Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... حسب Huijing Ren (19986303)

"…Interference with this pathway significantly influenced the therapeutic effects of CPGB in the 3D-NVU model. …"

Image 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf حسب Kai Sun (140584)

"…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …"

Table 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx حسب Kai Sun (140584)

"…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …"

Table 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx حسب Kai Sun (140584)

"…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …"

Image 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf حسب Kai Sun (140584)

"…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …"

Data Sheet 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx حسب Kai Sun (140584)

"…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …"

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. حسب Vanessa Kay Miller (19775496)

"…The Or42a OSN innervation volume with glial <i>5-HT</i>_<i>2A</i><i>R</i> OE is very significantly decreased in comparison to the control EB condition (<i>p</i> = 4.64 × 10⁻¹⁰). …"

Image 1_Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome.jpeg حسب Mailén Rojo (10802556)

"…However, mtDNA oxidation levels did not differ significantly among these groups. Additionally, the decline in mtDNA content and the increase in oxidation levels between controls and patients with PCOS lost significance when these relationships were adjusted for the HOMA index.…"

Supplementary file 1_Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study.docx حسب Ting Zhang (102583)

"…Meanwhile, C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), and Creatine Kinase (CK) levels decreased significantly. Also, the incidence of complications and acute exacerbation was lower in the combined group (P < 0.05). …"

Table 1_Immunomodulatory peptide–drug conjugate MEL-dKLA suppresses progression of prostate cancer by eliminating M2-like tumor-associated macrophages.docx حسب Ik-Hwan Han (8605281)

"…In vivo, MEL-dKLA treatment significantly reduced tumor growth, decreased the number of CD163⁺ M2 macrophages, and increased CD8⁺ T cell infiltration in tumor tissues. …"

Supplementary Material for: Splice variant of retinal G-protein-coupled receptor deletion (RGR-d)-mediated dysregulation of autophagy increases the susceptibility to age-related ma... حسب Guo Y. (2986464)

"…Beclin-1 and LC3II/I expression levels were significantly decreased and that of P62 was elevated in RGR-d cells after PA stimulation. …"

Data Sheet 1_Impact of endurance training on mitochondrial H2O2 production and NRF2 levels in different rat organs.pdf حسب Lukasz Galganski (22442002)

"…NRF2 protein levels were significantly elevated in all examined tissues, accompanied by an increase in glutathione reductase levels.…"

Table 2_Immunomodulatory peptide–drug conjugate MEL-dKLA suppresses progression of prostate cancer by eliminating M2-like tumor-associated macrophages.docx حسب Ik-Hwan Han (8605281)

"…In vivo, MEL-dKLA treatment significantly reduced tumor growth, decreased the number of CD163⁺ M2 macrophages, and increased CD8⁺ T cell infiltration in tumor tissues. …"

Single-cell RNA-seq dataset of innate lymphoid cells حسب Sijie Chen (12510043)

"…Our research, along with others’, indicates a high proportion of LTi cells in the fetal ILC pool, which significantly decreases after birth. Conversely, the proportion of non-LTi ILCs increases postnatally, corresponding to the need for LTi cells to mediate lymphoid tissue formation during fetal stages and other ILC subsets to combat diverse pathogen infections postnatally. …"

Data Sheet 2_Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.doc حسب Haoxiang Sun (6396902)

"…Furthermore, Op D inhibited ER stress, decreased GRP78 expression, reduced NGN3 levels, elevated PDX1, NKX6.1, and MAFA expression, and decreased oxidative stress-related products (ROS, MDA) while increasing SOD and GSH levels.…"

DataSheet1_Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis.pdf حسب Chunxin Jiang (5212205)

"…By Western blotting, we detected decreased intracellular expression of Sirt3 and elevated phosphorylation of JNK after phenylephrine stimulation, but this was reversed in cells pretreated with Genz-123346. …"

Data Sheet 1_Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.doc حسب Haoxiang Sun (6396902)

"…Furthermore, Op D inhibited ER stress, decreased GRP78 expression, reduced NGN3 levels, elevated PDX1, NKX6.1, and MAFA expression, and decreased oxidative stress-related products (ROS, MDA) while increasing SOD and GSH levels.…"

Supplementary Material for: Impairment of Renal Function in Hermansky-Pudlak Syndrome حسب Yokoyama T. (4606381)

"…Calculated eGFR of adult patients with different HPS types differed significantly, and calculated eGFR of pediatric and adult patients with BLOC-3 disorders was significantly lower than that of patients with BLOC-2 disorders. …"

Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders حسب Santosh Kumar Rai (22382996)

"…Further evaluation of MKP10241 in the STAM mouse model of MASH/MASLD showed significant MASH resolution. MKP10241 was evaluated in preclinical toxicity and genotoxicity studies in rats and dogs and found safe. …"

Data Sheet 1_Deciphering ERR family genes as prognostic and immunological biomarkers through pan-cancer analysis with validation in gallbladder cancer.pdf حسب Wanwan Gong (21187838)

"…All three ERRs demonstrate significant prognostic value across different cancers. …"