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significantly impair » significantly impairs (Expand Search), significantly impaired (Expand Search), significantly impact (Expand Search)
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1101
Supplementary data.xlsx
Published 2025“…Here, we report for the first time that NAD+ levels are significantly lower in blastocysts cultured in vitro than that in blastocysts developed in vivo, leading to impaired Sirt6 function, further triggering telomere shortening of the inner cell mass and possibly affecting newborn offspring. …”
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1102
TNC promotes bone regeneration via inflammatory macrophage
Published 2024“…Transplantation of macrophages derived from injured periosteum is able to rescue the decreased skeletal stem cells and impaired bone regeneration caused by TNC deficiency. …”
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1103
Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia
Published 2024“…<p>Loss of sense of smell is a cardinal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP) and significantly impacts health-related quality-of-life. …”
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1104
Data Sheet 1_Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease.pdf
Published 2025“…The apoptotic cell death marker cleaved caspase-3 immunoreactive (Caspase-3-IR) percentage in orexin-IR neurons was significantly higher in Tg-SwDI mice than in WT controls. …”
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1105
Functional assays of neurotoxicity testing of α-terpineol in Wistar rats
Published 2025“…The research found that exposure to α- terpineol led to several adverse effects, such as reduced body weight, impaired motor coordination, and significant declines in sperm parameters and testosterone levels. …”
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1106
Supplementary Material for: Fibrillin-1 deficiency perturbs aortic cholinergic relaxation and adrenergic contraction in a mouse model of early onset progressively severe Marfan syn...
Published 2025“…Results: Isometric force measurements of aortic rings from 16-day-old male Fbn1mgR/mgR mice revealed a significant reduction in acetylcholine (ACh)-induced relaxation and increased phenylephrine (PE)-promoted contractility, associated with abnormally low eNOSSer1177 phosphorylation, decreased NO production and augmented superoxide levels. …”
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1107
DataSheet1_Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates.pdf
Published 2024“…Introduction<p>Premature and low-birthweight infants are at especially high risk of perinatal complications, including impaired thermoregulation, infections and respiratory distress. …”
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1108
Data Sheet 1_Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy.pdf
Published 2025“…Wound healing and transwell assays demonstrated that Andro (5 and 20 μM) treatment significantly reduced the wound healing rate and impaired the migratory and invasive abilities of chondrosarcoma cells after 24 hours (p<0.05) compared to controls. …”
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1109
Table 1_Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis.do...
Published 2025“…By week 20, progressive multifocal opacities emerged alongside reduced pulmonary artery flow, impaired lung function, elevated TNF-α/VEGF, and decreased WBC, lymphocytes, and platelets. …”
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1110
Supplementary file 1_Mechanism of soil microbial community degradation under long-term tomato monoculture in greenhouse.docx
Published 2025“…<p>Tomato (Solanum lycopersicum L.), an economically significant crop, is frequently cultivated in greenhouses under continuous monoculture systems. …”
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1111
Table 1_Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach.docx
Published 2024“…Furthermore, INRs exhibited significant alterations in functional connectivity in the temporal and occipital gyrus. …”
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1112
qorA associated data
Published 2025“…Notably, the <i>qorA</i> mutant exhibited impaired survival against neutrophil killing as well as reduced viability in human blood, plasma, and during mouse bloodstream infections, along with a significant decline in its anti-phagocytic capability. …”
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1113
Development and validation of an ultra-performance liquid chromatography with tandem mass spectrometry method for determination of soluble repulsive guidance molecule A in human se...
Published 2024“…</p> <p>In CSF from patients with MCI and those with AD, total soluble RGMa was significantly decreasing to a median of 22.6 and 21.4 ng/ml, respectively.…”
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1114
Low temperature reduces byssus adhesion of highly invasive golden mussels: Influencing mechanisms and antifouling implications
Published 2025“…Our results showed that low-temperature exposures significantly reduced adhesion rates of golden mussels, primarily by limiting byssus production associated with impaired synthesis and secretion of byssal proteins and decreasing byssus breaking force. …”
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1115
Semaglutide ameliorates diabetes-associated cognitive dysfunction in mouse model of type 2 diabetes
Published 2025“…<p dir="ltr"><b>Background:</b> Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction, which significantly impacts the quality of life. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has shown potential neuroprotective effects. …”
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1116
Supplementary Material for: Bidirectional Impact of Varying Severity of Acute Kidney Injury on Calcium Oxalate Stone Formation
Published 2024“…Transcriptomic analysis revealed that genes associated with inflammation and cell adhesion pathways were significantly upregulated after severe AKI, while genes related to energy metabolism pathways were significantly upregulated after mild AKI. …”
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1117
Image 1_Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.jpeg
Published 2025“…It also increased mitochondrial function and ATP levels, reduced intracellular reactive oxygen species, and elevated intracellular GSH levels in both oocytes and embryos. Moreover, FMN significantly decreased autophagy and apoptosis levels in blastocyst cells, potentially via regulation of the Nrf2/Keap1 pathway. …”
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1118
Supplementary Material for: Pharmacokinetic Properties of Dapagliflozin in Patients with Stage 4 Chronic Kidney Disease
Published 2025“…In conclusion, no clinically significant accumulation of dapagliflozin was observed in patients with stage 4 CKD.…”
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1119
Table 1_Evaluation of IVIM and FACT imaging for early detection of rotator cuff muscle degeneration and physiotherapy exercise effects.docx
Published 2025“…Additionally, the change in D* and f correlated with CS, ASES scores and VAS scores respectively. FF showed a decreasing trend but lacking significance (p > 0.05).…”
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1120
Table 1_Comparative study of brain activity and functional connectivity in blepharospasm and blepharospasm-oromandibular dystonia.doc
Published 2025“…Clinical scores of BSP severity were significantly correlated with dALFF in some of these important regions.…”