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20641
Utilization of lactate trajectory models for predicting acute kidney injury and mortality in patients with hyperlactatemia: insights across three independent cohorts
Published 2025“…When compared with the Traj-3, Traj-2 was only significantly associated with the decreased risk of hospital mortality (OR 0.17, 95% CI 0.14–0.20, <i>p</i> < 0.001), but no with the likelihood of AKI development (OR 0.90, 95% CI 0.77–1.05, <i>p</i> = 0.172). …”
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20642
Image 2_Natural killer cell as a potential predictive biomarker for early immune checkpoint inhibitor-associated cardiovascular adverse events: a retrospective cohort study.tif
Published 2025“…</p>Results<p>ScRNA-seq data revealed decreased CD8+ T and B cell proportions in the CVAEs group, while NK cell proportions increased. …”
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20643
Table 7_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.xlsx
Published 2025“…</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”
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20644
Image4_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”
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20645
IEE 33-bus system RDG units at optimal locations.
Published 2025“…<div><p>Recent research has concentrated on emphasizing the significance of incorporating renewable distributed generations (RDGs), like photovoltaic (PV) and wind turbines (WTs), into the distribution system to address issues related to distributed generation (DG) allocation. …”
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20646
SLD of 118-Bus RDS [
Published 2025“…<div><p>Recent research has concentrated on emphasizing the significance of incorporating renewable distributed generations (RDGs), like photovoltaic (PV) and wind turbines (WTs), into the distribution system to address issues related to distributed generation (DG) allocation. …”
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20647
Image 2_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif
Published 2024“…Pharmacological activation of local PVT A<sub>2A</sub>R with its agonist CGS21680 induced significantly decreased 50% paw withdrawal threshold (50%PWTs) and paw withdrawal latency (PWLs), as measured by the Von Frey test and Hargreaves test in adult mice. …”
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20648
Data Sheet 5_Beyond salt tolerance: SOS1-13’s pivotal role in regulating the immune response to Fusarium oxysporum in Solanum phureja.docx
Published 2025“…Conversely, silencing the ortholog gene NbSOS1-13 in Nicotiana benthamiana showed more accumulation of ROS, serious cell necrosis, reduced activities of SOD and CAT, significantly increased MDA level, obvious leaf wilting, decreased tolerance to infection, and reduced leaf stomatal closure rate and accelerated stomatal area. …”
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20649
Image 2_Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration.jpeg
Published 2025“…Combination treatment with Selinexor and DNR significantly increased apoptosis and DNA damage in vitro and reduced leukemia burden in zebrafish xenografts.…”
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20650
Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts
Published 2024“…In vivo studies showed that overall tumor metastasis decreased in 4T1 xenografts mice treated with MSN-PEG/TA 25 with a notable reduction in lung tumor metastasis. …”
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20651
Table 2_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.xlsx
Published 2025“…</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”
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20652
Table 1_Association between telomere length and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.docx
Published 2024“…</p>Results<p>Genetically determined longer telomere length was significantly associated with decreased risk of iNPH (OR = 0.44, 95% CI 0.24–0.80; p = 0.008). …”
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20653
Data Sheet 1_Oral immunotherapy for cow’s milk allergy in children: a systematic review and meta-analysis.docx
Published 2025“…The meta-analysis indicated that oral immunotherapy significantly facilitated desensitization in patients with cow’s milk allergy in children (relative risk [RR] 2.51, 95% CI: 1.54–4.09, I²=84.4%). …”
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20654
Image1_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”
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20655
Supplementary file 1_The effect of development on cortical auditory evoked potentials in normal hearing listeners and cochlear implant users.docx
Published 2025“…</p>Results<p>Both onset and ACC responses were present across groups, with P1 latency decreasing significantly with age in NH and CI listeners. …”
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20656
Image 3_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff
Published 2025“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”
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20657
Table 1_Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mix...
Published 2025“…The GAMM model revealed that PLT counts for patients who died were significantly lower and had a downward trend, while the survival group’s counts trended upward; the difference between the two groups generally exhibited an upward trend after admission, with a calculated average daily increase of 12.919 × 10<sup>9</sup>/L.…”
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20658
Supplementary file 1_Dynamic changes in peripheral inflammation as a risk factor for perioperative sleep disturbances in elderly patients undergoing laparoscopic hepatobiliary surg...
Published 2025“…Findings indicated that elevated NLR and SII levels before and after surgery, alongside decreased plasma IL-10 levels post-surgery, are associated with a higher incidence of PSD. …”
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20659
Table 4_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.xlsx
Published 2025“…</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”
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20660
Table 1_Factors influencing net ecosystem carbon change in cold-temperate coniferous forests of the Da Xing’an Mountains: analysis across developmental stages based on stand, struc...
Published 2025“…Stand age, shaped by population dynamics, disturbance regimes, and management practices, significantly influences the global carbon cycle. Although forest development is known to correlate with productivity shifts, how production varies across specific stand developmental stages and the relative contributions of driving factors remain poorly understood.…”