Image_1_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…HOMA-IR score and IR significantly increased in HFD-fed mice, with further elevation in HOMA-IR score following Glu supplementations (mainly L-Glu). …”

Image_1_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…HOMA-IR score and IR significantly increased in HFD-fed mice, with further elevation in HOMA-IR score following Glu supplementations (mainly L-Glu). …”

Image_2_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…HOMA-IR score and IR significantly increased in HFD-fed mice, with further elevation in HOMA-IR score following Glu supplementations (mainly L-Glu). …”

Image_2_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…HOMA-IR score and IR significantly increased in HFD-fed mice, with further elevation in HOMA-IR score following Glu supplementations (mainly L-Glu). …”

Image 3_Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis.tif by Sheng-Yi He (20373678)

“…</p>Results<p>Both SEI_CMAP and SEI_MUNIX exhibited significant reductions in ALS patients compared to that in controls (P_SEICMAp < 0.0001, P_SEIMUNIX < 0.0001), while SEI_EI showed an elevation (P < 0.0001). …”

Image 4_Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis.tif by Sheng-Yi He (20373678)

“…</p>Results<p>Both SEI_CMAP and SEI_MUNIX exhibited significant reductions in ALS patients compared to that in controls (P_SEICMAp < 0.0001, P_SEIMUNIX < 0.0001), while SEI_EI showed an elevation (P < 0.0001). …”

Image 2_Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis.tif by Sheng-Yi He (20373678)

“…</p>Results<p>Both SEI_CMAP and SEI_MUNIX exhibited significant reductions in ALS patients compared to that in controls (P_SEICMAp < 0.0001, P_SEIMUNIX < 0.0001), while SEI_EI showed an elevation (P < 0.0001). …”

Image 1_Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis.tif by Sheng-Yi He (20373678)

“…</p>Results<p>Both SEI_CMAP and SEI_MUNIX exhibited significant reductions in ALS patients compared to that in controls (P_SEICMAp < 0.0001, P_SEIMUNIX < 0.0001), while SEI_EI showed an elevation (P < 0.0001). …”

Data Sheet 1_Exploring the glucose-lowering and anti-inflammatory immune mechanism of artemether by AMPK/mTOR pathway and microbiome based on multi-omics.docx by Tao Jiang (28401)

“…</p>Conclusion<p>Taken together, ATM may modulate the composition of gut microbiota, increasing the abundance of Lactobacillus, which in turn elevates the levels of SCFAs. The elevation of SCFAs, especially propionic acid, may activate the AMPK/mTOR pathway, leading to a decrease in the levels of TNF-α, IL-1β, IL-6, NF-κB, and IL-17A, while increasing the levels of IL-10, thereby alleviating the inflammatory state and improving glucolipid metabolic disorder in T2DM. …”

Table1_Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site.docx by Olivia C. Ihedioha (19925886)

“…Notably, the level of LRP6 expressing neutrophils was elevated in infected BALB/c mice. Relative to infected BALB/c mice, a significant reduction in parasite load was observed in both LRP6^NKO and LRP6^NKO DKK1^PKO infected mice. …”

DataSheet1_Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study.zi... by Yanjun Liang (4394089)

“…However, genetically predicted 25(OH)D did not have a significant impact on kidney function.</p>Conclusions<p>Elevated serum Ca or P levels could both impair kidney function, whereas 25(OH)D has no impact on renal function.…”

<b>IER3IP1 mutations cause neonatal diabetes due to impaired proinsulin trafficking</b> by Hossam Montaser (10017443)

“…While these mutant stem cell lines differentiated normally into definitive endoderm and pancreatic progenitors, we observed that IER3IP1-KO stem cell derived-islets (SC-islets) presented a significant decrease in beta cell numbers and elevated ER stress. …”

Image 4_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Image 2_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Image 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Image 5_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Table 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.docx by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Image 3_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Supplementary Material for: Safety profile of intravitreal Dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies. by figshare admin karger (2628495)

“…The incidence of IOP-related AEs varied significantly from study to study, from 2% to almost 60%. …”

Data Sheet 1_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”