Showing 181 - 200 results of 1,931 for search '(( significant decrease decrease ) OR ( significantly mediate decrease ))~', query time: 0.45s Refine Results
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    Data for Fig 6D. by Xiaohua Zhang (350570)

    Published 2024
    “…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (<sup>132</sup>DVAADAAAEAAAAE<sup>145</sup>) mutated strain (PRV-UL4<sup>mut</sup>) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”
  13. 193

    Data for Fig 5D. by Xiaohua Zhang (350570)

    Published 2024
    “…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (<sup>132</sup>DVAADAAAEAAAAE<sup>145</sup>) mutated strain (PRV-UL4<sup>mut</sup>) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”
  14. 194

    Data for Figs 8A–8H, 9A–9K, 10A–10I. by Xiaohua Zhang (350570)

    Published 2024
    “…Further research showed that UL4 promoted the phosphorylation levels of SYK and JNK to enhance the ASC phosphorylation, which led to the increase of ASC oligomerization, thus promoting the activation of NLRP3 and AIM2 inflammasome and enhanced GSDMD-mediated pyroptosis. In <i>vivo</i> experiments further showed that PRV UL4 (<sup>132</sup>DVAADAAAEAAAAE<sup>145</sup>) mutated strain (PRV-UL4<sup>mut</sup>) infection did not lead to a significant decrease in viral titers at 12 h. p. i, but it induced lower levels of IL-1β, IL-18, and GSDMD-NT, which led to an alleviated inflammatory infiltration and pathological damage in the lungs and brains, and a lower death rate compared with wild-type PRV strain infection. …”
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