Baseline characteristics of sample by trial arm. by Stanley Carries (21172287)

“…There was a 1.32 unit (<i>p</i> = 0.085) decrease in depressive symptoms and a reduction in caregiver burden (β = -1.28, <i>p</i> = 0.020) in the intervention arm. …”

CweL trial design. by Stanley Carries (21172287)

“…There was a 1.32 unit (<i>p</i> = 0.085) decrease in depressive symptoms and a reduction in caregiver burden (β = -1.28, <i>p</i> = 0.020) in the intervention arm. …”

Participant Flow. by Stanley Carries (21172287)

“…There was a 1.32 unit (<i>p</i> = 0.085) decrease in depressive symptoms and a reduction in caregiver burden (β = -1.28, <i>p</i> = 0.020) in the intervention arm. …”

Economic cost composition by arm and outcomes. by Stanley Carries (21172287)

“…There was a 1.32 unit (<i>p</i> = 0.085) decrease in depressive symptoms and a reduction in caregiver burden (β = -1.28, <i>p</i> = 0.020) in the intervention arm. …”

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation by Huang-Ju Tu (630766)

“…Although the development of DYRK1A inhibitors has significantly advanced in recent years, the selectivity of these drugs remains a critical challenge, potentially impeding further progress. …”

DataSheet1_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…</p>Conclusion<p>Our study’s collective findings suggest a significant association of the low risk of fracture with the use of SGLT2i with other GLMs combination, SGLT2i alone, GLP-1RA, and DPP-4i, respectively. …”

DataSheet2_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…</p>Conclusion<p>Our study’s collective findings suggest a significant association of the low risk of fracture with the use of SGLT2i with other GLMs combination, SGLT2i alone, GLP-1RA, and DPP-4i, respectively. …”

DataSheet3_Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients wit... by Mohamed E. A. Mostafa (19834779)

“…</p>Conclusion<p>Our study’s collective findings suggest a significant association of the low risk of fracture with the use of SGLT2i with other GLMs combination, SGLT2i alone, GLP-1RA, and DPP-4i, respectively. …”

Image 1_The contribution of BTK signaling in myeloid cells to neuroinflammation.jpeg by Claudia Bassani (7235849)

“…Therapeutic intervention with evobrutinib ameliorated EAE severity and was associated with a significant modest decrease in the frequency of CNS-infiltrating proinflammatory macrophages. …”

Supplementary file 3_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Supplementary file 4_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Supplementary file 2_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx by Jinghuai Ni (21023477)

“…In addition, SC treatment markedly increased Runx2, Osx, Alp, and Cx3cr1 while decreasing adipogenic genes like PPARγ and C/EBPα in the bone tissue of OVX mice and BMMSCs. …”

Supplementary file 1_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx by Jinghuai Ni (21023477)

“…In addition, SC treatment markedly increased Runx2, Osx, Alp, and Cx3cr1 while decreasing adipogenic genes like PPARγ and C/EBPα in the bone tissue of OVX mice and BMMSCs. …”

Supplementary file 6_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Supplementary file 2_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Supplementary file 5_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Data Sheet 1_Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis.pdf by Takuya Murao (114383)

“…In a lethal sepsis model induced by cecal ligation and puncture (CLP), DAMP levels were significantly elevated, while OP18 treatment markedly reduced the serum DAMP levels. …”

Table 1_Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF.docx by Shaobo Ge (20505809)

“…The Kaplan–Meier survival curve showed that the 1-year cumulative survival rate of IPF patients with a BAR ≥0.12 was significantly decreased compared with the patients with a BAR <0.12. …”

Image 1_Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.tiff by Agata Tarczykowska (20620430)

“…Iron uptake (ferritin L) from ferrous fumarate (0.5 mM, 24 h) in DMT1 silenced cells was significantly decreased (60% ± 11%) in comparison to iron controls while a 1-h dose of ferrous fumarate (0.5 mM) significantly decreased ferritin L formation in the presence of the clathrin inhibitor chlorpromazine (61% ± 10%, in post-confluent cells and 37% ± 9% in non-confluent cells). …”

Table 1_Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.docx by Agata Tarczykowska (20620430)

“…Iron uptake (ferritin L) from ferrous fumarate (0.5 mM, 24 h) in DMT1 silenced cells was significantly decreased (60% ± 11%) in comparison to iron controls while a 1-h dose of ferrous fumarate (0.5 mM) significantly decreased ferritin L formation in the presence of the clathrin inhibitor chlorpromazine (61% ± 10%, in post-confluent cells and 37% ± 9% in non-confluent cells). …”