, respectively).…”

Table2_Microbe-immune interactions: new perspectives on coagulation deficiencies, purpura, and other hemorrhagic conditions under the regulation of the gut microbiota.docx by Ruhua Ren (19815546)

“…The mediating effect is opposite to the overall trend and has a relatively small impact. No significant heterogeneity or pleiotropy was observed.…”

Image 5_The global burden of neonatal sepsis attributable to air pollution from 1990 to 2021: findings from the global burden of disease study 2021.jpeg by Jiajia Duan (9351878)

“…</p>Conclusion<p>Overall, air pollution remains a significant public health challenge threatening neonatal health. …”

Table_3_Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis.pdf by Yufei Wang (171069)

“…The written emotional disclosure intervention can decrease eating disorder symptoms scores (SMD = −0.20, 95% CI [−0.34, −0.05], Z = 2.59, p = 0.01), body dissatisfaction scores (SMD = 0.37, 95% CI [0.21, 0.52], Z = 4.59, p < 0.001), and thin ideal internalization score (SMD = 0.42, 95% CI [0.22, 0.62], Z = 4.12, p < 0.001). …”

Image_4_Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.J... by Hang Qian (444740)

“…From 1990 to 2019, the estimated global age-standardized incidence and mortality rates of MSMIs (AAPC: -1.32, 95% CI: −1.34 to −1.30; AAPC: -3.39, 95% CI: −4.28 to −2.48) in WCBA both demonstrated significant declining trends. The changing trends varied significantly across 6 regions and 204 countries. …”

Table 1_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.docx by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”