Supplementary file 5_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Image 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.tif by Yan Cheng (149222)

“…</p>Results<p>In PD models, the expressions of DHODH, MFN1, MFN2, GPX4, and FSP1 were significantly down-regulated, and their motor coordination, self-cognitive behavior, and exploration ability were decreased. …”

Table 1_Co-frequency or contrary? The effects of Qiwei Baizhu Powder and its bioactive compounds on mucosa-associated microbiota of mice with antibiotic-associated diarrhea.docx by Zeli Zhang (3422570)

“…The results showed that QWBZP-TG significantly altered the diversity, structure, and abundance of MAM in the AAD mice. …”

Table 1_LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis.docx by Yihan Liu (2258221)

“…</p>Results<p>OIP5-AS1 expression was significantly decreased in LUAD tissues and associated with poor survival. …”

Data Sheet 2_CqHKT1 and CqSOS1 mediate genotype-dependent Na+ exclusion under high salinity conditions in quinoa.pdf by Yasufumi Kobayashi (5481530)

“…By contrast, K⁺ accumulation was slightly reduced in the aerial parts but significantly decreased in the roots of all the genotypes. …”

Image 1_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.jpeg by Bing Gu (276393)

“…Administration of exogenous H₂S significantly improved anxiety and depression-like behavior, mitigated synaptic plasticity deficits, and activated the CREB/BDNF signaling pathway in the hippocampus of adolescent PTSD mice. …”

Image 2_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.tif by Asma Bibi (12057986)

“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”

Image 1_Study on the ecosystem service flow based on the relationship of between supply and demand in Yangtze River Economic Belt.jpeg by Ming Lei (161082)

“…The study of the supply of ecosystem services and the demand and consumption of ecosystem services by human society, and the analysis of the supply and demand characteristics and flow relationships of ecosystem service flows are of great significance for the management of regional ecosystems and the development of ecological compensation. …”

Image 2_Isolation and identification of Alternaria alstroemeriae causing postharvest black rot in citrus and its control using curcumin-loaded nanoliposomes.jpeg by Jie Li (15030)

“…Curcumin-loaded nanoliposomes also enhanced the activities of the enzymes PPO, APX, POD, PAL, GR and CAT of citrus, decreased the O₂⁻ production rate. …”

Data Sheet 1_Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone.pdf by Ning Sun (162468)

“…Co-occurrence network analysis showed that reclamation reduced interspecies interactions and significantly decreased network complexity, connectivity, and cohesion (P < 0.05). …”

The effect of Tawny crazy ants on the abundance of aboveground insect abundance in Texas by Ryan Reihart (9174179)

“…Additionally, areas were <i>N. fulva </i>were abundant had tended to have fewer grasshoppers from the Melanoplinae subfamily, which are likely decreasing in abundance due to direct predation and fleeing <i>N. fulva</i> abundant areas. …”

Data Sheet 1_Consistent microbial responses during the aerobic thaw of Alaskan permafrost soils.docx by Joy M. O’Brien (18927811)

“…Alpha diversity decreased with thaw across all sites, likely reflecting the increased dominance of specific thaw-responsive taxa that may be driving post-thaw biogeochemistry and increased respiration. …”

Data Sheet 1_Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells.doc by Koki Chiba (5413028)

“…Knockdown of PFKFB3 or pharmacological inhibition of glycolysis resulted in decreased insulin secretion and impaired glucose tolerance. …”

Data Sheet 1_Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.docx by Haifengqing Li (21575201)

“…In stroke rats, silencing ATF3 reduced brain water content, decreased neurological injury and alleviated cerebral infarction. …”

Table 2_Natural killer cell as a potential predictive biomarker for early immune checkpoint inhibitor-associated cardiovascular adverse events: a retrospective cohort study.docx by Yujuan Wu (2249857)

“…</p>Results<p>ScRNA-seq data revealed decreased CD8+ T and B cell proportions in the CVAEs group, while NK cell proportions increased. …”

Image 1_Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.jpeg by Ai-Li Xu (20622440)

“…Moreover, enforced GATA4 re-expression significantly counteracted the toxic effects of ATG5 on DOX-treated hearts. …”

Table 3_Efgartigimod for the treatment of immune checkpoint inhibitor-associated myocarditis complicated with impending crisis state of myasthenia gravis: a case report.docx by Mingjia Lu (21593324)

“…Treatment with efgartigimod (10 mg/kg) significantly improved myasthenic symptoms, with Myasthenia Gravis–Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores decreasing from 11 to 5 and 26 to 11, respectively. …”

Data Sheet 2_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.docx by Qi Dong (119569)

“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”

Data Sheet 1_LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis.docx by Yihan Liu (2258221)

“…</p>Results<p>OIP5-AS1 expression was significantly decreased in LUAD tissues and associated with poor survival. …”

Data Sheet 2_Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice.xlsx by Bing Gu (276393)

“…Administration of exogenous H₂S significantly improved anxiety and depression-like behavior, mitigated synaptic plasticity deficits, and activated the CREB/BDNF signaling pathway in the hippocampus of adolescent PTSD mice. …”