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significantly enhanced » significantly influenced (Expand Search), significantly reduced (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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20021
Table 2_Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling.xlsx
Published 2025“…Furthermore, a medium dosage of GDL treatment significantly rebalance microbiota composition and function and modulated lipid and lipid-like molecule levels.…”
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20022
Data Sheet 1_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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20023
data.zip
Published 2025“…Compared with the control group, the thickness of retina in the experimental group was significantly reduced (t=5, P=0.0075), the number of retinal pigment epithelium was statistically decreased (t=4.243, P=0.0132), and the pyrolytic related proteins NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 were strongly red positive in retinal pigment epithelium (P<0.05). …”
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20024
Data_Sheet_1_MakC and MakD are two proteins associated with a tripartite toxin of Vibrio cholerae.pdf
Published 2024“…Through deletion mutant analysis, we found that individual deletions of makC or makD do not significantly affect MakA expression or secretion. However, the deletion of both makC and makD impairs the expression of MakB, which is directly downstream, and decreases the expression of MakE, which is separated from makCD by two genes. …”
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20025
Table 1_Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machine learning.x...
Published 2025“…Recovery analysis showed significantly reduced adaptive immune cells at 1 month, with partial recovery by 3 and 6 months. …”
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20026
Data Sheet 8_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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20027
Data Sheet 1_Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop.pdf
Published 2025“…Furthermore, 100 nM CTS ouabain, a specific Na,K-ATPase ligand, significantly decreased Aβ′s impact on APP and Src kinase activation. …”
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20028
Soil viral and microbial interactions facilitate microbial necromass carbon accumulation in the semiarid typical steppe under altered precipitation_Research data
Published 2025“…The results showed that decreased precipitation significantly reduced microbial necromass carbon (BNC, MNC, and BNC/MNC) and their relative contributions to SOC (BNC/SOC and MNC/SOC), whereas increased precipitation had relatively weaker effects. …”
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20029
Spatiotemporal dynamics of sea ice volume and their potential drivers in Liaodong Bay, China, using Sentinel-3 data over five ice seasons
Published 2025“…<p>Global sea ice extent has notably decreased in recent decades due to climate warming. …”
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20030
Image 1_REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway.jpg
Published 2025“…</p>Results<p>RNA sequencing revealed REDD1 was significantly upregulated in BDL-induced fibrotic liver tissue. …”
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20031
DataSheet10_Refining dual RNA-seq mapping: sequential and combined approaches in host-parasitic plant dynamics.csv
Published 2024“…The evolutionary distance between parasitic and host plants did not significantly impact the accuracy of read assignment to their respective genomes since enough polymorphisms were present to ensure reliable differentiation. …”
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20032
Image 6_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif
Published 2025“…</p>Results<p>Behavioral tests revealed that low-frequency EA significantly alleviated depressive-like behaviors and cognitive impairment. …”
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20033
Table_1_Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation.docx
Published 2025“…Tick protease inhibitors have significantly decreased psoriasis symptoms and disease manifestations but had differential effects on inflammatory responses and immune cell populations, suggesting different modes of action of these inhibitors on psoriasis-like inflammation. …”
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20034
Alternative therapeutic strategy for existing aortic aneurysms using mesenchymal stem cell–derived exosomes
Published 2025“…In the MSC-ex group, the expression of IL-1β, TNF-α and MCP-1 decreased, and expression of IGF-1 and TIMP-2 increased. …”
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20035
Image 1_The impact of tumor burden score on prognosis in patients after radical resection of hepatocellular carcinoma: a single-center retrospective study.tif
Published 2024“…</p>Conclusion<p>In patients undergoing radical resection for HCC, higher TBS was significantly related to shorter OS and RFS.</p>…”
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20036
Data Sheet 1_Diethyl butylmalonate attenuates cognitive deficits and depression in 5×FAD mice.docx
Published 2024“…In addition, DBM decreased the accumulation of microglia and downregulated neuroinflammation in the hippocampus and amygdala of 5×FAD mice.…”
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20037
Image 4_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif
Published 2025“…</p>Results<p>Behavioral tests revealed that low-frequency EA significantly alleviated depressive-like behaviors and cognitive impairment. …”
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20038
Image 1_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.tif
Published 2024“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”
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20039
Data Sheet 15_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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20040
Image 5_Photon budgets and the relative effects of CDOM and pigment absorptions on primary production along a coastal salinity gradient.jpeg
Published 2025“…The absorption by CDOM and detritus decreased with increasing salinity, while phytoplankton absorption followed a seasonal succession. …”