SMR reveals common molecular patterns. by Daniela Fusco (10027975)

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement by Juraj Velcicky (2201350)

“…Initial indole analog <b>7</b> demonstrated a robust in vivo IL-1β inhibition, but also a significant hERG inhibition. Decreasing lipophilicity led to the discovery of <b>NP3-742</b>, demonstrating a favorable overall profile including diminished hERG inhibition and in vivo efficacy in a mouse peritonitis model.…”

Degradation of virion-associated RNA following acid treatment. by Muriel Aldunate (22411177)

Age-dependent expression of <i>ANXA1</i> gene in monocytes and their subtypes. by Juliane F. Tampé (19976538)

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Changes in the physiological indexes of two oat varieties under drought stress and normal water supply treatments. by Caijin Chen (3107787)

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Workflow of the study. by Juliane F. Tampé (19976538)

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Age-related correlation of PBMCs percentages. by Juliane F. Tampé (19976538)

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WGCNA of the sample characteristics and proteins of the two oat varieties under drought stress. by Caijin Chen (3107787)

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Changes in the growth of two oat varieties under drought stress and normal water supply treatments. by Caijin Chen (3107787)

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Age-dependent changes in neuroinflammation-related gene expression in males and females. by Juliane F. Tampé (19976538)

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Volcano map of DAPs. by Caijin Chen (3107787)

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KEGG pathway enrichment bubble map of the top 20 DAPs. by Caijin Chen (3107787)

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Normalized sample plots for each treatment for data quality control. by Caijin Chen (3107787)

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FACS gating strategy for isolated PBMCs, followed by sorting and analysis of the three monocyte subtypes. by Juliane F. Tampé (19976538)

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Basic physical and chemical properties of the soils. by Caijin Chen (3107787)

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Supplementary Figs 1–7. by Juliane F. Tampé (19976538)

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Supplementary Tables 1–8. by Juliane F. Tampé (19976538)

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Different responses of two oat varieties to drought stress. by Caijin Chen (3107787)

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