Supplementary information files for "Incorporating fluid-structure interactions for modelling of pyramidal hollow microneedles for transdermal drug delivery" by Rahul Nadda (19435999)

“…As expected, SS demonstrated the lowest von Mises stress (13 213 N/m2 ) while PLA and PGA exhibited a decrease in the stress level as the HMN wall thickness increased. …”

Table 4_Is takeout culture associated with rising colorectal cancer in young Chinese adults? An ecological analysis of GBD and CHNS data.xlsx by Ling Yao (16961)

“…Among non-neoplastic digestive diseases, inflammatory bowel disease showed the most pronounced decrease. In contrast, the burden of colorectal cancer has increased annually across all age groups. …”

Data Sheet 1_Characterization of vaginal microbiota across female reproductive phases.zip by Qingzhi Zhai (21265412)

“…Firmicutes dominate in the early reproductive phases but decrease notably during lactation and menopause. Conversely, Bacteroidetes, Actinobacteria, and Proteobacteria increase in later phases. …”

Table 1_Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreatio... by Dawna Salter (18498396)

“…Blood and urine samples collected at baseline, before, and after DHR were analyzed for inflammation-related biomarkers. VAS scores significantly increased while muscle strength decreased from baseline measures after DHR regardless of group assignment (main effect of time p < 0.001). …”

Data_Sheet_1_Effects of household solid fuel use on sarcopenia in middle-aged and older adults: evidence from a nationwide cohort study.docx by Shaohui Su (19779057)

“…</p>Conclusion<p>Household use of solid fuels is associated with an increased risk of sarcopenia. Restricting the use of solid fuels and focusing on cognitive function and depressive symptoms in solid fuel users can help decrease sarcopenia development.…”

Table 1_Secular trends of vitamin D and calcium intake and their circulating levels in US adults from 2007 to 2018.docx by Yongliang Du (4751808)

“…Serum total calcium significantly decreased with survey years from 2007 to 2018 (9.42 to 9.31 mg/dL) (P trend <0.001). …”

Data Sheet 1_Combined effect of esaxerenone and dapagliflozin on aldosterone-mediated sodium reabsorption and potassium excretion.docx by Motonobu Nakamura (5944421)

“…TWIK-1 expression did not significantly decrease in rats continuously treated with ESX and Dapa compared with that in rats treated with ESX alone.…”

Conservation in a changing world: assessing the conservation status of an agruculturally adapted species, the Blue Crane. Chapter 2: Population Trends by Christie Craig (21008186)

“…Flock sizes were significantly larger in the Karoo than the Western Cape, with flocks up to 1200 counted on irrigated lucerne fields. …”

Effects of building morphology on land surface temperature in Xi'an City – insights based on different settlement types and seasons by Le Xuan (22471548)

“…In summer, MBH has a cooling effect across most layouts, except for P-L. A 5% increase in BCR raises temperatures by 0.1 °C–0.3 °C in summer, while in autumn, MBH becomes the most significant cooling factor, with a 3-meter increase reducing temperatures by 0.01 °C–0.06 °C. …”

Data Sheet 1_Temporal and spatial variability of S-wave and coda attenuation in the Central Apennines, Italy.docx by Simona Gabrielli (11473572)

“…Our results showed a 13% variation in S-wave attenuation between the pre-sequence (2011–2016) and the sequence phase, with a significant 37% decrease in Q (increase in attenuation) detected during the Visso period. …”

Image 1_Impacts of the Xisha topography on the far-field internal solitary waves.jpeg by Hanyu Chen (2735152)

“…While approaching the shallow-water sill of the Xisha Islands, those far-field first-mode ISWs undergo amplitude reduction and significant phase shift because of their collision with local generated ISWs in the Xisha sea area, while their phase speed increases and decreases due to the increase and decrease of the water depth, respectively. …”

Supplementary file 1_The influence of spousal care on the health of middle-aged and older adult caregivers in China—empirical analysis based on CHARLS data.docx by Rui Wang (52434)

“…Objectives<p>With the decrease of the number of children and the increase of population mobility, child care presents a phenomenon of “double shortage” of human and time resources, and spousal care is becoming an important care source for middle-aged and older adult people in China. …”

Table 1_Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients.xlsx by Xiaoyan Fu (5578187)

“…Post-chemotherapy, patients with positive responses demonstrated an increase in Clostridium and Microbacterium species, along with a decrease in Streptococcus and Neisseria. …”

Supplementary file 1_Taxonomic and functional shifts in soil nematode communities following estuarine island reclamation.docx by Sufeng Pan (21460022)

“…We collected data on the morphological and life history traits of soil nematodes, including body size, cephalic setae, amphids, tail shape, life history strategy, and feeding habit, to assess the functional responses of nematodes to different reclamation stages. We found a significant decrease in both taxonomic and functional diversity as tidal flats were converted to dry land, followed by a gradual recovery that progressed with increasing reclamation age. …”

Neutrophil recruitment after <i>H</i>. <i>pylori</i> infection monitored by multiphoton microscopy <i>in vivo</i>. by Hellen Ishikawa-Ankerhold (5900822)

“…<i>pylori</i> infection and decrease after 6 weeks of infection. n = 4 mice. ****p<0.0001, ***p<0.001, **p<0.01, *p<0.05, or not significant (ns). …”

Supplementary tables: Assessing healthcare resource utilization burden and unmet treatment needs in patients with Parkinson’s disease: results from a real-world study by Malgorzata Ciepielewska (22143499)

“…<b>Conclusion: </b>This real-world analysis found significant increases in disease burden and healthcare resource utilization for patients with intermediate versus early PD. …”

Table 3_Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic... by Weifeng Zhen (12969341)

“…ECCO₂R significantly reduced driving pressure (weighted mean difference [WMD]: −3.70 cmH₂O; 95% CI: −4.05 to −3.34; P < 0.001), plateau pressure (WMD: −3.26 cmH₂O; 95% CI: −3.70 to −2.82; P < 0.001), and tidal volume (WMD: −1.68 mL/kg; 95% CI: −1.81 to −1.55; P < 0.001) at 24 h, while it increased positive end-expiratory pressure (WMD: 0.64 cmH₂O; 95% CI: 0.44 to 0.85; P < 0.001). …”

Data Sheet 1_Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.pdf by figshare admin frontiersin (4545187)

“…Additionally, the Cyn intervention group showed significant improvements in both the intestinal barrier structure (elevated tight junction protein levels and proper localization) and function (reduced serum FD4 levels, increased intestinal TEER, and decreased bacterial translocation rates in mesenteric lymph nodes [MLNs] and livers). …”

Table 1_Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic... by Weifeng Zhen (12969341)

“…ECCO₂R significantly reduced driving pressure (weighted mean difference [WMD]: −3.70 cmH₂O; 95% CI: −4.05 to −3.34; P < 0.001), plateau pressure (WMD: −3.26 cmH₂O; 95% CI: −3.70 to −2.82; P < 0.001), and tidal volume (WMD: −1.68 mL/kg; 95% CI: −1.81 to −1.55; P < 0.001) at 24 h, while it increased positive end-expiratory pressure (WMD: 0.64 cmH₂O; 95% CI: 0.44 to 0.85; P < 0.001). …”

Table 2_Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic... by Weifeng Zhen (12969341)

“…ECCO₂R significantly reduced driving pressure (weighted mean difference [WMD]: −3.70 cmH₂O; 95% CI: −4.05 to −3.34; P < 0.001), plateau pressure (WMD: −3.26 cmH₂O; 95% CI: −3.70 to −2.82; P < 0.001), and tidal volume (WMD: −1.68 mL/kg; 95% CI: −1.81 to −1.55; P < 0.001) at 24 h, while it increased positive end-expiratory pressure (WMD: 0.64 cmH₂O; 95% CI: 0.44 to 0.85; P < 0.001). …”