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12521
Table 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls
Published 2025“…</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …”
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12522
Data Sheet 4_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf
Published 2025“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca<sup>2+</sup> levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”
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12523
Image2_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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12524
Data Sheet 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.zip
Published 2025“…</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …”
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12525
Changes in dorsal-ventral patterning of CA1 in COUP-TFI mutant hippocampus.
Published 2025“…The Dcn/Wfs1 ratio was significantly decreased in the cKO and increased in the cTG. …”
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12526
Data Sheet 3_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf
Published 2025“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca<sup>2+</sup> levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”
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12527
Table 5_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls
Published 2025“…</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …”
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12528
Inference of cell-type proportions from bulk RNAseq and dynamics during myocardial infarction in α1A-AR-KO mice.
Published 2025“…<b>(D)</b> Estimation of cardiac cell type composition changes post-myocardial infarction (MI) and in α1A-AR knockout (cmAKO) mice, showing increased proportions of macrophages and fibroblasts and decreased proportions of cardiomyocytes, with more pronounced changes in cmAKO mice. …”
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12529
Image 1_Oral supplementation with Lactobacillus fermentum MC018 improves intestinal health, immune response, and growth performance of Zi geese infected with Escherichia coli XH197...
Published 2025“…Introduction<p>Escherichia coli infection causes severe diarrhea, decreases growth performance, and increases mortality of poultry, which imposes a significant economic burden on the poultry industry and severely limits its growth.…”
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12530
Table 2_Oral supplementation with Lactobacillus fermentum MC018 improves intestinal health, immune response, and growth performance of Zi geese infected with Escherichia coli XH197...
Published 2025“…Introduction<p>Escherichia coli infection causes severe diarrhea, decreases growth performance, and increases mortality of poultry, which imposes a significant economic burden on the poultry industry and severely limits its growth.…”
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12531
Table 1_Oral supplementation with Lactobacillus fermentum MC018 improves intestinal health, immune response, and growth performance of Zi geese infected with Escherichia coli XH197...
Published 2025“…Introduction<p>Escherichia coli infection causes severe diarrhea, decreases growth performance, and increases mortality of poultry, which imposes a significant economic burden on the poultry industry and severely limits its growth.…”
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12532
Identifying cyst initiation candidate genes through mRNA sequencing <i>Pkd2</i> mouse kidneys at pre-cystic and early cystic time points.
Published 2024“…Colored dots indicate FDR <0.05, red indicates increased and blue decreased in Experimental vs Control. …”
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12533
Table 1_Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule.docx
Published 2025“…After XFC treatment, FTO, ENST00000619282, and Bcl-2 expressions were decreased, while YTHDF1 and Bax expressions were increased (all P<0.05). …”
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12534
Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc
Published 2025“…Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …”
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12535
Table 1_Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study.docx
Published 2025“…</p>Results<p>After 48 months, TUG time decreased by −3.8 s (95% CI: −5.0 to −2.6; p < 0.001; dz = −1.12) and 6MWT distance increased by +88.8 m (95% CI: 45.1 to 133.0; p < 0.001; dz = 0.72), both exceeding MDC thresholds. …”
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12536
Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRP...
Published 2025“…The right shifts of the peaks in the MDA-MB468, BT549, and Hs578T sensitive cell lines indicate increased permeability. <b>B,</b> Flow cytometric mitochondrial membrane potential (MT-1) assay. …”
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12537
DataSheet1_Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway.docx
Published 2025“…Introduction<p>Chronic kidney disease (CKD) is a chronic progressive disease characterized by abnormalities in kidney structure or function caused by variousfactors. It has become a significant public health problem, posing a threat to human health worldwide. …”
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12538
Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf
Published 2025“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”
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12539
Table 5_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa...
Published 2025“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”
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12540
Tectonic and metallogenic processes along the east Tethyan metallogenic domain (Lhasa-southern Tibet, Kohistan island arc and Chagai magmatic belt): a perspective review
Published 2025“…In the Lhasa terrane, fertile Miocene adakite-like intrusions originated from partial melting of thickened mafic lower crust, while ore-barren adakite characterized by relatively lower εNd(t), higher <sup>87</sup>Sr/<sup>86</sup>Sr(i), and decreased fluid-sensitive element ratios (Ba/La, Pb/Ce, Sr/Nd), indicating reduced slab-derived fluid input and increased contributions from ancient basement crust. …”