Data Sheet 8_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di... by Ying-han Deng (21604157)

“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”

Image 4_The global burden of hypertension and its epidemiological impacts on adolescents and young adults: projections to 2050.jpeg by Chaofeng Niu (17746406)

“…</p>Results<p>From 1990 to 2021, the absolute numbers of hypertension-related deaths, Disability-Adjusted Life Years (DALYs), and Years Lived with Disability (YLDs) increased significantly globally. The age-standardized mortality rate and DALY rate decreased to some extent, while the YLDs rate increased slightly. …”

Table 2_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Supplementary Material for: The role of reactive oxygen species in the pathogenesis of alopecia areata: a systematic review and meta-analysis. by Perlmutter J. (11590717)

“…Background: Alopecia areata (AA) is a T-cell-mediated autoimmune disease that significantly impacts patient quality of life. The breakdown of hair follicle immune privilege underlies AA pathogenesis. …”

Image 2_Exercise intolerance in patients with chronic coronary syndrome: insights from exercise stress echocardiography.tiff by Wei-wei Zhu (20349897)

“…An elevated peak EDVi/E/e’ and a decreased ΔSVi are independent risk factors for exercise intolerance in patients with CCS.…”

Data Sheet 2_Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with major depressive disorder in an in vitro fermentation model: a pilot study.xlsx by Yuwei Mi (18003969)

“…APS fermentation increased the abundance of Bifidobacterium and decreased the abundance of Lachnoclostridium (p < 0.05). …”

Assessment of soil erosion risks and prioritizing nature-based conservation practices using RUSLE, geospatial techniques and household surveys in central Ethiopia by Gamachu Yadata Nugusa (22683061)

“…The HHS and FO results align with the model findings, confirming that the SEHS decreases. These findings can inform policymakers, strengthen NBS, and guide targeted interventions. …”

Model comparison experimental results. by Chunhua Yang (346871)

“…The experimental results demonstrate that when compared to YOLOv10, S-YOLOv10-ASI shows significant improvements across various metrics. Specifically, Bounding Box Regression Loss decreases by over 30% in the training set, while Classification Loss and Bounding Box Regression Loss drop by more than 60% in the validation set. …”

DataSheet3_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…The decreased expression of Calbindin existed in both 12-week and 20-week old mice compared with control. …”

<b>Patterns</b><b> and drivers of </b><b>plant C:N:P stoichiometry</b><b> across a 3000 km aridity gradient</b> by Jianzhao Wu (19185964)

“…Below this threshold (AI < 0.7), the leaf C:P and N:P ratios decreased as AI increased, and N limitation became more evident. …”

Supplementary file 6_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…</p>Results<p>Our analysis revealed that the proportion of CCR7⁺ Tregs decreased as the disease advanced, while the cell proportion of HLA_DR⁺ regs escalated with the severity of the disease. …”

Image_2_Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.PNG by Weiran Lv (715679)

“…Introduction<p>Poor graft function (PGF), characterized by myelosuppression, represents a significant challenge following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with human cytomegalovirus (HCMV) being established as a risk factor for PGF. …”

Data Sheet 1_GLP-1 and glucagon receptor dual agonism ameliorates kidney allograft fibrosis by improving lipid metabolism.pdf by Linjie Peng (12553717)

“…Moreover, TB001 treatment decreased the body weight and serum total cholesterol, LDL-cholesterol, and TNF-α levels in transplant recipients, indicating metabolic improvements. …”

DataSheet1_Engineered myeloid precursors differentiate into osteoclasts and resorb heterotopic ossification in mice.docx by Cameron Rementer (20310858)

“…Once symptomatic, HO causes pain, limited mobility and decreased quality of life. Current treatments are limited and have significant complications with high recurrence rates, underscoring the need for improved therapeutic interventions. …”

Image 6_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.tif by Shirong Ruan (15414081)

“…</p>Results<p>We found ozone at a concentration of 30μg significantly alleviated mechanical hypersensitivity in CCI mice and ozone significantly upregulates the phagocytic activity of BMDM. …”

Supplementary file 1_Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.pdf by Yanling Wen (552195)

“…</p>Results<p>Our analysis revealed that the proportion of CCR7⁺ Tregs decreased as the disease advanced, while the cell proportion of HLA_DR⁺ regs escalated with the severity of the disease. …”

Data Sheet 1_Biorefinery—inspired, two-step valorization strategy to manage plant-based recalcitrant organic waste, involving solvent extraction, and fermentation with Bacillus cla... by Sreejith Meppoyilam (20563139)

“…The concentrated supernatant showed significant inhibition of Salmonella enterica and Shigella dysenteriae. …”

Data Sheet 1_Acupoint catgut embedding alleviates experimental autoimmune encephalomyelitis by modulating neuroinflammation and potentially inhibiting glia activation through JNK a... by Xiaofang Liu (398453)

“…In ACE-treated mice, EAE disease severity was significantly ameliorated, along with improvements in anxiety-like behaviors and reduced inflammation and demyelination. …”

Image 1_Body Mass Index mediates the associations between dietary approaches to stop hypertension and obstructive sleep apnea among U.S. adults.tiff by Songtao Li (186776)

“…</p>Conclusion<p>These findings suggested that DASH decreased OSA risk, which was possibly and partly mediated by BMI.…”

Image2_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…<p>The picocyanobacteria genera Prochlorococcus and Synechococcus play a significant role globally, dominating the primary production in warm and oligotrophic tropical and subtropical areas, which represent the largest oceanic ecosystem. …”