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significantly impact » significant impact (Expand Search), significantly improve (Expand Search), significantly improved (Expand Search)
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3981
Data Sheet 1_Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer.zip
Published 2025“…Background<p>High-grade serous ovarian cancer (HGSOC) poses significant treatment challenges due to frequent recurrence and resistance to conventional therapies. …”
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3982
Supplementary file 2_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc
Published 2025“…However, it exerted no significant impact on the levels of LVIDs and LVIDd in the model.…”
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3983
Data Sheet 2_Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer.zip
Published 2025“…Background<p>High-grade serous ovarian cancer (HGSOC) poses significant treatment challenges due to frequent recurrence and resistance to conventional therapies. …”
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3984
Data Sheet 1_Analysis of temporal and spatial changes in the global burden of hypertensive heart disease based on data from the Global Burden of Disease study database and future p...
Published 2025“…According to the APC model, the worldwide incidence of hypertensive heart disease is expected to increase from 2022 to 2046, with further decreases in deaths and DALYs.</p>Conclusions<p>This study systematically reveals the increasing trend in the incidence of hypertensive heart disease globally between 1990 and 2021 and confirms the significant impact of sex and socioeconomic development level on its burden. …”
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3985
Supplementary file 1_EEG activity over ipsilateral and contralateral M1 during simple and complex hand tasks: variations with motor learning.docx
Published 2025“…However, after 10 training sessions, the electrodes over iM1 activation increased during complex tasks but decreased during simple task for both hands, eliminating significant differences in activation levels between simple and complex tasks. …”
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3986
Data Sheet 1_Past and future trends in swiss snow cover: multi-decades analysis using the snow observation from space algorithm.docx
Published 2025“…Under the more extreme scenario (RCP 8.5), snow-free regions could increase by over 43%, with significant impacts during the transitional months of April and May. …”
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3987
Supplementary file 1_Past and future trends in swiss snow cover: multi-decades analysis using the snow observation from space algorithm.docx
Published 2025“…Under the more extreme scenario (RCP 8.5), snow-free regions could increase by over 43%, with significant impacts during the transitional months of April and May. …”
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3988
Image 3_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif
Published 2025“…This study examines MNAM supplementation’s impact on SIRT1 expression and ARHL in low-fat diet (LFD)-fed B6 and CBA mice. …”
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3989
Image 5_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif
Published 2025“…This study examines MNAM supplementation’s impact on SIRT1 expression and ARHL in low-fat diet (LFD)-fed B6 and CBA mice. …”
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3990
Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif
Published 2025“…This study examines MNAM supplementation’s impact on SIRT1 expression and ARHL in low-fat diet (LFD)-fed B6 and CBA mice. …”
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3991
Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif
Published 2025“…This study examines MNAM supplementation’s impact on SIRT1 expression and ARHL in low-fat diet (LFD)-fed B6 and CBA mice. …”
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3992
Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif
Published 2025“…This study examines MNAM supplementation’s impact on SIRT1 expression and ARHL in low-fat diet (LFD)-fed B6 and CBA mice. …”
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3993
DataSheet1_Accumulation of coumaric acid is a key factor in tobacco continuous cropping obstacles.docx
Published 2024“…Introduction<p>Phenolic acids are believed to play a significant role in tobacco continuous cropping obstacles, but the strength and potential mechanisms of different phenolic acids remain unclear.…”
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3994
Supplementary file 1_Characterization of the gut microbiota in people with different levels of obesity.docx
Published 2025“…</p>Results<p>In obese populations, the gut microbiome structure shifted significantly, with beneficial genera like Faecalibacterium, Roseburia, and Ruminococcus decreasing, and potentially harmful genera such as Blautia, Collinsella, and Streptococcus increasing. …”
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3995
Supplementary file 1_Saltmarsh reclamation enhances plant species richness and reduces soil macrofaunal biomass by regulating soil properties through elevation.docx
Published 2025“…<p>Globally, saltmarsh reclamation results in significant losses of coastal wetlands. However, the impacts on above- and below-ground biodiversity and the underlying mechanisms remain poorly understood. …”
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3996
Table 1_Executive functions in post-traumatic stress disorder: their relation to PTSD severity and daily functioning.pdf
Published 2025“…</p>Results<p>Difficulties in executive functions were significantly more prevalent in PTSD patients: the BRIEF-A reflected how executive function difficulties manifested in behavioral dysregulation, restricting daily functioning. …”
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3997
Table1_The long-term prognostic implications of free triiodothyronine to free thyroxine ratio in patients with obstructive sleep apnea and acute coronary syndrome.jpg
Published 2024“…The FT3/FT4 ratio between OSA and non-OSA patients was not significantly different. During 2.8 (1.4, 3.5) years follow up, the risk of MACCE increased with the decreasing FT3/FT4 tertiles in patients with OSA (tertile3 as reference, tertile2: hazard ratio (HR) 1.26, 95% CI: 0.85-1.86, P = 0.255; tertile1: 1.60, 95% CI 1.11-2.32; P = 0.013). …”
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3998
Supplementary Material for: DOT1L regulates cellular senescence during the progression from acute kidney injury to chronic kidney disease via the micro-222-5p/WNT9B signaling pathw...
Published 2025“…Results: The results demonstrated that in vivo inhibition of DOT1L significantly reduced cellular senescence and improved renal tubular injury and interstitial fibrosis. …”
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3999
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis
Published 2025“…Additionally, low mechanics significantly diminishes NCOA4, pivotal in mediating FTH1 phase separation-induced ferritinophagy. …”
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4000
Data Sheet 1_Speaker-story mapping as a method to evaluate audiovisual scene analysis in a virtual classroom scenario.pdf
Published 2025“…Results indicate that the experimental condition significantly influenced task performance, mental load, and user behavior but did not affect perceived simulator sickness and presence. …”