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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
associated decrease » associated increase (Expand Search), associated disease (Expand Search), associated diseases (Expand Search)
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5661
Image 7_Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma.jpeg
Published 2025“…Richness was significantly decreased from pre-treat to post-treat.…”
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5662
Image 6_Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma.jpeg
Published 2025“…Richness was significantly decreased from pre-treat to post-treat.…”
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5663
Table 1_Correlation of serum irisin levels with diabetic nephropathy: an exhaustive systematic appraisal and meta-analytical investigation.xls
Published 2025“…</p>Conclusions<p>This meta-analysis provides evidence for an association between serum irisin levels and DN. Lower serum irisin levels were related to more severe albuminuria and decreased eGFR in T2DM patients. …”
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5664
Table 6_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5665
Presentation 1_Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering.pptx
Published 2025“…Background<p>The advent of biologics has significantly transformed treatment strategies for neuromyelitis optica spectrum disorder (NMOSD). …”
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5666
Table 3_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5667
Table 5_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5668
Table 1_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5669
DataSheet1_Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis.PDF
Published 2024“…</p>Results<p>After treatment with HKC, EB, and their combination for 4 weeks, the urinary albumin-to-creatinine ratios decreased significantly in the db/db mice with DN. …”
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5670
Table 1_Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease.docx
Published 2025“…</p>Results<p>The proportion of RUNX2-positive cells in KBD cartilage was significantly higher than in controls. RUNX2 mRNA levels were elevated, whereas methylation levels were reduced in KBD samples. …”
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5671
Table 2_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5672
Table 4_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati...
Published 2025“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”
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5673
Supplementary Material for: Exosomal TIMP4 from myocardial cell relieves heart failure by influencing Th17/Treg Balance
Published 2025“…Results: Analysis of the GSE196656 dataset revealed significant upregulation of TIMP4 in heart failure. …”
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5674
Data Sheet 1_Changes in cortical brain activity after active break in preschoolers: MOVI-HIIT study.pdf
Published 2025“…Conversely, Beta and Gamma bands showed reductions, especially in frontal, temporal, and parietal regions, indicating decreased stress and mental effort.</p>Discussion<p>These effects persisted for up to 20 min after exercise, suggesting that brief, high-intensity exercise induces EEG changes associated with states of attentional readiness and emotional regulation, which may support learning, pending further validation.…”
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5675
Data Sheet 1_Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database.docx
Published 2025“…Objective<p>This study aims to analyze the adverse drug events (ADEs) associated with tolvaptan in the Food and Drug Administration Adverse Event Reporting System database from the fourth quarter of 2009 to the second quarter of 2024.…”
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5676
Data Sheet 1_Efficacy and safety of SGLT2 inhibitors in acute heart failure: a systematic review and meta-analysis of randomized controlled trials.docx
Published 2025“…SGLT2 inhibitors were associated with decreased all-cause mortality (RR = 0.61, 95% CI = 0.40, 0.95; P = 0.03), worsening of HF (RR = 0.59, 95%CI = 0.36, 0.97;P = 0.04), and GFR (MD: 1.05, 95% CI = 0.68, 1.43; P < 0.00001) compared with the control group. …”
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5677
Beyond species richness: grazing and fertilization shape temperate grassland stability through distinct stabilizing effects
Published 2025“…Alterations in land use, particularly grazing and fertilization, pose significant threats to the stability of grassland ecosystems. …”
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5678
Data Sheet 1_FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels.docx
Published 2025“…Mediation analysis revealed triglycerides, HDL-C, and FBG as significant mediators for the associations of rs9939609 and rs17817449 with MetS (all P < 0.001).…”
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5679
Presentation_1_Multifaceted neuroprotective approach of Trolox in Alzheimer's disease mouse model: targeting Aβ pathology, neuroinflammation, oxidative stress, and synaptic dysfunc...
Published 2024“…This research study is significant as it aims to assess the neuroprotective properties of vitamin E (VE) analog Trolox in an Aβ<sub>1 − 42</sub>-induced AD mouse model. …”
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5680
Image 2_Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach.jpeg
Published 2025“…Isolated lung trNK cells of the ALI mice exhibited reduced CD107a and NKp46 markers and cytotoxicity potentials and were correlated through significantly 2.1-fold higher levels of PD-1 and diminished VDR expressions as compared to naïve mice. …”