Table 1_Gut microbiome alterations and their clinical and biological implications in ovarian cancer: a systematic review.docx by Beibei Zhang (509356)

“…Following surgery, both Firmicutes and Proteobacteria declined, indicating significant microbiome shifts. During chemotherapy, especially neoadjuvant treatment, Firmicutes re-emerged as the dominant phylum. …”

DataSheet1_Association between changes in thyroid hormones and incident type 2 diabetes using joint models of longitudinal and time-to-event data: more than a decade follow up in t... by Alireza Amirabadizadeh (6399635)

“…Background<p>Type 2 diabetes mellitus (T2DM) poses a significant public health challenge, contributing to considerable morbidity and mortality worldwide, which necessitates urgent preventive measures. …”

Table1_Identification of key biomarkers and therapeutic targets in sepsis through coagulation-related gene expression and immune pathway analysis.docx by Jing Ge (443408)

“…<p>Sepsis, characterized by a widespread and dysregulated immune response to infection leading to organ dysfunction, presents significant challenges in diagnosis and treatment. In this study, we investigated 203 coagulation-related genes in sepsis patients to explore their roles in the disease. …”

Data_Sheet_1_Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease.docx by Fahad Mubariz (16010003)

“…Moreover, treatment with the lipid substrate reducing compound Genz-123346, decreased mTORC1 activity and increased TFEB expression in the mutant neurons, suggesting that mTORC1-TFEB alterations are linked to the lipid substrate accumulation. …”

Data Sheet 1_Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation.pdf by Liling Ma (16752684)

“…In CHB patients with normal ALT but liver inflammation detected on B-scan ultrasonography, a significant decrease was observed in the MMP^low percentage of CD8⁺T (66.13 ± 14.27), CD56⁺NK(57.77 ± 17.40) and CD4^-CD8^-T (61.98 ± 15.98) cells. …”

Data Sheet 1_TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury.zip by Yunsheng Zhang (474242)

“…Spleen tyrosine kinase (SYK) inhibition was achieved using R406, and TREM-1 small interfering RNA (siRNA) and overexpressing plasmids were performed to validate its role in NF-κB signaling and pyroptosis quantified using WB and enzyme-linked immunosorbent assay (ELISA). Quantitative data are expressed as mean ± SD, and group comparisons were made by two-tailed Student’s t-tests or one-way ANOVA with Tukey’s post hoc test, with P < 0.05 considered statistically significant.…”

Tropical volcanic eruptions enhance global tropical cyclone geneses by Jiuwei Zhao (8548263)

“…We find a significant increase in TCGF over the </b><b>Pacific within two years following strong TVEs, accompanied by an insignificant decrease </b><b>over the South Indian Ocean, leading to a net global TCGF increase. …”

Data Sheet 1_Clinical predictors and concomitant antiseizure medications effects on seizure control in relation to plasma cenobamate concentration: a multicenter retrospective stud... by Francesca Felicia Operto (12509263)

“…Its non-linear pharmacokinetics and strong modulation of cytochrome P450 enzymes may significantly affect the metabolism of co-administered ASMs, posing important challenges for polytherapy management. …”

Data Sheet 1_A comparative analysis of cluster based interventions on healthcare-associated infections in a tertiary care hospital in China.doc by Ya Zou (6527423)

“…Additionally, a notable decrease in NSIs per 10,000 patient days was observed during the same comparison period, with a statistically significant difference (12.17 ± 1.47 vs. 9.20 ± 1.07, p = 0.006).…”

Image 1_Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.tif by Lu Liu (171341)

“…., a traditional Chinese botanical drug, has shown significant therapeutic effects against hepatocellular carcinoma (HCC), with its flavonoid compounds exhibiting anti-HCC activity through various mechanisms. …”

The Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics by Kinga Nagy (603019)

“…Our results showed a linear <i>m</i>/<i>z</i> dependence for all enzymes, with Glu-C, Asp-N, and chymotrypsin requiring significantly lower energies than trypsin and Arg-C. …”

Table 1_Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis.docx by Mohamed E. A. Mostafa (19834779)

“…</p>Results<p>The study found that ROSE-010 (100 µg) significantly lowered pain intensity in IBS patients compared to a placebo, with an overall odds ratio of 2.30, 95% CI: 1.53-3.46. …”

Table 2_Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis.xlsx by Mohamed E. A. Mostafa (19834779)

“…</p>Results<p>The study found that ROSE-010 (100 µg) significantly lowered pain intensity in IBS patients compared to a placebo, with an overall odds ratio of 2.30, 95% CI: 1.53-3.46. …”

Table 1_Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach.xlsx by Eman Elgendy (21811052)

“…Background<p>Pain is a multifaceted condition intricately linked to inflammation, which plays a critical role in its onset and progression.…”

Data Sheet 1_The impact of social activity on cardiovascular disease risk among middle-aged and older adults in China: a nationwide cohort study based on the CHARLS database.pdf by Yingting Wu (12215218)

“…</p>Conclusion<p>Social activity is significantly linked to the risk of cardiovascular disease among middle-aged and older adults in China. …”

Axon Degradation of Dorsal Root Ganglion Cells from Laser Ablation Damage in the Presence of Mdiv Inhibitor by Sophia Liu (722004)

“…Results showed that Mdivi-1 treatment significantly reduced cell body degradation, with treated neurons exhibiting a smaller percentage decrease in cell body area compared to untreated controls. …”

Table1_Evaluation of thyroid function tests among children with neurological disorders.docx by Haojie Meng (20400383)

“…Numerous studies have identified significant links between thyroid dysfunction and cognitive function. …”

Continuing evolution of H5N1 highly pathogenic avian influenza viruses of clade 2.3.2.1a G2 genotype in domestic poultry of Bangladesh during 2018–2021 by Mohammed Nooruzzaman (3175290)

“…Consequently, antigenic analysis revealed a significant loss of cross-reactivity between viruses from different host species and periods. …”

Non-Homogeneous Distribution of Inhibitory Inputs Among Motor Units in Response to Nociceptive Stimulation by Francois Hug (6834971)

“…First, while motor unit discharge rates significantly decreased during Pain, a substantial proportion of motor units (14.8-24.8%) did not show this decrease and, in some cases, even exhibited an increase. …”

Data Sheet 1_Antarctic krill habitat suitability variation in the Southern Ocean over 20 years.pdf by Yiyang Tan (18227048)

“…<p>Antarctic krill (Euphausia superba) is a key species that sustains the biodiversity of the Southern Ocean and is a protected and restricted fishing target in this region. Considering the significant impacts of climate change on the ecological environment of the Southern Ocean, it is critical to understand the long-term spatio-temporal habitat distribution of Antarctic krill. …”