Image 2_Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration.jpeg by Xiaohui Feng (2869535)

“…Combination treatment with Selinexor and DNR significantly increased apoptosis and DNA damage in vitro and reduced leukemia burden in zebrafish xenografts.…”

Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts by Yu-Tse Lee (19944891)

“…In vivo studies showed that overall tumor metastasis decreased in 4T1 xenografts mice treated with MSN-PEG/TA 25 with a notable reduction in lung tumor metastasis. …”

Data Sheet 1_Spleen tyrosine kinase inhibition mitigates radiation-induced lung injury through anti-inflammatory effects and downregulation of p38 MAPK and p53.pdf by Guoxing Zhang (4994213)

“…Syk was highly expressed in irradiated lung tissue, and fostamatinib inhibited the level of Syk expression. Syk inhibitor significantly alleviated the radiation-induced lung injury and downregulated the increased expression of p38 MAPK, p53, IL-1β, and IL-6 in lung tissue at 2 weeks after radiation. …”

Table 2_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.xlsx by Miguel Ângelo-Dias (20936444)

“…</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”

Table 1_Association between telomere length and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.docx by Feng Yang (132135)

“…</p>Results<p>Genetically determined longer telomere length was significantly associated with decreased risk of iNPH (OR = 0.44, 95% CI 0.24–0.80; p = 0.008). …”

Data Sheet 1_Oral immunotherapy for cow’s milk allergy in children: a systematic review and meta-analysis.docx by Yan Wang (15435)

“…The meta-analysis indicated that oral immunotherapy significantly facilitated desensitization in patients with cow’s milk allergy in children (relative risk [RR] 2.51, 95% CI: 1.54–4.09, I²=84.4%). …”

Data Sheet 1_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.csv by Ying Dong (41989)

“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”

Image1_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG by Wen Zhou (49050)

“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”

Supplementary file 1_The effect of development on cortical auditory evoked potentials in normal hearing listeners and cochlear implant users.docx by Eun Kyung Jeon (2032222)

“…</p>Results<p>Both onset and ACC responses were present across groups, with P1 latency decreasing significantly with age in NH and CI listeners. …”

Image 3_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff by José De Jesus Bravo-Silva (21898316)

“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”

Image 8_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif by Ying Dong (41989)

“…</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”

Table 1_Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mix... by Yong Han (111920)

“…The GAMM model revealed that PLT counts for patients who died were significantly lower and had a downward trend, while the survival group’s counts trended upward; the difference between the two groups generally exhibited an upward trend after admission, with a calculated average daily increase of 12.919 × 10⁹/L.…”

Supplementary file 1_Dynamic changes in peripheral inflammation as a risk factor for perioperative sleep disturbances in elderly patients undergoing laparoscopic hepatobiliary surg... by Lai Wei (36699)

“…Findings indicated that elevated NLR and SII levels before and after surgery, alongside decreased plasma IL-10 levels post-surgery, are associated with a higher incidence of PSD. …”

Table 4_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.xlsx by Miguel Ângelo-Dias (20936444)

“…</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”

Table 1_Factors influencing net ecosystem carbon change in cold-temperate coniferous forests of the Da Xing’an Mountains: analysis across developmental stages based on stand, struc... by Zirui Wang (8783819)

“…Stand age, shaped by population dynamics, disturbance regimes, and management practices, significantly influences the global carbon cycle. Although forest development is known to correlate with productivity shifts, how production varies across specific stand developmental stages and the relative contributions of driving factors remain poorly understood.…”

Table 10_Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation.xlsx by Linling Du (22827035)

“…RT-qPCR results confirmed that the expression levels of BTG2, DERL3, FOS, and HSPA13 were significantly upregulated, while YOD1 expression was downregulated in the PD group (P < 0.05), which was consistent with the database-predicted patterns.…”

Table 1_Dynamic changes in platelet counts and psychological state in ITP patients after COVID-19 infection.docx by Xiaoli Chen (102563)

“…The results showed that only in terms of low-grade fever, the proportion of ITP patients was significantly higher than that of healthy individuals, 31% vs. 17% (p = 0.04). …”

<b>Type 1 diabetes depends on CD4-driven expression of the transcriptional repressor, </b><b><i>Bcl6</i></b> by Dudley H. McNitt (20208081)

“…CD4-driven loss of functional BCL6 resulted in significantly reduced GC B cell and Tfh cell numbers in the pancreatic lymph nodes and pancreas at late pre-diabetic intervals. …”

Image 4_Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation.tif by Linling Du (22827035)

“…RT-qPCR results confirmed that the expression levels of BTG2, DERL3, FOS, and HSPA13 were significantly upregulated, while YOD1 expression was downregulated in the PD group (P < 0.05), which was consistent with the database-predicted patterns.…”

Data Sheet 1_Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.pdf by Shinn-Zong Lin (217003)

“…Key biochemical markers, including blood glucose, triglycerides, cholesterol, blood urea nitrogen (BUN), and creatinine, were significantly improved after treatment. Histopathologic analysis revealed restored renal morphology, reduced fibrosis and decreased amyloid deposition. …”