Image 5_Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways.tiff by Ayaka Goto (20858771)

“…</p>Results<p>Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. …”

Evolutionary tree analysis of ZmSTOMAGEN. by Juan-Juan Xu (18590868)

“…These included brassinosteroid metabolite imbalance (increased typhasterol, decreased castasterone) and differential gibberellin regulation (elevated GA4, reduced GA1). …”

Table 1_Sex-specific association between triglyceride-glucose index and all-cause mortality in patients with osteoporotic fractures: a retrospective cohort study.docx by Shao-han Guo (19690687)

“…TyG-I indicated a statistically significant relation with sex (P for interaction = 0.01).…”

Supplementary file 1_Sex-specific association between triglyceride-glucose index and all-cause mortality in patients with osteoporotic fractures: a retrospective cohort study.xlsx by Shao-han Guo (19690687)

“…TyG-I indicated a statistically significant relation with sex (P for interaction = 0.01).…”

Data Sheet 1_Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort.docx by Chang Liu (35901)

“…Over an average follow-up period of 110 days, significant decreases in CO and CI were observed in the paired participants. …”

Raw data for all figures. by Juan-Juan Xu (18590868)

“…These included brassinosteroid metabolite imbalance (increased typhasterol, decreased castasterone) and differential gibberellin regulation (elevated GA4, reduced GA1). …”

Table 1_Coffee consumption as a double-edged sword for serum lipid profile: findings from NHANES 2005–2020.docx by Chaoyue Mo (21684056)

“…Although these changes were statistically significant, their clinical relevance may vary depending on individual cardiovascular risk profiles.…”

Supplementary file 1_Association between changes in corrected anion gap and mortality among critically ill patients during ICU stay: a multicenter observational study.doc by Yanli Hou (6561536)

“…When analyzed categorically, the ΔcAG still exhibited a significant risk gradient across quartiles.</p>Conclusion<p>Further elevated cAG after ICU admission demonstrates a robust association with an increased mortality risk in critically ill patients. …”

Supplementary file 1_Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stroma... by Huijie Lai (22696685)

“…Conversely, PTEN expression was found to be decreased. Additionally, autophagy-related protein levels were diminished while anti-apoptotic protein expression was markedly elevated (P < 0.01). …”

Data Sheet 1_Modified life’s essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.docx by Juanjuan Fang (413481)

“…After full adjustment for covariates, mLE8 exhibited a significant mediating role in the associations of both DI-GM (14.46% mediated effect, p < 0.001) and DI-GM beneficial (12.99% mediated effect, p < 0.001) with sleep disorders. …”

Supplementary file 2_Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stroma... by Huijie Lai (22696685)

“…Conversely, PTEN expression was found to be decreased. Additionally, autophagy-related protein levels were diminished while anti-apoptotic protein expression was markedly elevated (P < 0.01). …”

Boxplots showing the differences in miR-21-5p and miR-16-5p levels across increasing AKI severity based on Kidney Disease: Improving Global Outcomes (KDIGO) grades. by Tamar J. van der Aart (22184206)

“…<p>Elevated miR-21-5p levels and decreased miR-16-5p levels correspond to greater AKI severity. …”

Supplementary file 1_Potential interactions between traditional Chinese medicine and osimertinib: a Case Report.docx by Min Zhang (111999)

“…The first osimertinib trough concentration (C_trough) was 82.1 ng/mL, significantly lower than the FDA-reported 166 ng/mL, with concurrent elevation of the tumor marker carcinoembryonic antigen (CEA). …”

Supplementary file 2_Quantile regression application to identify key determinants of malnutrition in five West African countries of Gabon, Gambia, Liberia, Mauritania, and Nigeria.... by Reshav Beni (21422981)

“…Background<p>Malnutrition remains one of the most pressing health challenges, particularly in developing nations across Africa, placing a significant burden on both public health agencies and the affected countries. …”

Supplementary file 1_Quantile regression application to identify key determinants of malnutrition in five West African countries of Gabon, Gambia, Liberia, Mauritania, and Nigeria.... by Reshav Beni (21422981)

“…Background<p>Malnutrition remains one of the most pressing health challenges, particularly in developing nations across Africa, placing a significant burden on both public health agencies and the affected countries. …”

Table 1_The knowledge paradox: an inverted U-shaped association between HIV knowledge and stigma among older men in Sichuan Province, Southwest China.docx by Zhihua Ye (3133311)

“…Background<p>Older men (≥50 years) in China face elevated HIV infection risks, yet HIV stigma remains a significant barrier to prevention. …”

Data Sheet 1_Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.docx by Omkar B. Ijare (22274167)

“…The CE-to-cholesterol ratio of 0.44 in the recurrent tumor suggests significant cholesterol esterification during malignant progression.…”

Data Sheet 2_Effect of thyme-ivy syrup on antiviral immune response in patients with mild COVID-19: a prospective, open-label, randomized pilot study.docx by Stephanie Dauth (13274397)

“…Significant between-group differences were observed for changes in some parameters at day 4 (e.g., IL-10) and day 14. …”

Data Sheet 1_Effect of thyme-ivy syrup on antiviral immune response in patients with mild COVID-19: a prospective, open-label, randomized pilot study.docx by Stephanie Dauth (13274397)

“…Significant between-group differences were observed for changes in some parameters at day 4 (e.g., IL-10) and day 14. …”

Data Sheet 1_Past and future trends in swiss snow cover: multi-decades analysis using the snow observation from space algorithm.docx by Charlotte Poussin (20718146)

“…The pixel-wise analysis reveals significant negative trends in the monthly NDSI across all seasons, with the most pronounced decreases at low to mid-elevations, particularly in winter and spring (e.g., a 50% reduction in NDSI for pixels showing positive significative trends in winter below 1,000 m, and a 43% reduction in spring between 1,000 and 2,000 m). …”