Image1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d... by Huijing Ren (19986303)

“…The production of cytokines was evaluated with enzyme-linked immunosorbent assay. The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. …”

Image 2_Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development.tiff by Andrea Di Credico (13137135)

“…Importantly, TUNEL assay confirmed the absence of significant cytotoxicity. BPS exposure was associated with reduced ERβ, GPER, and phosphorylated Akt expression, suggesting a possible involvement of estrogen-related pathways. …”

<b>Gene x environment interactions as drivers of lifespan variation in nematodes</b> by Justin Havird (2812975)

“…Both the genetic strains and phytochemicals were associated with mitochondrial function. We found significant effects of genetic background (although not always as precited from previous studies), chemical treatment, and their interactions (GxE) that explained variation in lifespan. …”

Image 1_Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development.tiff by Andrea Di Credico (13137135)

“…Importantly, TUNEL assay confirmed the absence of significant cytotoxicity. BPS exposure was associated with reduced ERβ, GPER, and phosphorylated Akt expression, suggesting a possible involvement of estrogen-related pathways. …”

Table 1_Serum cortisol level as marker of stress in camels: relationship with immunological profile.xlsx by Jamal Hussen (445435)

“…Female camels exhibited higher cortisol levels compared to males, with non-pregnant and lactating she-camels showing elevated levels relative to their pregnant and non-lactating counterparts. No significant differences in cortisol levels were observed among camel breeds (Majaheem, Magateer, Sawahli, and Omani). …”

Table 1_Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegenerati... by Menekse Oeztuerk (20756606)

“…Lipidomic analysis highlighted substantial alterations in lipid composition, with significant decreases in sphingomyelins, phosphatidylethanolamine, and phosphatidylcholine, reflecting disruptions in lipid metabolism and membrane integrity. …”

Image 1_Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegenerati... by Menekse Oeztuerk (20756606)

“…Lipidomic analysis highlighted substantial alterations in lipid composition, with significant decreases in sphingomyelins, phosphatidylethanolamine, and phosphatidylcholine, reflecting disruptions in lipid metabolism and membrane integrity. …”

Data Sheet 2_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf by Lu Ding (475637)

“…Increased tyrosine, glutamine, phenylalanine, sphingomyelin, glutamate, lactate and glucose, and decreased LysoPC (18:2), histidine, and methionine levels were linked to IS onset. …”

Table 1_Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study... by Shilin Zhong (9588065)

“…</p>Discussion<p>This study suggests that GM of women with GDM undergoes significant alterations between the first and second trimesters, potentially linked to inflammation, with more pronounced changes observed in overweight or obese individuals.…”

Data Sheet 1_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf by Lu Ding (475637)

“…Increased tyrosine, glutamine, phenylalanine, sphingomyelin, glutamate, lactate and glucose, and decreased LysoPC (18:2), histidine, and methionine levels were linked to IS onset. …”

Data Sheet 3_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf by Lu Ding (475637)

“…Increased tyrosine, glutamine, phenylalanine, sphingomyelin, glutamate, lactate and glucose, and decreased LysoPC (18:2), histidine, and methionine levels were linked to IS onset. …”

Data Sheet 4_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf by Lu Ding (475637)

“…Increased tyrosine, glutamine, phenylalanine, sphingomyelin, glutamate, lactate and glucose, and decreased LysoPC (18:2), histidine, and methionine levels were linked to IS onset. …”

Image 1_Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome.jpeg by Mailén Rojo (10802556)

“…Stratifying these patients by metabolic profile, revealed a progressive decline in mtDNA content from the normal-weight control group to the MHO-PCOS and MUO-PCOS groups, suggesting that lower mtDNA content is linked to obesity and worse metabolic profile. However, mtDNA oxidation levels did not differ significantly among these groups. …”

Data Sheet 1_Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy.pdf by Chun-Fei Wu (22315444)

“…Confocal microscopy demonstrated a significant increase in autophagic flux in Andro-treated SW1353 cells. …”

Table 1_Relationship between advanced lung cancer inflammation index and all-cause and cause-specific mortality among chronic inflammatory airway diseases patients: a population-ba... by Zhuanbo Luo (378365)

“…An elevated ALI was significantly related to a decreased risk of all-cause mortality, as well as mortality from cardiovascular and respiratory diseases among CIAD patients. …”

Table 1_Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis.do... by Wu Chen (569414)

“…By week 20, progressive multifocal opacities emerged alongside reduced pulmonary artery flow, impaired lung function, elevated TNF-α/VEGF, and decreased WBC, lymphocytes, and platelets. Compared to untreated controls, 10-week DBD treatment significantly suppressed lung tumor growth, reduced lesion microvessel density, downregulated HIF-1α and VEGF expression, and ameliorated hematological dysregulation.…”

Presentation 1_Integrative analysis of DNA methylation, RNA sequencing, and genomic variants in the cancer genome atlas (TCGA) to predict endometrial cancer recurrence.pptx by Jin Hwa Hong (6523928)

“…Further validation using TCGA clinical data confirmed PARD6G-AS1 hypomethylation and CD44 overexpression as significant indicators of recurrence (p=0.006 and p=0.02, respectively), and both were linked to advanced stage and lymph node metastasis.…”

Table 1_Molecular and epigenetic responses to crowding stress in rainbow trout (Oncorhynchus mykiss) skeletal muscle.xlsx by Daniela Aravena-Canales (14336037)

“…Background<p>Chronic stress is a critical challenge in fish aquaculture, adversely affecting growth, health, and overall productivity. Among the most significant chronic stressors in intensive farming is crowding, which triggers the release of cortisol, the primary stress hormone in fish. …”

Presentation1_Exchange flow in a highly stratified fjord in drought conditions.pdf by Elias Pinilla (20400329)

“…Logistic regression models showed significant links between stratification levels and harmful algal blooms (HABs) of Pseudchatonella spp. and Alexandrium catenella. …”

Data Sheet 1_Association between the American Heart Association’s New Life’s Essential 8 Metrics and Depression Symptom in U.S General Adults, Finding from NHANES 2005-2018.docx... by Zhuoer Ruan (20278014)

“…The study revealed that individuals with positive scores in both individual and total LE8 metrics were less likely to experience depressive symptoms compared to those with negative scores. Furthermore, a significant negative linear trend was observed, showing that as the overall number of favorable LE8 scores increased, the likelihood of depressive symptoms decreased.…”