Image 4_Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinem... by Shida Pan (12696593)

“…Multifactorial analysis showed that MELD score >18 and increased total bilirubin (TBIL) levels within one week were significant risk factors for OS. Patients with a decrease in TBIL levels within one week had significantly prolonged median OS (not reached vs 3.3months, P =0.013) and median PFS (7.03 months vs 2.77 months, P =0.010).…”

Image 2_Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinem... by Shida Pan (12696593)

“…Multifactorial analysis showed that MELD score >18 and increased total bilirubin (TBIL) levels within one week were significant risk factors for OS. Patients with a decrease in TBIL levels within one week had significantly prolonged median OS (not reached vs 3.3months, P =0.013) and median PFS (7.03 months vs 2.77 months, P =0.010).…”

Table 1_Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinem... by Shida Pan (12696593)

“…Multifactorial analysis showed that MELD score >18 and increased total bilirubin (TBIL) levels within one week were significant risk factors for OS. Patients with a decrease in TBIL levels within one week had significantly prolonged median OS (not reached vs 3.3months, P =0.013) and median PFS (7.03 months vs 2.77 months, P =0.010).…”

Image 3_Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinem... by Shida Pan (12696593)

“…Multifactorial analysis showed that MELD score >18 and increased total bilirubin (TBIL) levels within one week were significant risk factors for OS. Patients with a decrease in TBIL levels within one week had significantly prolonged median OS (not reached vs 3.3months, P =0.013) and median PFS (7.03 months vs 2.77 months, P =0.010).…”

Image 1_Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinem... by Shida Pan (12696593)

“…Multifactorial analysis showed that MELD score >18 and increased total bilirubin (TBIL) levels within one week were significant risk factors for OS. Patients with a decrease in TBIL levels within one week had significantly prolonged median OS (not reached vs 3.3months, P =0.013) and median PFS (7.03 months vs 2.77 months, P =0.010).…”

Predicting Dinitrogen Activation and Coupling with Carbon Dioxide and Other Small Molecules by Methyleneborane: A Combined DFT and Machine Learning Study by Feiying You (22119041)

“…Besides, N₂ coupling with other small molecules including formaldehyde, sulfur dioxide, acetonitrile, and <i>N</i>-ethylidenemethylamine was also examined in both thermodynamics and kinetics. …”

Image1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.tif by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Heterotrophic cell growth and dry cell yield of <i>Rhodovulum sulfidophilum</i> in artificial seawater (ASW) based growth medium of different salinities, wherein 100% corresponds t... by Shamitha Rao Morey-Yagi (19779981)

“…Asterisks indicate significant differences between 100% and decreasing concentrations of ASW tested using one-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Figs 1b</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">1c</a>) or two-way ANOVA (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0321821#pone.0321821.g001" target="_blank">Fig 1a</a>), and the Dunnett’s multiple comparison test (GraphPad Prism 9); * p < 0.05, ** p < 0.01, and *** p < 0.001.…”

Supplementary file 1_The action of ginsenoside Rg1 in patients with carotid atherosclerosis: a controlled clinical trial.docx by Xu Fang (450501)

“…Fibroblast growth factor 21 levels differed significantly among the groups (P < 0.05), whereas Lumican and Fibulin-1 levels did not (P > 0.05). …”

Step length asymmetry and step width during split-belt adaptation. by Samantha Jeffcoat (22783930)

Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy by Fang Ye (112854)

“…Furthermore, compared to free PAP-1 or PAP-1 combined with MDR inhibitors, PAP-1-loaded micelles significantly enhanced cytotoxicity and apoptosis induction in Jurkat and B16F10 cells, through mechanisms involving decreased mitochondrial membrane potential and elevated caspase-3 activity. …”

Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease by Yaru Jiang (17458815)

“…This study investigated the key genes involved in renal tubular acid-base regulation (<i>SLC4A1</i>, <i>ATP6V1B1</i> and <i>ATP6V0A4</i>) through whole exome sequencing (WES) in a clinical cohort. …”

Data Sheet 1_Saccharomyces boulardii (CNCM I-745) improves intestinal damage in sepsis by remodeling intestinal flora structure.zip by Hui-Ying Liu (10193468)

“…</p>Results<p>Sepsis led to an increase in the expression of IL-6, TNF-α, and a decrease in the expression of occludin. After treatment with S. boulardii (CNCM I-745), the inflammatory damage with sepsis was reduced, and the expression level of occludin was significantly increased. …”

Table 1_HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation.xlsx by Xu-Zhe Yu (21509801)

“…Further, only HIF1A was upregulated in the advanced stage of PTC and significantly correlated with the dedifferentiation (all P < 0.05). …”

Image 1_HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation.tif by Xu-Zhe Yu (21509801)

“…Further, only HIF1A was upregulated in the advanced stage of PTC and significantly correlated with the dedifferentiation (all P < 0.05). …”

Image1_DNA methylation-mediated FGFR1 silencing enhances NF-κB signaling: implications for asthma pathogenesis.TIF by Minglu Meng (19725085)

“…Overexpression of FGFR1 in BEAS-2B cells significantly enhanced cell proliferation and stimulated NF-ĸB transcriptional activity in HERK-293T cells. …”

miR-155 directly targets the 3′UTR of TRAF3 and STAT1. by Xinyue Zhang (271120)

“…CEFs were infected with ALV-J at an MOI of 1 for the indicated times. The levels of TRAF3 and STAT1 protein were detected by Western blotting. **, P < 0.01. ns, P > 0.05, no significant difference.…”

Effect of urea and K₂SO₄ on enzyme activity and biochemical changes of date fruit (<i>Phoenix dactilyfera</i> cv. ‘Zahedi’) during ripening by Narjes Fahadi Hoveyze (22376779)

“…<p>This study evaluated the effects of urea and potassium sulfate (K₂SO₄) at three concentrations (0, 0.5, and 1%) on the chemical and organoleptic properties of date fruit (<i>Phoenix dactylifera</i> L. cv. …”

CDCP1 regulates CDA and hENT1 expression through c-Src/PKCδ signaling pathway. by Kun-Lin Hsieh (11401919)

“…T24-CD cells exhibited increased CDA and decreased hENT1 expression, whereas T24-CDKO cells showed the opposite trend. …”