Supplementary Material for: From childhood to adolescence: Long-term trends in severe obesity in German youth (2002–2023) حسب figshare admin karger (2628495)

"…Results Pre-pandemic, SO remained stable or declined in children under 12 until 2010: OR5: 0.8-1, p<0.001) but rose significantly afterward (OR5: 1.1-1.2, p<0.001). Children between 12-16 years of age showed a continuous increase, especially boys (boys12-16: OR5: 1.3, girls12-16: OR5: 1.1, p<0.001). …"

Table1_Variation of leaf shape with tree size: a case study using Camptotheca acuminata Decne.xlsx حسب Ke He (331344)

"…However, DBH did not significantly affect the ratio W/L nor the leaf roundness index. …"

<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian... حسب Silvia Torchio (611349)

"…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. Moreover, they exhibited dysregulated Ca²⁺ fluxes due to altered transcription of Ca²⁺-related genes, including <i>CACNA1D</i>, and significantly reduced <i>SNAP25</i> levels, leading to uncoordinated oscillations and poor glucose responsiveness. …"

Figure 2 from Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer حسب Robert J. Lake (22408833)

"…<b>F,</b> Interaction between auranofin and cisplatin was analyzed by one-way ANOVA with Holm–Šídák multiple comparisons test (single pooled variance). **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001; ns, not significant. <b>G,</b> CI values, calculated using the Chou–Talalay median-effect method, are plotted against the fraction of cells affected (Fa). …"

Table 1_Effects of Veratrum nigrum expansion on soil microbial community structure in inner Mongolian mountain steppe.docx حسب Bo Pang (164741)

"…Backgrounds<p>The expansion of poisonous weeds can significantly affect soil microbial communities and their ecosystem functions. …"

Data Sheet 1_Dangua Fang induces anti-glucolipid metabolism disorder effects similar to those of direct NFIL3 inhibition.zip حسب Zhuang Han (471130)

"…The NFIL3 mRNA and protein expression levels in the serum, liver, and small intestine were significantly decreased. The relative abundance of Bacteroidota decreased, whereas that of Firmicutes increased, and changes in the gut microbiota significantly correlated with serum total cholesterol (TC), triglyceride (TG), and free fatty acid (FFA) levels. …"

Toxic effects of tetracycline on non-target lichen <i>Evernia prunastri</i> حسب Gintarė Sujetovienė (20473329)

"…At higher TC concentrations, 500 mg/L SOD activity was significantly elevated. In the case of CAT, APX and GR, TC at higher concentrations significantly decreased these enzymic activities. …"

Table 1_Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease.docx حسب Kajal Kamboj (12769602)

"…A significant increase in mRNA expression of vitamin D-responsive genes (cathelicidin, IL-10, VDR, and CYP27B1) was observed. …"

DataSheet3_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx حسب Yiyi Zuo (19945293)

"…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …"

DataSheet2_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx حسب Yiyi Zuo (19945293)

"…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …"

DataSheet1_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.pdf حسب Yiyi Zuo (19945293)

"…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …"

DataSheet1_Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor.PDF حسب Fatma S. Mohamed (19850220)

"…In relation to WT clinicopathological features, decreased levels of hsa-miR-2355-3p showed a significant positive correlation with clinical stage (r = 0.6597, p = 0.0006) and WT metastasis (r = 0.439, p = 0.021). …"

Supplementary file 1_Tacrolimus exposure during the three-month period following allogeneic stem cell transplantation predicts overall survival.docx حسب Alzbeta Zavrelova (4885270)

"…Tacrolimus volume of distribution was 127.1 L and was not affected by any of the tested covariates, whereas clearance decreased with age according to the equation CL=7.94×e−0.0085×age and was reduced by 23% in patients who underwent repeat transplantation.…"

Supplementary file 1_Single-cell transcriptomics identifies FOSL1-regulated IGFBP3+ melanoma subtype as a neuro-immunoregulatory signaling hub facilitating tumor progression.docx حسب Wenjia Ge (22687361)

"…FOSL1 knockdown significantly increased apoptosis and decreased melanoma cell motility and proliferation in vitro.…"

Supplementary Material for: Dorsal Column Spinal Cord Stimulation Attenuates Brain-Spine Connectivity through Locomotion and Visuospatial-Specific Area Activation in Progressive Fr... حسب Zemmar A. (11259339)

"…Introduction: Freezing of gait (FOG) is a clinical phenomenon with major life impairments and significant reduction in quality of life for affected patients. …"

Model inputs. حسب Natalia Serpetti (5260715)

"…The spatial/temporal model successfully simulated the overall ongoing declining dynamics of the Black Sea ecosystem as the biomasses of the majority of the functional groups had significant observed decreasing trends during the simulation period. …"

Beyond species richness: grazing and fertilization shape temperate grassland stability through distinct stabilizing effects حسب Baoshuang Hu (22147222)

"…Alterations in land use, particularly grazing and fertilization, pose significant threats to the stability of grassland ecosystems. …"

Image 1_STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit.tiff حسب Mohammad Jodeiri Farshbaf (20466956)

"…Introduction<p>Diabetes is a metabolic disorder of glucose homeostasis that is a significant risk factor for neurodegenerative diseases, such as Alzheimer’s disease, as well as mood disorders, which often precede neurodegenerative conditions. …"

raw data حسب Boya Gao (21686150)

"…<b>Results: </b>The findings reveal that higher disturbance intensity significantly alters soil nutrient levels, which in turn affects microbial diversity, abundance, community composition, and interspecies interactions. …"

Data Sheet 1_Strategies for enhancing yield and quality of forage-grain dual-purpose ratoon rice: role of first-season density and nitrogen management.docx حسب Yuyuan Ouyang (15350374)

"…Results showed that: Silage yield increased significantly with higher density and nitrogen input. …"