Data Sheet 1_Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.docx حسب Nikola Habek (21178259)

"…Background<p>Preclinical and clinical research of insulin resistance and glucose homeostasis in metabolic disorders are essential. In this study, we aim to determine the expression of uroguanylin (UGN) in the mouse and human brain, its regulatory mechanisms, and its significance to patients with obesity and type 2 diabetes (T2D).…"

Data_Sheet_1_Sleeping <6.55 h per day was associated with a higher risk of low back pain in adults aged over 50 years: a Korean nationwide cross-sectional study.PDF حسب Dexin Hu (19710271)

"…Each additional hour of sleep was associated with a 13.6% decrease in the risk of LBP. No significant association was observed between sleep duration ≥6.55 h and the risk of LBP. …"

Supplementary Material for: A New Era in the Management of Cardiorenal Syndrome: The Importance of Cardiorenal Units. حسب León-Román J. (20602337)

"…The purpose of this study is to evaluate the clinical performance of patients with CRS who are followed up by the Cardiorenal Unit (CRU). Methods: We conducted a retrospective observational study of patients referred to the CRU from April 1, 2022, to April 30, 2023. …"

Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture حسب Paul Yancey (14354982)

"…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …"

Table 1_Gut microbiota dysbiosis in ankylosing spondylitis: a systematic review and meta-analysis.docx حسب Qin-Yi Su (14188151)

"…In terms of specific microbial families, we observed a significant decrease in the abundance of Bifidobacterium (SMD = -0.42, 95% CI: -2.37, 1.52; P < 0.001), which is known for its beneficial effects on gut health. …"

Table 1_Case Report: Identification of a novel hemizygous CFAP47 variant in a primary ciliary dyskinesia patient with dual ciliary and flagellar defects.docx حسب Miao He (148269)

"…</p>Methods<p>We investigated a male patient with suspected PCD who exhibited “9 + 2” ultrastructural abnormalities in both bronchial cilia and sperm flagella. …"

Nationwide incidence and survival of retinoblastoma in the USA between 1996 and 2018: a review of 5730 cases حسب Ahmad Samir Alfaar (13998020)

"…A slight but significant annual decline in CIR was observed, with a trend toward an increase in the percentage of patients diagnosed in the first year of life.…"

Supplementary Material for: Hemispherotomy for Drug-Resistant Epilepsy in a Low-resource Setting: Surgical Outcomes and Quality of Life in 23 Children Treated in a Hybrid Program i... حسب figshare admin karger (2628495)

"…While hemispherotomy techniques and indications have evolved, access remains predominantly constrained to high resource settings. Methods: We performed a retrospective analysis of children who underwent hemispherotomy from 2011 to 2023 by a hybrid team, including local Panamanian and US neurologists, neurosurgeons and EEG technicians and analyzed surgical, epilepsy and quality of life (QoL) parameters. …"

Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis حسب Zhang Wen (6317543)

"…We found that different adipose parameters exhibited varying prognostic value: decreased subcutaneous adipose tissue index or muscle radiodensity, increased visceral-to-subcutaneous ratio, and concurrent myosteatosis or sarcopenic obesity were independently associated with a higher risk of mortality in patients with cirrhosis. …"

Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases حسب Xiaolong Liu (265696)

"…Cases 4 and 5 showed limited relief following a slight decrease in tumor size. In cases 2 and 6, no significant progression of the lesion was observed. …"

Data Sheet 1_A circular tri-trophic system incorporating plants, fish, and insects turns waste into a resource: case study with the cultivation of cucumber.docx حسب Efi Levizou (21298322)

"…Conversely, CAP resulted in a decline in nutrient levels in irrigation water relative to HP and DCAP, which led to significantly decreased leaf concentrations of potassium and phosphorus (2.5 and 1.5 times lower than HP, respectively, by the end of the experiment). …"

Supplementary Material for: Alcohol use and types and ischemic stroke: a systematic review and meta-analysis حسب figshare admin karger (2628495)

"…Conclusions: Our analysis provided a strong and robust evidence that there was a significant association between moderate and heavy alcohol use with ischemic stroke risk. …"

Deleterious Effects of a GAD65 Monoclonal Autoantibody on Islet Function حسب Christiane S. Hampe (248347)

"…<p dir="ltr">An intrinsic hallmark of Type 1 Diabetes is the correlation between appearance of autoantibodies directed against islet cell autoantigens with subsequent development of the disease. We recently studied effects of human monoclonal autoantibodies (mAb) derived from a pre-diabetic patient and demonstrated that a GAD65mAb penetrated and accumulated in beta cells and significantly reduced the insulin secretion rate (ISR). …"

Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses حسب Hyun Bong Park (1576939)

"…Here, we screened the supernatants from human fecal-derived bacterial cultures to explore their agonist effects on the human G protein-coupled receptors (GPCRs), melatonin receptor types 1A and 1B (MTNR1A, MTNR1B). …"

Bioclimatic variables used for MaxEnt modeling. حسب Dong-Joo Kim (1797640)

"…The findings indicate a general northward shift in climate suitability and a potential reduction in long-term suitable areas for all three species. …"

<b>Metabolic Improvements with Tirzepatide in Lipodystrophy: A Novel Option?</b> حسب Rasimcan Meral (5022425)

"…Here we hypothesize that tirzepatide, a dual incretin, may also lead to metabolic improvement in patients with lipodystrophy. …"

Repetitive stress induces a reduction in sound-evoked activity that develops as the stressor becomes chronic. حسب Ghattas Bisharat (20706928)

"…(b) Change in activity across sessions per tracked cell in response to 40, 60, and 70 dB white noise. We found a negative slope in most cells especially for mid-intensities, indicating a decrease in activity as the stress becomes chronic (<i>t</i> test for 40 dB <i>p</i> = 0.36, for 60 dB <i>p</i> = 9.3 × 10⁻¹², and for 70 dB <i>p</i> = 0.00750). …"

Selection flow chart of study participants. حسب Jiamin Yan (13214770)

"…</p><p>Methods</p><p>Utilizing a nationwide representative cohort from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015, we included 9,160 participants aged 45 years and older who did not have migraine at baseline. …"

Image 4_Structures and determinants of soil microbiomes along a steep elevation gradient in Southwest China.jpeg حسب Ting Li (117885)

"…The Simpson indices of both soil bacteria and fungi demonstrated a hollow trend along the elevational gradient, with an abrupt decrease in bacterial and fungal diversity at 2,600 m a.s.l. in coniferous and broad-leaved mixed forests (CBM). …"

Image 3_Structures and determinants of soil microbiomes along a steep elevation gradient in Southwest China.jpeg حسب Ting Li (117885)

"…The Simpson indices of both soil bacteria and fungi demonstrated a hollow trend along the elevational gradient, with an abrupt decrease in bacterial and fungal diversity at 2,600 m a.s.l. in coniferous and broad-leaved mixed forests (CBM). …"