Table 1_Exploring the alleviating effects of Bifidobacterium metabolite lactic acid on non-alcoholic steatohepatitis through the gut-liver axis.docx by Hongmei Zhao (250090)

“…</p>Results<p>In vivo findings indicated that, in comparison to CBX group (Control group without antibiotic treatment), NAFLD/CBX group (NAFLD group without antibiotic administration) and NAFLD/ABX group (NAFLD group with antibiotic administration) exhibited increased liver-to-body weight ratio, higher lipid droplet accumulation, aggravated liver histopathological damage, and elevated levels of AST (Aspartate Aminotransferase), ALT (Alanine Aminotransferase), TC (Total Cholesterol), TG (Triglycerides), LDL-C (Low-Density Lipoprotein Cholesterol), IL-6 (Interleukin-6), TNF-α (Tumor Necrosis Factor-alpha), IL-1β (Interleukin-1 beta), and NLRP3-related molecules, while HDL-C (High-Density Lipoprotein Cholesterol) levels significantly decreased. Intervention with Bifidobacterium significantly reversed these adverse changes. …”

Data Sheet 1_Dihydroartemisinin-sodium taurocholate-PLGA nanoparticles: a novel therapeutic approach against cystic echinococcosis.docx by Aierpati Moheteer (21522284)

“…Furthermore, the DSP nanoparticles-H group significantly decreased serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), direct bilirubin (DBIL), and alkaline phosphatase (ALP). …”

Table 3_To MRAs treatment or not? evidence from a meta-analysis of randomized controlled trials of different MRAs on cardiovascular health in heart failure.docx by Jinyu He (19774641)

“…Moreover, MRAs significantly improved LVEF (WMD = 1.384, 95% CI: 0.208–2.559, p = 0.021; I² = 59.9%). …”

Image 2_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif by Xinyu Sun (426009)

“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”

Table 1_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.xlsx by Xinyu Sun (426009)

“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”

Image 4_Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice.tif by Xinyu Sun (426009)

“…Notably, only the LV149-H significantly decreased the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while both doses increased the expression of the anti-inflammatory cytokine IL-10 in a dose-dependent in colonic tissue. …”

Image 1_Hypomethylation of GCNT2 isoform A correlates with transcriptional expression and is associated with poor survival in acute myeloid leukemia.tif by De-hong Wu (692691)

“…DNA methylation of GCNT2 showed a distinctive co-methylation pattern in AML and significantly negatively correlated with transcriptional expression. …”

Data Sheet 1_The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients.docx by Luigi Di Stolfo (21216599)

“…This inverse relationship correlated with greater average cell surface area in lower-density regions, while differences in the proliferation rates of the A549 cells at varying densities did not significantly impact uptake, did not significantly impact uptake.…”

Table 2_The germinal center-tertiary lymphoid structure after neoadjuvant chemo-immunotherapy for locally advanced lung squamous cell carcinoma can predict the disease progression.... by Lili Jiang (65114)

“…In addition, there was an inverted U-shaped correlation between GC-TLS and treatment cycle: the density of GC-TLSs reaches the peak value after receiving two or less (≤ 2) cycles of NACT and NACT-IO, and decreased significantly after receiving more than two (> 2) cycles of NACT and NACT-IO (p<0.05). …”

Table 3_The germinal center-tertiary lymphoid structure after neoadjuvant chemo-immunotherapy for locally advanced lung squamous cell carcinoma can predict the disease progression.... by Lili Jiang (65114)

“…In addition, there was an inverted U-shaped correlation between GC-TLS and treatment cycle: the density of GC-TLSs reaches the peak value after receiving two or less (≤ 2) cycles of NACT and NACT-IO, and decreased significantly after receiving more than two (> 2) cycles of NACT and NACT-IO (p<0.05). …”

White-to-opaque switching frequencies of double TF heterozygotes in a <i>WOR1</i>(KR-to-G) strain background. by Collin Ganser (8924843)

“…Double heterozygote strains that exhibited switching frequencies that were significantly higher than their expected switching frequencies (positive interactions) are shown in red and those significantly lower (negative interactions) are shown in blue (based on multiplying the switching frequencies of the corresponding single heterozygotes).…”

Data_Sheet_1_Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.docx by Xiaokang Niu (13839428)

“…</p>Results<p>Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. …”

RipU^K60 impacts actin cytoskeleton organization at 48 hours post infiltration. by Rachel Hiles (20477573)

“…(G,H) RipU^K60 significantly increased actin filament density (G), and decreased actin bundling (H) compared to controls at 48 hpi. …”

Image 2_Delineation of single-cell Altas provides new insights for development of coronary artery lesions in Kawasaki disease: bad and good signaling molecules.tif by Qiuping Lin (3091146)

“…In the monocytes of CAL patients, MCH-II is a significantly increased signal and RESISTIN is a significantly decreased signal compared to non-CAL counterpart.…”

Image 3_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Auditory brainstem response (ABR) thresholds were significantly elevated, and distortion-product otoacoustic emissions (DPOAE) indicated outer hair cell dysfunction. …”

Data Sheet 1_Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile.pdf by Wei Chen (23863)

“…</p>Results<p>UPLC-Q-TOF/MS identified 55 compounds in QRHSD. QRHSD significantly reduced clinical activity, histological changes, and inflammatory factors in UC mice, regulated Th17/Treg balance, and enhanced intestinal barrier integrity. 16S rRNA analysis showed that QRHSD altered gut microbiota composition, increasing beneficial bacteria (e.g., Lactobacillus) and decreasing harmful bacteria (e.g., Morganella). …”

Table_4_Effects of clear corneal incision location and morphology on corneal surgically induced astigmatism and higher-order aberrations after ICL V4c implantation.DOCX by Jun Wang (5906)

“…Anterior corneal SIA was significantly correlated to Dis-En and Dis-Ex in the superior CCI group. …”

Data Sheet 6_Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP+-induced neurological damage in the cellular model of Parkinson’s disease.zip by Chutian Zhang (10732350)

“…The serum effectively mitigated damage within the MAMs region and reduced both the mitochondrial-Ca²⁺ fluorescence intensity and the expression of the IP₃R-VDAC-MCU complex in MPP⁺-induced neuronal cells. Additionally, it significantly decreased the levels of ROS, the decline in MMP, and apoptosis rates in these cells.…”

Image 4_Temporal left ventricular ejection fraction variations and outcomes in wide population of cardiovascular patients with and without heart failure.tif by Radosław Szczerba (20837081)

“…In patients with HF, Kaplan–Meier survival curves showed significantly lower MACCE occurrence in HFimpEF and stable LVEF than in decreased LVEF (11.46%/year vs. 12.5%/year vs. 21.6%/year; log-rank p = 0.199 and p < 0.001) and HFimpEF constituted one of independent predictors of MACCE (HR = 0.84, 95% CI: 0.76–0.93). …”

Table 1_Working like a mule? The physiological toll of heavy loads on mules.docx by Tamara Tadich (17244898)

“…Conversely, glutathione peroxidase (GPx) activity decreased as load increased, implying increased oxidative demand. …”