Viral UL4 protein promotes pyroptosis in macrophage cells. by Xiaohua Zhang (350570)

Autapses play a crucial role in PV interneuron’s sustained firing at high frequencies. by Sara Hijazi (21656615)

“…Note that in cuprizone mice there was no difference (<i>group x current two-way repeated measures: n = 19,19,18,18 cells from 9−8 mice per group: F(39,856) = 1.671, p = 0.0068, post-hoc LSD test: *p < 0.05</i>). …”

PRV UL4 also promotes AIM2-inflammasome activation. by Xiaohua Zhang (350570)

ssGSEA is employed to analyze immune infiltration in IS and OSA. by Zhe Wu (582498)

Obese <i>mMgat2</i> and <i>HuMgat2</i> mice show defects in Akt insulin signaling. by J. Jose Corbalan (22439198)

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<i>mMgat2</i> and <i>HuMgat2</i> mice become obese when fed a HFD. by J. Jose Corbalan (22439198)

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Under steatotic conditions, primary <i>mMgat2</i> and <i>HuMgat2</i> hepatocytes induce apoptosis. by J. Jose Corbalan (22439198)

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The UL4 mutation alleviates inflammasome activation and pyroptosis in PRV-infected cells. by Xiaohua Zhang (350570)

The UL4 mutation alleviated inflammasome activation and pyroptosis in PRV-infected cells. by Xiaohua Zhang (350570)

Magnification x2 of Fig 1B. by Huan W. Yang (19746645)

“…At 5 dpi, there was a significant increase in p65 NF-κB activation, including protein nuclear translocation and phosphorylation, synchronous with the induction of <i>IL-6</i>, <i>IFN-γ</i> and <i>IL-8</i> expression in <i>L</i>. …”

The UL4 mutation alleviated inflammation in PRV-infected mice. by Xiaohua Zhang (350570)

The UL4 mutation alleviates inflammation in PRV-infected pigs. by Xiaohua Zhang (350570)

Expression of ClC-1. by Rie Asayama (693361)

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PRV UL4 is a promotor of NLRP3 inflammasome Activation. by Xiaohua Zhang (350570)

Sequence of UL4 is involved in inflammasome activation. by Xiaohua Zhang (350570)

Data for Fig 6D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Data for Fig 5D. by Xiaohua Zhang (350570)

“…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (¹³²DVAADAAAEAAAAE¹⁴⁵) mutated strain (PRV-UL4^mut) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”

Amorphous Silica/NaNbO₃ Crystal Heterophase Junction-Supported Ru Catalyst with Optimized Surface and Electron Structure for Highly Efficient Hydrogenation of α‑Pinene... by Haozhang Xu (21366415)

“…On the basis of this, the supported Ru catalyst displayed superior performance for α-pinene hydrogenation with almost complete conversion, <i>cis</i>-pinane selectivity, and good stability. …”

PRV UL4 augments ASC oligomerization and speck formation. by Xiaohua Zhang (350570)

PRV UL4 protein facilitates ASC oligomerization and speck formation by promoting ASC phosphorylation. by Xiaohua Zhang (350570)