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significantly affect » significantly affected (Expand Search), significant effect (Expand Search), significant effects (Expand Search)
affect decrease » effects decreased (Expand Search), largest decrease (Expand Search)
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2581
Data Sheet 1_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.docx
Published 2025“…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …”
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2582
Table 1_Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.docx
Published 2024“…The experimental results showed that β-sitosterol could significantly inhibit the excessive proliferation of MH7A cells (p< 0.05). …”
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2583
Table 2_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.docx
Published 2025“…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …”
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2584
Data Sheet 2_Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance.pdf
Published 2025“…GO and KEGG analyses indicated that QgYp significantly affects TGF-β signaling pathway. In addition, the results of qPCR and Western blot analysis from both in vitro and in vivo experiments indicated that QgYp significantly downregulated the expression of proteins and mRNA associated with the TGF-β1/Smad2/3 pathway. …”
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2585
Data Sheet 1_Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.xlsx
Published 2024“…The experimental results showed that β-sitosterol could significantly inhibit the excessive proliferation of MH7A cells (p< 0.05). …”
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2586
GnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression
Published 2024“…</i> 56.1%, <i>p</i> < .001) in the GnRH-ant group were significantly decreased. Contrarily, the rate of early miscarriage in the GnRH-ant group (13.95% <i>vs.…”
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2587
Image 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf
Published 2025“…Functional studies employing CHMP4A-specific small interfering RNA (siRNA) revealed significant inhibition of malignant phenotypes in LIHC cells, notably affecting proliferation, migration, and invasive capabilities. …”
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2588
Table 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx
Published 2025“…Functional studies employing CHMP4A-specific small interfering RNA (siRNA) revealed significant inhibition of malignant phenotypes in LIHC cells, notably affecting proliferation, migration, and invasive capabilities. …”
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2589
Table 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx
Published 2025“…Functional studies employing CHMP4A-specific small interfering RNA (siRNA) revealed significant inhibition of malignant phenotypes in LIHC cells, notably affecting proliferation, migration, and invasive capabilities. …”
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2590
Image 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf
Published 2025“…Functional studies employing CHMP4A-specific small interfering RNA (siRNA) revealed significant inhibition of malignant phenotypes in LIHC cells, notably affecting proliferation, migration, and invasive capabilities. …”
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2591
Data Sheet 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx
Published 2025“…Functional studies employing CHMP4A-specific small interfering RNA (siRNA) revealed significant inhibition of malignant phenotypes in LIHC cells, notably affecting proliferation, migration, and invasive capabilities. …”
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2592
Data Sheet 1_Successional patterns of microbial communities across various stages of leaf litter decomposition in poplar plantations.pdf
Published 2025“…With the decomposition of leaf litter, the total N content increased gradually, while other nutrients (C, P, K, cellulose and hemicellulose) decreased progressively. Litter characteristics had significant effects on microbial community structure: C/N, TK and residual hemicellulose (RH) were the primary driving factors affecting fungal community structure, whereas bacterial community structure was influenced by TK, RH, residual cellulose (RC) and lignin contents.…”
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2593
DataSheet1_The Impact of Unmet Healthcare Needs on the Perceived Health Status of Older Europeans During COVID-19.pdf
Published 2024“…</p>Results<p>Findings indicate that unmet healthcare needs decreased throughout the pandemic but significantly contributed to the worsening of SRH among older adults. …”
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2594
Iron biofortification of <i>Pleurotus eous</i> via substrate supplementation
Published 2025“…Mycelial growth was suppressed at 60 mM, decreasing yield, while 45 mM recorded the maximum biological efficiency without affecting physical characteristics. …”
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2595
Paiva et al. data
Published 2024“…Pain assessment, clinical evaluation, and the measurement of heart rate (HR) and respiratory rate (RR) were conducted before and during ozone therapy. Ozone therapy significantly affected haemoglobin (F2,20=5.55; P=0.012), mean corpuscular haemoglobin concentrations (MCHC) (F2,20=16.01; P<0.001), and serum aspartate aminotransferase (AST) activity (F2,20=20.49; P<0.001). …”
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2596
Table 1_Association between Life’s Crucial 9 and metabolic dysfunction-associated steatotic liver disease: the mediating role of neutrophil-percentage-to-albumin ratio.docx
Published 2025“…In subgroup analyses, interaction tests showed that age, education, deprivation, obesity, smoking, hypertension, diabetes, and hyperlipidemia significantly affected the association between LC9 and MASLD (P for interaction < 0.05). …”
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2597
Table 1_Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021.docx
Published 2025“…Population growth and epidemiological changes contributed significantly to the increase in the burden of OUD.</p>…”
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2598
Table 1_Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target.docx
Published 2025“…Introduction<p>Bone metastases are a common and severe complication in advanced breast cancer, affecting approximately 65% to 70% of patients and significantly reducing survival time. …”
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2599
Data Sheet 1_Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.docx
Published 2025“…Gut microbiota associated with SBAs metabolism were significantly reduced, leading to decreased intestinal deoxycholic acid (DCA) and lithocholic acid (LCA). …”
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2600
Table 1_Ferula (Ferula elaeochytris) as a phytoestrogen: Use of Ferula in laying hens.docx
Published 2025“…TBARs value decreased in FRP-1 and FRP-2 groups. Serum triglyceride and cholesterol levels decreased in group FRP-2. …”