Effects of Semaglutide and Dapagliflozin on Neuronal Integrity, Apoptosis, and LRP1 Expression in the Hippocampal CA1 Region of T2DM Mice. حسب Yan Zhu (112437)

Metabolic characteristics of T2DM mice. حسب Yan Zhu (112437)

"…<div><p>Background</p><p>Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction, which significantly impacts the quality of life. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has shown potential neuroprotective effects. …"

Schematic diagram of the study design. حسب Yan Zhu (112437)

"…<div><p>Background</p><p>Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction, which significantly impacts the quality of life. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has shown potential neuroprotective effects. …"

Data Sheet 1_Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner.docx حسب Moriah R. Arnold (20908868)

The minimal anonymized data set. حسب Zufan Alamrie Asmare (16474982)

"…Therefore, improvement of post-operative visual outcome through decreasing intra-operative complications, managing post-operative complications, and investing in specialized training and equipment for ophthalmic surgeons are pivotal and need significant emphasis.…"

Video 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 5_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 6_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Data Sheet 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 4_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Data Sheet 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

"…Multi-omics analysis revealed that TPC2 KO disrupted amino acid metabolism, glycolysis, and protein translation, resulting in reduced ERK1/2 expression and impaired MAPK signalling. These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…"

Image 2_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi... حسب Jialin Yu (131558)

"…While an association with increased risk of cognitive impairment was observed, it was not statistically significant. …"

Table 1_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi... حسب Jialin Yu (131558)

"…While an association with increased risk of cognitive impairment was observed, it was not statistically significant. …"

Image 1_Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysi... حسب Jialin Yu (131558)

"…While an association with increased risk of cognitive impairment was observed, it was not statistically significant. …"

Data Sheet 1_Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study.docx حسب Kaiyue Han (11743982)

"…Background<p>Cognitive impairment is a common dysfunction following stroke, significantly affecting patients’ quality of life. …"

Mechanisms underlying the therapeutic potential of time-restricted eating in Huntington’s disease. حسب Russell G. Wells (20933789)

Data Sheet 1_Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation.xlsx حسب Jianwei Peng (811819)

"…This study investigates how aerobic exercise affects cognitive impairments caused by AS in ApoE^−/− mice. …"