Supplementary Material for: m6A eraser FTO promotes ATF3 expression impairing podocyte autophagy in diabetic nephropathy by figshare admin karger (2628495)

“…Diabetic nephropathy (DN) is characterized by podocyte injury and proteinuria, in which impaired autophagy is a key pathological contributor. …”

Alp5a and Alp5b are not individually required for asexual blood stage propagation, but simultaneously, they are indispensable for parasite viability. by Aastha Varshney (22601181)

Image 2_Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.tif by Viana Q. Pham (22081163)

“…In both ME and AP, adult tanycytes expressed high levels of Ptn and have processes in close contact with fenestrated capillaries. Significantly, the adaptive regulation of Ptn expression and the ability to modulate fenestrated capillaries and vascular permeability were abolished in both ME and AP of aged animals. …”

Image 1_Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.tif by Viana Q. Pham (22081163)

“…In both ME and AP, adult tanycytes expressed high levels of Ptn and have processes in close contact with fenestrated capillaries. Significantly, the adaptive regulation of Ptn expression and the ability to modulate fenestrated capillaries and vascular permeability were abolished in both ME and AP of aged animals. …”

The six most abundant miRNAs within AdMSC-EVs. by Xiaoqin Li (1399105)

“…<div><p>Corneal diseases are a leading cause of visual impairment, and their treatment remains challenging. …”

Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf by Faruk Hossen (20275670)

“…In the cerebral cortex and hippocampus of 12-months-old 3xTg-AD mice, we observed an upregulation of phosphorylated cPLA2 (p-cPLA2), accompanied by downregulation of Cav-1 and impaired insulin signaling. Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”

Scatterplots of respiratory rate and age by sex. by Ina-Maria Rückert-Eheberg (2824901)

“…In an adjusted logistic regression model, age, abdominal obesity, diabetes, COPD, smoking, and low education were significantly associated with elevated respiratory rate. …”

Flow chart of the study population. by Ina-Maria Rückert-Eheberg (2824901)

“…In an adjusted logistic regression model, age, abdominal obesity, diabetes, COPD, smoking, and low education were significantly associated with elevated respiratory rate. …”

Data Sheet 1_Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival.docx by Yanlin Wang (110566)

“…Interestingly, although the downregulation of the PI3K/AKT signaling pathway did not reach statistical significance, this vital pro-survival axis may still contribute to Treg impairment in pSS.…”

Data Sheet 1_Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts.docx by Rui Sun (177521)

“…Tcirg1 deficiency in knockout mice delayed OA progression, as evidenced by reduced cartilage damage, improved subchondral bone mass, and decreased osteoclast activity. In vitro, Tcirg1 expression increased during osteoclast differentiation, and its knockdown inhibited osteoclast fusion and bone resorption by impairing lysosome acidification and peripheral accumulation.…”

DataSheet4_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…Although Trio^{fl/fl; Pcp2-Cre} mice showed significant impairments of spontaneous locomotion activity in both 12-week and 20-week ages, only the 20-week but not 12-week Trio^{fl/fl; Pcp2-Cre} mice showed extra mild abnormal motor, fine motor coordination, and gait. …”

DataSheet5_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…Although Trio^{fl/fl; Pcp2-Cre} mice showed significant impairments of spontaneous locomotion activity in both 12-week and 20-week ages, only the 20-week but not 12-week Trio^{fl/fl; Pcp2-Cre} mice showed extra mild abnormal motor, fine motor coordination, and gait. …”

DataSheet1_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…Although Trio^{fl/fl; Pcp2-Cre} mice showed significant impairments of spontaneous locomotion activity in both 12-week and 20-week ages, only the 20-week but not 12-week Trio^{fl/fl; Pcp2-Cre} mice showed extra mild abnormal motor, fine motor coordination, and gait. …”

DataSheet3_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…Although Trio^{fl/fl; Pcp2-Cre} mice showed significant impairments of spontaneous locomotion activity in both 12-week and 20-week ages, only the 20-week but not 12-week Trio^{fl/fl; Pcp2-Cre} mice showed extra mild abnormal motor, fine motor coordination, and gait. …”

DataSheet2_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…Although Trio^{fl/fl; Pcp2-Cre} mice showed significant impairments of spontaneous locomotion activity in both 12-week and 20-week ages, only the 20-week but not 12-week Trio^{fl/fl; Pcp2-Cre} mice showed extra mild abnormal motor, fine motor coordination, and gait. …”

Data Sheet 1_Electroacupuncture treatment can improve cognitive impairment in spontaneously hypertensive rats: a preliminary DTI study.docx by Ji-peng Liu (14764009)

“…Background<p>Hypertension is a significant risk factor for cognitive impairment. Our group’s previous rs-fMRI study has found that acupuncture can enhance the functional connectivity of brain regions related to cognitive function, thereby protecting the cognitive function of spontaneously hypertensive rats (SHRs).…”

Data Sheet 1_The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis.pdf by Xiangyu Zhao (1497469)

“…</p>Results<p>Olfactory loss not only causes a significant decrease in food intake and body weight and an increase in O₂ consumption but also induces cognitive impairment and anxiety behavior. …”

Supplementary file 1_Resting-state EEG alterations and cognitive impairment in atrial fibrillation: insights into neural biomarkers and functional connectivity.docx by Min-qiang Bao (21570074)

“…</p>Results<p>AF patients had significantly lower MoCA scores. PSD analysis showed increased δ and θ and decreased α and β activity. …”

GnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression by Jun Tan (46388)

“…</i> 56.1%, <i>p</i> < .001) in the GnRH-ant group were significantly decreased. Contrarily, the rate of early miscarriage in the GnRH-ant group (13.95% <i>vs.…”

Table 1_Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study.docx by Ranran Bi (20505614)

“…The OR for significant impairment of ADLs was 0.680 (95% CI: 0.568–0.814, p < 0.001) in participants with serum albumin levels <38.0 g/L. …”