Data Sheet 2_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”

Table 4_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.docx by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

PTEN KD increases chromatin accessibility. by Ahmed H. Ghobashi (12705573)

“…Red dots indicate peaks with significantly increased or decreased accessibility with Log2 FC > |0.5|. …”

Data Sheet 1_Global, regional and national burden of decubitus ulcers in 204 countries and territories from 1990 to 2021: a systematic analysis based on the global burden of diseas... by Shenyue Zhang (18472266)

“…Background<p>Decubitus ulcers, also known as pressure ulcers, pose a significant public health challenge due to their substantial impact on morbidity, mortality, and healthcare expenditures.…”

Table 7_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Over the past 32 years, the average annual percentage change (AAPC) in the ASPR was statistically significant at −7.60% (t = −2.68, p < 0.05). Moreover, the annual percentage change (APC) in ASIR and ASPR showed the most significant decline from 2012 to 2015, with APCs of −70.47% (t = −3.01, p < 0.05) and − 66.55% (t = −14.94, p < 0.05), respectively.…”

Table 1_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.xlsx by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Image1_Causal effect of immune cells, metabolites, cathepsins, and vitamin therapy in diabetic retinopathy: a Mendelian randomization and cross-sectional study.png by Huijun Zhou (60485)

“…Cross-sectional data indicated that vitamins B1, B2, B6, B12, and E progressively decreased with DR severity.</p>Conclusion<p>This study is the first to identify CAT H as a key risk factor for DR, while vitamins B6 and E showed significant protective effects, particularly against PDR. …”

Data Sheet 2_Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization.docx by Yunbo Wu (9127390)

“…Localization analysis revealed decreased membrane-bound E-cadherin with increased cytoplasmic expression as lesion severity increased. …”

Table 7_Effects of silver nanoparticles on the physiology, stress, and mineral uptake of banana cultivars in vitro and greenhouse.xlsx by Natalia Mendoza (22038296)

“…Rooting experiments revealed similar trends with high AgNP concentrations resulting in a decreasing root number and size. Greenhouse experiments on Gros Michel bananas, evaluating AgNP uptake through foliar and drench applications at 0, 25, 50, and 100 mg L^-1, monitored over a month, showed no statistically significant differences in growth parameters between treated plants and controls. …”

Table 6_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Over the past 32 years, the average annual percentage change (AAPC) in the ASPR was statistically significant at −7.60% (t = −2.68, p < 0.05). Moreover, the annual percentage change (APC) in ASIR and ASPR showed the most significant decline from 2012 to 2015, with APCs of −70.47% (t = −3.01, p < 0.05) and − 66.55% (t = −14.94, p < 0.05), respectively.…”

Data Sheet 1_Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization.pdf by Yunbo Wu (9127390)

“…Localization analysis revealed decreased membrane-bound E-cadherin with increased cytoplasmic expression as lesion severity increased. …”

Table_5_Between-Subject and Within-Subject Variation of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest.pdf by Jonas Böcker (12116898)

“…The results showed that U_Meas decreased 59.3% to 80% over the two decades of bed rest studies (p < 0.01), and that it was higher for muscles than for bones. …”

Table 3_Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats.xlsx by Evan Fuini (21224939)

“…Treatment with psilocybin resulted in a significant dose-dependent increase in positive BOLD signal. …”

Table_1_Between-Subject and Within-Subject Variation of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest.pdf by Jonas Böcker (12116898)

“…The results showed that U_Meas decreased 59.3% to 80% over the two decades of bed rest studies (p < 0.01), and that it was higher for muscles than for bones. …”

Data Sheet 1_In vivo quantification of superficial cortical veins on susceptibility-weighted imaging with artificial intelligence image segmentation and the potential mechanism of... by Qi Xie (230608)

“…</p>Results<p>The quantitative value of SCV were significantly greater in males than in females. In higher age groups, the total number of SCVs and the number of SCVs in the left and right cerebral hemispheres significantly decreased. …”

Control analyses of behavioral timescales. by Isabel Raposo (21615517)

“…<p><b>(A)</b> Left: Randomly shuffling the time series data abolishes the signal autocorrelation; hence, removes the aperiodic temporal structure as indexed by decreasing timescales (<i>p</i> < 0.0001; <i>z</i>-scored relative to shuffled distribution). …”

Table 5_OSH45, a homeobox transcription factor, coordinates low-phosphate adaptation in rice.xlsx by Hong Lu (58784)

“…<p>Phosphorus (P), an essential macronutrient critical for plant growth and development, faces significant availability constraints in agricultural soils, substantially limiting crop yield potential. …”

Image 4_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Data Sheet 1_Transcriptome analysis of historic olives reveals stress-specific biomarkers.docx by Hamad A. Alkhatatbeh (21488114)

“…Proline levels remained stable in ‘Mehras’ but decreased under salinity stress in ‘Frantoio’, ‘Manzanillo’, and ‘Nabali’. …”

Data Sheet 1_Global burden, trends and inequalities of maternal hypertensive disorders among reproductive-age women of advanced maternal age, 1990–2021: a population-based study.pd... by Xuanyu Zhao (5881895)

“…</p>Conclusion<p>Despite overall declines in MHD burden, significant disparities persist, particularly in low SDI regions. …”