First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

Image 1_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Image 2_Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.jpg by Tianle Cheng (20788417)

“…We identified four neutrophil subtypes—pro-inflammatory, anti-inflammatory, mature, and immature—revealing a significant increase in pro-inflammatory neutrophils in sepsis (40.53% versus 4.19% in controls) and a decrease in anti-inflammatory neutrophils (18.43% versus 27.04%). …”

Data Sheet 1_Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants.docx by Ahmad Chmaisse (8829737)

“…</p>Results<p>40% of patients weaned respiratory support. x-ray haziness change was not significantly different between groups (p = 0.086), however trended toward significance. 59% had decreased haziness and 16% had a marked decrease. …”

Examining cardiac toxicity in HER2-positive breast cancer patients using trastuzumab and its influencing factors at Iran Hospital by Fatemeh Nasri (8290011)

“…The criteria for heart failure in this study were defined as an ejection fraction (EF) of less than 50% or a decrease of greater than 10% in EF. …”

Data Sheet 1_Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized control... by Sumaiah J. Alarfaj (12889115)

“…A clinical response was defined as a decline in the rectal bleeding sub score of at least one point, and a decrease in PMS of at least two points. Clinical remission was defined as a PMS of less than 2 and the absence of any single sub score greater than 1.…”

DataSheet1_Cross-National Trends in Early Sexual Initiation Among 15-Year-Old Adolescents, 2002–2022.xlsx by András Költő (10831323)

“…Parental support (and its interaction with time) also had a significant but small protective role.</p>Conclusion<p>Despite a small decrease over time, still 4% of participants reported early sexual initiation in 2022. …”

Table 1_The association between a dietary index for the gut microbiota and frailty in older adults: emphasising the mediating role of inflammatory indicators.docx by Huangyi Yin (18593848)

“…Furthermore, participants in the highest tertile of the DI-GM were significantly less likely to be frail than were those in the lowest tertile (OR = 0.70; 95% CI: 0.53, 0.91; p = 0.008). …”

Table 1_Evaluation of the clinical application of information-motivation-behavior model care combined with labetalol pharmacotherapy for patients with hypertensive disorders of pre... by Linling Sun (22465585)

“…In addition, the intervention group had a longer gestational week of delivery (p = 0.04), less chance of vaginal delivery to caesarean section (p = 0.048), and a trend towards a decrease in the incidence of adverse pregnancy outcomes such as preterm labor and adverse effects such as nausea, albeit not statistically significant (p > 0.05).…”

Supplementary Material for: The effect of LDL receptor–related protein–1 on acute kidney injury and renal tubular epithelial triglyceride accumulation by figshare admin karger (2628495)

“…However, in the in vitro model, although VLDL increased TG levels in HK-2 cells in both normal culture and hypoxia-reoxygenation conditions, it did not alleviate the decrease in cell viability induced by CCCP. In the absence of exogenous VLDL, silencing LRP1 still reduced CCCP-induced TG accumulation and cell apoptosis, although the reduction in TG levels was less pronounced compared to the presence of exogenous VLDL. …”

Data Sheet 1_Direct and indirect effects of land use on microbiomes of trap-nesting solitary bee larvae and nests.docx by Birte Peters (12323923)

“…The Shannon diversity of bacteria in nest materials (larval pollen provision, soil nest enclosure) and larval guts decreased with increasing land use intensity. However, the pupae microbiome remained unaffected, indicating a reorganization of the microbiome during metamorphosis, which is not significantly influenced by land use and available resources.…”

Data_Sheet_1_Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice.docx by Ana Laura M. R. Tomiyama (16902930)

“…Microglial reactivity quantified by the integrated density of pixels did not decrease with treatment but showed a less activated morphology, coupled with polarization to an M1 profile. …”

Data_Sheet_1_Food service safety and hygiene factors: a longitudinal study on the Brazilian consumer perception.DOCX by Natália Caldeira de Carvalho (19986360)

“…In conclusion, different phases of the COVID-19 pandemic significantly influenced consumer behavior and attitudes toward purchasing ready-to-eat food.…”

Supplementary file 1_Antibiotic pretreatment inhibits white band disease infection by suppressing the bacterial pathobiome.docx by Jason D. Selwyn (2633932)

“…We found the prophylactic use of antibiotics led to significantly reduced infection rates in disease exposed corals with a 30-percentage point decrease in the infection rate. …”