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17941
Table 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx
Published 2025“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”
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17942
Image 2_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.pdf
Published 2025“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”
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17943
Table_1_Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy.docx
Published 2024“…In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). …”
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17944
Table_2_Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy.xlsx
Published 2024“…In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). …”
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17945
Figure 4 from Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells
Published 2025“…<i>Plp1-creERT</i>/+; <i>R26-fs-GNAQ</i><sup><i>Q209L</i></sup>/+; +/+ mice. There was a significantly decreased tumor-free survival in <i>Plp1-creERT</i>/+; <i>R26-fs-GNAQ</i><sup><i>Q209L</i></sup>/+; <i>Nf1</i><sup><i>flox</i></sup>/+ mice. n.s., not significant.…”
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17946
Image 1_Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegenerati...
Published 2025“…Lipidomic analysis highlighted substantial alterations in lipid composition, with significant decreases in sphingomyelins, phosphatidylethanolamine, and phosphatidylcholine, reflecting disruptions in lipid metabolism and membrane integrity. …”
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17947
Data Sheet 1_CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint.docx
Published 2025“…Background<p>Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence underscoring its significance in cancer immunotherapy. The complex pathogenesis and therapeutic resistance characteristic of liver hepatocellular carcinoma (LIHC) present significant challenges in clinical practice. …”
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17948
Data Sheet 1_The socio-cultural implications of glacier retreat demand further attention: a case study from Cerro El Plomo in Santiago, Chile.pdf
Published 2025“…The Cerro El Plomo glaciers are arguably the most visible and socio-culturally significant in the Santiago region. Satellite imagery analysis and prior studies show that the total area of Cerro El Plomo glaciers has decreased by 17% ± 6% since 2000 and their mass balance has become increasingly more negative, particularly after the onset of the Central Andes megadrought in 2010. …”
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17949
<b>Seizure-induced changes in cytokine expression and dysregulation of plasminogen activation and IGF systems following kainic acid administration in rats</b>
Published 2025“…We also observed disruption of the IGF system, characterized by decreased IGFBP-5 protein levels in the hippocampus and downregulation of <i>Igfbp5</i> mRNA in both hippocampus and cortex. …”
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17950
Table_2_Microclimate shapes the phylosymbiosis of rodent gut microbiota in Jordan’s Great Rift Valley.XLSX
Published 2025“…We found that bioclimatic zone had a significant effect on the gut microbiota composition while host phylogeny did not. …”
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17951
Supplementary Material for: The power of a good word: Enhancing the efficacy of analgesics in clinical settings
Published 2024“…In study 2, in the last two timepoints of assessment, participants in the EC arm also consumed fewer doses of opioids than participants in the RC arm (p<0.001). No significant differences were found in vital signs. Conclusions: We provide ecological evidence that positive information about treatment significantly decreases pain and opioid consumption during routine clinical care. …”
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17952
Surface Modification of Islets with L-DOPA-KF7 Enhances Islet Survival by Inhibiting IBMIR in Intrahepatic Islet Transplantation
Published 2025“…Islets coated with L-DOPA-KF7 restored normoglycemia in diabetic mice, and survival time was significantly longer compared to control group. Transplantation of L-DOPA-KF7 coated islets was associated with reduced blood clot formation and decreased infiltration of CD11b+ cells and platelets. …”
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17953
Table 1_Jump performance and handgrip strength do not reflect acute fatigue in elite trail runners after the 2023 world trail running championship.xlsx
Published 2025“…Handgrip strength test analyses showed no significant reductions post-run.</p>Conclusion<p>RSI decreased while other performance variables remained unchanged. …”
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17954
Supplementary file 1_Structural and functional disconnections in non-acute post-stroke patients.docx
Published 2025“…</p>Results<p>Compared with HCs, significant decreases in both SC and FC were observed in stroke patients among the right precentral gyrus, right superior frontal gyrus, right supplementary motor area, right paracentral lobule, right middle cingulate gyrus, right superior marginal gyrus, right middle temporal gyrus, and left inferior temporal gyrus. …”
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17955
Table 3_Global, regional, and national burden of acute hepatitis (1990–2021): a systematic analysis of the global burden of disease in 2021.xlsx
Published 2025“…</p>Conclusion<p>While global AVH burden is decreasing, significant disparities persist, warranting tailored interventions to enhance resource equity in high-SDI regions and strengthen healthcare infrastructure in low-SDI areas.…”
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17956
Data Sheet 1_Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection in vitro.pdf
Published 2025“…Infection and adhesion assays demonstrated a significant reduction in infection levels, suggesting that DHP/Alg directly targets Chlamydia elementary bodies, thereby disrupting their ability to adhere and initiate infection. …”
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17957
Table 1_A real-world disproportionality analysis of ripretinib data mining of the public version of FDA adverse event reporting system.docx
Published 2025“…Notably, the label includes unexpected and significant AEs such as “hepatic neoplasm”, “hair texture abnormal”, “metastases to liver” and “red blood cell count decreased”. …”
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17958
Table 2_Global, regional, and national burden of acute hepatitis (1990–2021): a systematic analysis of the global burden of disease in 2021.xlsx
Published 2025“…</p>Conclusion<p>While global AVH burden is decreasing, significant disparities persist, warranting tailored interventions to enhance resource equity in high-SDI regions and strengthen healthcare infrastructure in low-SDI areas.…”
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17959
Table_1_Microclimate shapes the phylosymbiosis of rodent gut microbiota in Jordan’s Great Rift Valley.XLSX
Published 2025“…We found that bioclimatic zone had a significant effect on the gut microbiota composition while host phylogeny did not. …”
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17960
Supplementary file 1_Clinical utility of the PBAC score in quantifying treatment response to hysteroscopy: a retrospective observational study.docx
Published 2025“…Data were analyzed using SPSS version 26, and p < 0.05 was considered statistically significant.</p>Results<p>Of the 327 patients included in the study, 91.1% had a baseline PBAC score ≥100, which significantly decreased following hysteroscopy (mean reduction: 393 points; p < .001). …”