Supplementary Material for: Effect of frail phenotype on cardiorenal risk and healthcare utilization in older patients with chronic kidney disease by Sun C.-Y. (10070377)

“…Every one-point frailty elevated composite renal outcome risk by 28.0 % (HR: 1.28, 95% CI:1.03–1.59) and significantly increased secondary outcomes (hospitalization [HR: 1.24, 95% CI: 1.06–1.46], unexpected ER visit [HR: 1.20, [95% CI:1.03–1.39], and mortality [HR: 1.51, 95% CI: 1.06–2.16]) but not for MACE [HR: 1.43, 95% CI: 0.99–2.08]. …”

Image 2_Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective... by Paulo Ranaivomanana (775831)

“…A significantly higher proportion of positive QFT-P tests was observed in the TBDM group compared to the TBP group (91.3% vs 64.1%) at the end of the treatment (p=0.03). …”

Image 1_Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective... by Paulo Ranaivomanana (775831)

“…A significantly higher proportion of positive QFT-P tests was observed in the TBDM group compared to the TBP group (91.3% vs 64.1%) at the end of the treatment (p=0.03). …”

Dexmedetomidine pretreatment alleviates brain injury in middle cerebral artery occlusion (MCAO) model rats by activating PI3K/AKT/NF-κB signaling pathway by Wei Gao (2085)

“…DEX pretreatment reversed the effects of MCAO as evidenced by decrease in protein expression levels of TNF-α and IL-6 associated with elevated protein expression levels of PI3K/AKT/NF-κB signaling pathway. …”

Image 2_Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors assoc... by Hervé Monka Lekuya (17285065)

“…</p>Conclusion<p>Delayed surgical intervention beyond 48 h post-injury in mild–moderate TBI patients results in a significantly increased postoperative inflammatory response, as evidenced by elevated serum levels of TNF-α and IL-6. …”

Image 3_Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors assoc... by Hervé Monka Lekuya (17285065)

“…</p>Conclusion<p>Delayed surgical intervention beyond 48 h post-injury in mild–moderate TBI patients results in a significantly increased postoperative inflammatory response, as evidenced by elevated serum levels of TNF-α and IL-6. …”

Image 1_Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild–moderate traumatic brain injury patients and factors assoc... by Hervé Monka Lekuya (17285065)

“…</p>Conclusion<p>Delayed surgical intervention beyond 48 h post-injury in mild–moderate TBI patients results in a significantly increased postoperative inflammatory response, as evidenced by elevated serum levels of TNF-α and IL-6. …”

Data Sheet 1_Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites.docx by Sui Li (8872481)

“…Moreover, combination therapy led to an increase in the proportion of probiotic bacteria in the mouse gut microbiota, resulting in elevated levels of antitumor metabolites and a decrease in metabolites that affect immune cell function.…”

Image 1_Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.tif by Lu Liu (171341)

“…Studies utilizing a murine model of subcutaneous HCC xenografts confirmed that EPE effectively inhibited tumor growth, promoted tumor cell death, and significantly elevated the levels of the NK cell activation markers IFN-γ and CD107a in the spleen and tumor tissues of HCC-bearing mice. …”

Related to Fig 1. by Mohammad Nafees Ansari (22232505)

“…(<b>O</b>, <b>P</b>) Fold change of glucosylceramides (mean ± SEM, <i>n</i> = 4) confirms no significant increase in glucosylceramides in MCF-7_UGCG^DEAD and BT-474_UGCG^DEAD cells compared to MCF-7 and BT-474 cells. …”

Mitochondrial electron transport chain disruption and oxidative stress in lipopolysaccharide-induced cardiac dysfunction in rats and mice by Agda Aline Pereira de Sousa (21369738)

“…In a more acute Langendorff-perfused rat hearts, LPS infusion (0.5 μg/mL) induced a significant elevation in left ventricular end-diastolic pressure and a decrease in left ventricular developed pressure. …”

Table3_Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.xlsx by Mohammed Dashti (4849747)

“…</p>Results<p>The analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”

Table4_Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.xlsx by Mohammed Dashti (4849747)

“…</p>Results<p>The analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”

Table 1_Overall leukocyte levels link risk factors to Von Willebrand factor and Neutrophil Extracellular Traps in stroke thrombi: a Structural Equation Modeling analysis.docx by Lin Shi (65217)

“…</p>Results<p>Heart dysfunction and blood glucose showed a significant negative indirect effect on VWF through the overall leukocyte levels (indirect effect = −0.119 and −0.118, p < 0.05). …”

Data Sheet 1_The association between the gut microbiome and antituberculosis drug-induced liver injury.docx by Shengfei Pei (20852069)

“…</p>Results<p>Following anti-TB treatment, we observed a decrease in microbial diversity and significant structural changes in the gut microbiota of TB patients (P < 0.05). …”

Table1_Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.xlsx by Mohammed Dashti (4849747)

“…</p>Results<p>The analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”

Table2_Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.xlsx by Mohammed Dashti (4849747)

“…</p>Results<p>The analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”

Crystal violet assay. by Takanori Kitagawa (20727226)

“…YCW-H demonstrated significant anti-proliferative effects on MCF7 cells, reducing cell growth by 58.7% ± 6.9 even when physically separated from the cells by a plastic wall. …”

Image 3_Chemogenetic modulation of the rat locus coeruleus alters hippocampal noradrenaline release and modulates perforant path-evoked responses.tif by Sielke Caestecker (20749481)

“…</p>Results<p>In a significant number of rats (7/15) we found an increase in hippocampal NA release, field excitatory post synaptic potential (fEPSP) slope and population spike (PS) amplitude, indicating an increase in excitatory neurotransmission and neuronal output. 4/15 rats showed a decrease in NA release without changes in fEPSP slope or PS amplitude, and 4/15 showed no change in NA release.…”

Table_2_Proteomics fingerprinting reveals importance of iron and oxidative stress in Streptomyces scabies–Solanum tuberosum interactions.docx by Lauriane Giroux (19779051)

“…The increase in the abundance of proteins related to pyochelin biosynthesis was consistent with a significant decrease in the iron content in the culture medium, as well as with induction of expression of pyochelin biosynthesis genes. …”