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41
Data Sheet 1_Clinical predictors and concomitant antiseizure medications effects on seizure control in relation to plasma cenobamate concentration: a multicenter retrospective stud...
Published 2025“…Although its mechanism of action is not fully understood, CNB enhances inhibitory GABAergic transmission and blocks voltage-gated sodium channels. Its non-linear pharmacokinetics and strong modulation of cytochrome P450 enzymes may significantly affect the metabolism of co-administered ASMs, posing important challenges for polytherapy management. …”
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42
The Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics
Published 2025“…Our results showed a linear <i>m</i>/<i>z</i> dependence for all enzymes, with Glu-C, Asp-N, and chymotrypsin requiring significantly lower energies than trypsin and Arg-C. …”
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43
Supplementary Material for: Global, regional, and national burden of brain and central nervous system cancers for males from 1990 to 2021 and its predicted level in the next 25 yea...
Published 2024“…Prevalence was assessed with DisMod-MR, trends via cluster analysis, and Estimated Annual Percentage Change (EAPC) calculated via linear regression. Forecasts for 2022-2044 used APC and BAPC models, with a P-value < 0.05 considered significant. …”
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44
Data Sheet 1_Acute effect of endurance exercise on human milk insulin concentrations: a randomised cross-over study.pdf
Published 2025“…We determined insulin concentrations in the milk using enzyme-linked immunosorbent assay and compared insulin concentrations after MICT and HIIT with REST using a linear mixed model with time-points and the interaction between time and condition as fixed factors.…”
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45
Table 1_Inverse association between triglyceride–glucose index and maximal oxygen uptake in US young and middle-aged population: a cross-sectional study.docx
Published 2025“…</p>Results<p>The complex sampling design and mobile examination center sample weights were considered. In multivariable linear regression analyses, each 1 unit increase in the TyG index was associated with a decrease in VO<sub>2</sub>max [β = −1.24, 95% CI (−1.97, −0.51), p = 0.002] when expressed as a continuous variable, independent of confounders. …”
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46
Image 2_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi...
Published 2025“…</p>Conclusion<p>Elevated consumption of diverse soy products exhibited a linear negative correlation with cognitive decline or major neurocognitive disorder; however, significant heterogeneity remained within both the overall analysis and multiple subgroup analyses.…”
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47
Table 1_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi...
Published 2025“…</p>Conclusion<p>Elevated consumption of diverse soy products exhibited a linear negative correlation with cognitive decline or major neurocognitive disorder; however, significant heterogeneity remained within both the overall analysis and multiple subgroup analyses.…”
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48
Image 1_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi...
Published 2025“…</p>Conclusion<p>Elevated consumption of diverse soy products exhibited a linear negative correlation with cognitive decline or major neurocognitive disorder; however, significant heterogeneity remained within both the overall analysis and multiple subgroup analyses.…”
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49
Table 1_Muscle quality index and hyperuricemia: adipose tissue as a mediator.docx
Published 2025“…MQI was calculated as the ratio of maximum handgrip strength to appendicular skeletal muscle mass (ASM), and adipose tissue parameters included body fat percentage (BF%) and visceral fat mass (VFM). To examine the link between MQI and hyperuricemia, multiple logistic regression models were employed, and generalized additive models were utilized to assess potential non-linear patterns. …”
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50
Table 2_Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry stud...
Published 2025“…Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR < 60 ml/min/1.73 m<sup>2</sup>, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).…”
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51
Table 1_Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry stud...
Published 2025“…Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR < 60 ml/min/1.73 m<sup>2</sup>, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).…”
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52
Table 3_Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry stud...
Published 2025“…Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR < 60 ml/min/1.73 m<sup>2</sup>, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).…”
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53
Table 1_The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: ev...
Published 2025“…Elevated NHHR levels in the Q2 and Q3 groups remained significantly linked to a decreased risk of advanced liver fibrosis, with odds ratios of 0.61 (95% CI 0.40–0.94, P = 0.03) and 0.64 (95% CI 0.47–0.89, P = 0.01), respectively. …”
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54
Table 5_The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: ev...
Published 2025“…Elevated NHHR levels in the Q2 and Q3 groups remained significantly linked to a decreased risk of advanced liver fibrosis, with odds ratios of 0.61 (95% CI 0.40–0.94, P = 0.03) and 0.64 (95% CI 0.47–0.89, P = 0.01), respectively. …”
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55
Table 4_The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: ev...
Published 2025“…Elevated NHHR levels in the Q2 and Q3 groups remained significantly linked to a decreased risk of advanced liver fibrosis, with odds ratios of 0.61 (95% CI 0.40–0.94, P = 0.03) and 0.64 (95% CI 0.47–0.89, P = 0.01), respectively. …”
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56
Table 2_The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: ev...
Published 2025“…Elevated NHHR levels in the Q2 and Q3 groups remained significantly linked to a decreased risk of advanced liver fibrosis, with odds ratios of 0.61 (95% CI 0.40–0.94, P = 0.03) and 0.64 (95% CI 0.47–0.89, P = 0.01), respectively. …”
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57
Table 3_The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: ev...
Published 2025“…Elevated NHHR levels in the Q2 and Q3 groups remained significantly linked to a decreased risk of advanced liver fibrosis, with odds ratios of 0.61 (95% CI 0.40–0.94, P = 0.03) and 0.64 (95% CI 0.47–0.89, P = 0.01), respectively. …”
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58
Data Sheet 1_Association of dietary index for gut microbiota and cardiovascular diseases in American adults: evidence from National Health and Nutrition Examination Survey 1999–201...
Published 2025“…Restricted cubic spline analysis showed a linear association between DI-GM and CVD. A significant mediating effect of BMI was observed (proportion of mediation: 16.27%, 95% CI: 9.11%−35.48%).…”
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59
Presentation 1_Germination responses of native fire ephemerals of Patagonian grasslands to smoke water and karrikinolide.zip
Published 2025“…Seeds collected on different harvest dates were incubated in a germination chamber, and germination responses were analyzed using Generalized Linear Models and Kaplan-Meier survival curves. KAR<sub>1</sub> significantly enhanced and accelerated germination in both species, with the strongest effect at the highest concentration (1/100). …”
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60
Table 1_Oxidative balance score is independently associated with reduced prevalence of sarcopenia among US adults with metabolic syndrome.docx
Published 2025“…Restricted cubic spline analysis confirmed that these relationships were linear. The impact of age was significant, with OBS benefits only observed in those aged 40 and older.…”