Data Sheet 2_Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.pdf by Yarou Gao (20620991)

“…In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. …”

Image 1_MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis.tif by Xincai Wang (7819064)

“…</p>Results<p>Bioinformatics analysis revealed significant downregulation of miR-27b in SCM cardiac tissues (log2FC=-3.9, P<0.001). …”

Table 2_GLP-1 and glucagon receptor dual agonism ameliorates kidney allograft fibrosis by improving lipid metabolism.docx by Linjie Peng (12553717)

“…Moreover, TB001 treatment decreased the body weight and serum total cholesterol, LDL-cholesterol, and TNF-α levels in transplant recipients, indicating metabolic improvements. …”

Table 1_Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain.xlsx by Safi Ullah (18598897)

“…Ambroxol treatment (30 mg/kg/day for 14 days) significantly reduced neuroinflammation and oxidative stress compared to LPS-treated mice. …”

Table 1_Impact of in-hospital COVID-19 quarantine policy changes on quality of acute stroke care: a single center experience.docx by Minkyung Kim (741928)

“…However, after accounting for potential confounders, a significant delay in DIT was found to be associated with the in-hospital COVID-19 quarantine policy.…”

Table 1_Differential brain activity in patients with disorders of consciousness: a 3-month rs-fMRI study using amplitude of low-frequency fluctuation.docx by Xuewei Qin (20426600)

“…Introduction<p>Disorders of consciousness (DoC) from severe brain injuries have significant impacts. However, further research on nuanced biomarkers is needed to fully understand the condition. …”

DataSheet3_Dissecting the importance and origin of circulating myokines in gastric cancer cachexia.xlsx by Marek Sierzega (3846406)

“…However, the analysis of paired samples failed to demonstrate a decreasing concentration gradient between the portal and peripheral blood for any of the myokines, evidencing against their release by the primary tumour. …”

Data_Sheet_2_Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.pdf by Weiran Lv (715679)

“…Introduction<p>Poor graft function (PGF), characterized by myelosuppression, represents a significant challenge following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with human cytomegalovirus (HCMV) being established as a risk factor for PGF. …”

Data Sheet 1_The impact of salt-tolerant plants on soil nutrients and microbial communities in soda saline-alkali lands of the Songnen plain.docx by Junjie Song (4400227)

“…Introduction<p>Soil salinization poses a significant threat to agricultural development and ecosystem health. …”

Image 1_Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response.tif by Jorgo Lika (21189020)

“…Treatment with these inhibitors also impacts neutrophil redox status, migration, and apoptosis without significantly changing overall bioenergetics.</p>Conclusions<p>Together, these results demonstrate that mitochondrial metabolism is dynamically remodeled and plays a significant role in neutrophils. …”

Data Sheet 1_5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation.pdf by Jinque Luo (9645983)

“…Introduction<p>Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a significant medical condition characterized by severe pulmonary inflammation and tissue damage. …”

Bacterium-Phage Symbiosis Facilitates the Enrichment of Bacterial Pathogens and Antibiotic-Resistant Bacteria in the Plastisphere by Rong Xia (30438)

“…The plastisphere phage community exhibited decreased diversity and virulent proportion compared to those found in environments. …”

miR-155 directly targets the 3′UTR of TRAF3 and STAT1. by Xinyue Zhang (271120)

“…<b>(F)</b> TRAF3 and STAT1 expression is decreased during the late phase of ALV-J infection. …”

Supplementary file 3_Impacts of Bacillus-based biotics and an enzyme cocktail on growth performance, immunity, and gut pathogenic microorganisms of nursery pigs under commercial co... by Seong-Min Koo (21788807)

“…</p>Results<p>The growth performance did not show significant differences according to the feed additives. …”

Table 1_Role of miR-144-5p in modulating lipid metabolism and potentially alleviating obesity via the PGC-1α/AMPK pathway.docx by Siriguleng Yu (14555900)

“…</p>Results<p>The treatment significantly reduced diet-induced adiposity and decreased inflammatory responses. …”

Table 9_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway by Qiuxia Liao (21507933)

“…Notably, all results were statistically significant. Overall, our findings revealed that dexmedetomidine may mitigate inflammation, oxidative stress, and renal dysfunction in mice with SAKI by upregulating the Pink1/Park2-mediated autophagy pathway. …”

Image 3_Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.tif by Shirong Ruan (15414081)

“…</p>Results<p>We found ozone at a concentration of 30μg significantly alleviated mechanical hypersensitivity in CCI mice and ozone significantly upregulates the phagocytic activity of BMDM. …”

ERICC Policy Brief_ Supporting children’s mental health and wellbeing in and through education in contexts of conflict and protracted crises by ERICC consortium (17060334)

“…., 2013), potentially decreasing attendance and retention rates as well as learning quality and continuity. …”

Data Sheet 4_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx by Shengyou Song (22391068)

“…The TGF-β/Smad signaling pathway plays a significant role in the development and progression of RCC.…”