Image_3_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.JPEG by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Image_2_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.JPEG by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Image_1_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.JPEG by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Image_4_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.JPEG by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Table_1_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.XLSX by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Presentation_1_Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling.pdf by Bin Zhang (64682)

“…In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells. …”

Data Sheet 1_Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation.zip by Raheem F. H. Al Aameri (14951800)

“…C57BL/6J mice treated with two cycles of cisplatin (3.5 mg/kg) showed a significant elevation in ABR thresholds, along with loss of outer hair cells and inner hair cells synapse. …”

Table_2_Microclimate shapes the phylosymbiosis of rodent gut microbiota in Jordan’s Great Rift Valley.XLSX by Enas Al-khlifeh (17286364)

“…We found that bioclimatic zone had a significant effect on the gut microbiota composition while host phylogeny did not. …”

Table_1_Microclimate shapes the phylosymbiosis of rodent gut microbiota in Jordan’s Great Rift Valley.XLSX by Enas Al-khlifeh (17286364)

“…We found that bioclimatic zone had a significant effect on the gut microbiota composition while host phylogeny did not. …”

Spatiotemporal variations of fractional vegetation cover and its response to topography on the Loess Plateau of China from 1995 to 2024 by Fan Fu (1361535)

“…Under categorized conditions, FVC initially decreases and then increases with elevation and topographic position index, while it exhibits a fluctuating upward trend with increasing slope, terrain roughness, and topographic complexity index. …”

Mitigation of Senescence Burden in Doxorubicin-Induced Senescent Endothelial Cells by MitoQ Treatment Through Diminishing Mitochondrial ROS and DNA Damage. by Hossein Abdeahad (22177792)

“…Co-treatment with MitoQ significantly reduced mtROS, preserved mitochondrial mass, and mitigated DNA damage and senescence phenotypes. …”

Data from: Population structure varies among four western North American bumble bee species by Elizabeth Sakulich (22077908)

“…However, as climate change increases temperatures, montane populations are restricted to higher elevations and their ability to disperse and maintain genetic diversity decreases as suitable habitat connecting populations decreases. …”

Data Sheet 1_Synergistic effect of regorafenib with aminoglycosides in ferroptosis-mediated liver injury.docx by Maha Raja Dahar (21716714)

“…The real-time quantitative polymerase chain reaction (RT-qPCR) and immunoblotting assay results show downregulation of GPX4 and SLC7A11 expressions, along with elevation of ALOX-15 (3- to 6-fold change).</p>Conclusion<p>Thus, combination therapy of regorafenib with amikacin and gentamycin causes significant elevation of iron and lipid peroxidation levels and alteration in protein expressions, which mediates ferroptotic cell death and leads to liver injury.…”

Shift in the Microbial Community Composition in Lake Wetland Sediments in the Source Region of the Yellow River Linked to Environmental Factors by Hexing Qi (20730615)

“…The results highlighted that rather than the fungal community, the bacterial community in sediments exhibited more significant spatial variation in lake wetlands driving by the influence of elevation and physicochemical variables.…”

Data from: Decade-long bird trends in China: Stable species richness but increasing biotic homogenization by Jiekun He (20964269)

“…In contrast, functional richness increased significantly (Zr = 0.122, 95% CI = [0.016; 0.227]). …”

Data Sheet 1_Potential geographical distribution of Cordyceps cicadae and its two hosts in China under climate change.docx by Junyi Chen (776323)

“…C. cicadae thrived on steep slopes. and some of which also significantly affect the distribution of its two hosts. …”

Data Sheet 1_Evaluating the efficacy of different doses of tocilizumab in treating critically ill COVID–19 patients: a single–center retrospective cohort study.docx by Jie Gao (10266)

“…The number of TCZ doses had no significant impact on length of hospital stay, duration of mechanical ventilation, or the incidence of complications such as respiratory failure requiring mechanical ventilation, heart failure, secondary infections, thrombotic/embolic events, transaminase elevation, neutropenia, GI perforation/Haemorrhage, or acute kidney injury.…”

Image 1_Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers.tiff by Gaetano Zizzo (15853004)

“…Blood culture-negative sepses showed shorter stays and higher mortality (acute kidney injury and fast deterioration) compared to culture-positive ones; polymicrobial sepses showed higher ICU transfer rates (acute respiratory distress); while multidrug-resistant (MDR⁺) and/or polymicrobial sepses showed longer stays and higher mortality (complicated course) compared to drug-sensitive or monomicrobial ones. C-reactive protein elevation predicted rapidly evolving culture-negative sepsis, whereas lower leukocyte counts predicted prolonged hospitalization; higher fractions of inspired oxygen predicted polymicrobial sepsis, while lactate elevation predicted ICU transfer; ferritin elevation and increased leukocyte counts predicted MDR⁺ sepsis, while further ferritin elevation and decreased platelet counts predicted death. …”

Image 2_Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers.tiff by Gaetano Zizzo (15853004)

“…Blood culture-negative sepses showed shorter stays and higher mortality (acute kidney injury and fast deterioration) compared to culture-positive ones; polymicrobial sepses showed higher ICU transfer rates (acute respiratory distress); while multidrug-resistant (MDR⁺) and/or polymicrobial sepses showed longer stays and higher mortality (complicated course) compared to drug-sensitive or monomicrobial ones. C-reactive protein elevation predicted rapidly evolving culture-negative sepsis, whereas lower leukocyte counts predicted prolonged hospitalization; higher fractions of inspired oxygen predicted polymicrobial sepsis, while lactate elevation predicted ICU transfer; ferritin elevation and increased leukocyte counts predicted MDR⁺ sepsis, while further ferritin elevation and decreased platelet counts predicted death. …”

Data Sheet 14_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf by Didar Murad (12220805)

“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”