Supplementary Material for: Association of MTHFR gene with type 2 diabetes mellitus: A case-control study and meta-analysis by figshare admin karger (2628495)

“…Results: In case-control study at the C677T(rs1801133), we found that compared with the AA genotype, GG + GA genotype was associated with an increased risk of T2DM (OR=1.605; 95% CI: 1.229–2.095; P=0.001); compared with the GG/GA genotype, AA genotype was associated with a decreased risk of T2DM (OR=0.620; 95% CI: 0.450–0.855; P=0.004; OR=0.625; 95% CI: 0.470–0.830; P=0.001). …”

Table 1_Immune checkpoint proteins are associated with persistently high liver stiffness after successful HCV treatment in people with HIV: a retrospective study.docx by Rubén Martín-Escolano (17411991)

“…Although LSM values showed a decreasing trend over the years following successful HCV treatment, this trend was not statistically significant due to substantial variability among PWH. …”

Causal associations between kidney function and aortic valve stenosis: a bidirectional Mendelian randomization analysis by Wanqian Pan (18147420)

“…In addition, the evidence did not support a significant causal association of AVS on kidney function.…”

Image 3_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.tif by Thibaud Dauphin (21196820)

“…Compared to a monolayer reference process, sEV yield decreased two-fold in SpF, but increased two-fold in STBr. …”

Image 1_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.tif by Thibaud Dauphin (21196820)

“…Compared to a monolayer reference process, sEV yield decreased two-fold in SpF, but increased two-fold in STBr. …”

Data Sheet 1_Understanding the long-term interplay of SARS-CoV-2 immune and inflammatory responses with proteases in COVID-19 recovery: a longitudinal study.pdf by Natalia Ćwilichowska-Puślecka (21515129)

“…Key findings include a decreasing deregulatory effect on immune responses exerted by subsequent SARS-CoV-2 variants Alpha, Delta, and Omicron.…”

Using insects for sustainable waste management of superabundant animals by Carlos Antonio Lopez Manzano (22371649)

“…We found that the BSF larvae can survive and complete its larval development in both 50% and 100% fecal treatment diets, albeit the growth rate, adult body weight, and adult lifespan decreased with increasing concentration of feces. …”

Image 2_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.tif by Thibaud Dauphin (21196820)

“…Compared to a monolayer reference process, sEV yield decreased two-fold in SpF, but increased two-fold in STBr. …”

Data Sheet 1_Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner.docx by Moriah R. Arnold (20908868)

“…</p>Methods<p>Our study created and characterized Snca knockout in the spontaneously developing melanoma TG3 mouse line, TG3+/+Snca-/-. </p>Results<p>We show that αSyn loss-of-function significantly delays melanoma onset and slows tumor growth in vivo in males. …”

Data Sheet 1_Sustainable remediation of heavy metal contaminated soil through phytostabilization with the in-situ immobilization by mercapto-based palygorskite.docx by Hongjie Kuang (22489438)

“…Compared with planting C. zizanioides alone, the application of MPAL significantly promoted the growth of C. zizanioides, enhanced its antioxidant enzyme activities, and decreased Cd and Pb concentrations in roots and shoots. …”

Impact of COVID-19 on early intervention referrals (Zellner et al., 2025) by Matthew A. Zellner (12043395)

“…</p><p dir="ltr"><b>Results: </b>Overall, we found large decreases in service provision rates for the first 2 timepoints; however, by September 2021, rates had moved closer to expected prepandemic levels. …”

Table 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.xlsx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). …”

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx by Sergey A. Gorbarenko (13696381)

“…Based on the constructed stack, we identified and categorized 15 notable Holocene centennial cooling events (HCCEs) in the NH (period with temperature decreases). …”

Table 1_Assessing the effects of the COVID-19 pandemic on new ART initiation and viral load access among children and adolescents living with HIV in West Africa: an interrupted tim... by Yao Rodion Konu (9617259)

“…Similarly, the number of VL tests performed decreased by 51% in Burkina Faso (IRR: 0.409 [0.253–0.662]). …”

Table 2_Sodium nitroprusside improves circulatory failure in rabbit acute pulmonary embolism combined with shock model possibly by enhancing NO release and inhibiting TLR4/NF-кB/HI... by Yuchan Zhou (10928151)

“…Pulmonary angiography showed that the mean pulmonary artery pressure increased significantly and the mean arterial pressure decreased significantly in the model group, which could be reversed by SNP treatment. …”

Data_Sheet_1_miR-124 Alleviates Ischemic Stroke-Induced Neuronal Death by Targeting DAPK1 in Mice.docx by Yan Shi (166398)

“…</p>Results<p>In vivo and in vitro results demonstrated that levels of miR-124 were significantly decreased following stroke, whereas changes in death-associated protein kinase 1 (DAPK1) levels exhibited the converse pattern. …”

Data Sheet 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…RNA-seq analysis revealed that the neutrophil and T cell activation and chemotaxis pathways were suppressed, and the infiltration of cytotoxic immune cells in the kidneys was decreased in the DNase I-treated group compared to MRL/lpr mice. …”

Table 1_Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression.xlsx by Fangmin Zhong (17415318)

“…</p>Results<p>Compared with normal samples, CML samples had significantly lower autophagy scores and more downregulated ARGs. …”

Image 1_Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.tif by Ali Jawad (1728757)

“…Myo-Ins supplementation also decreased the rate of apoptosis and the apoptotic index in the treatment groups. …”

Table 1_DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.docx by Manling Zhang (566460)

“…RNA-seq analysis revealed that the neutrophil and T cell activation and chemotaxis pathways were suppressed, and the infiltration of cytotoxic immune cells in the kidneys was decreased in the DNase I-treated group compared to MRL/lpr mice. …”