Table 1_Chemogenetic modulation of the rat locus coeruleus alters hippocampal noradrenaline release and modulates perforant path-evoked responses.docx حسب Sielke Caestecker (20749481)

"…</p>Results<p>In a significant number of rats (7/15) we found an increase in hippocampal NA release, field excitatory post synaptic potential (fEPSP) slope and population spike (PS) amplitude, indicating an increase in excitatory neurotransmission and neuronal output. 4/15 rats showed a decrease in NA release without changes in fEPSP slope or PS amplitude, and 4/15 showed no change in NA release.…"

Data Sheet 1_The impact of small food workshops management regulations on aflatoxin B1 in home-made peanut oil and the liver function of high-consumption area residents: an interru... حسب Jiangbo Lei (20457626)

"…The implementation of SFWMR was associated with a significant reduction in AFB₁ concentrations in HMPO, showing an immediate decrease of 2.865 μg/kg (P = 0.006) and a sustained annual reduction of 2.593 μg/kg (P = 0.034). …"

Data Sheet 1_Aleurone supplementation enhances the metabolic benefits of training in Standardbred mares: impacts on glucose-insulin dynamics and gut microbiome composition.pdf حسب Berit Boshuizen (3747655)

"…</p>Results<p>Training alone: Training significantly improved OGTT parameters by decreasing Maximum_insulin (P = 0.005) and AUC_insulin (P = 0.001), while increasing Time to peak_insulin (P = 0.03), indicating enhanced insulin sensitivity. …"

RICTOR regulates UGCG expression via transcription factor Zinc Finger X-linked (ZFX). حسب Mohammad Nafees Ansari (22232505)

"…<b>(T)</b> Tumor growth kinetics recorded a significantly higher growth of MCF-7_ZFX^OE (mean ± SEM, <i>n</i> = 4-6) than MCF-7_VECT^OE tumors. …"

Table 1_Functional characterization of endocytic signals in the SynDIG/PRRT family members SynDIG1 and SynDIG4 in heterologous cells and neurons.xlsx حسب David J. Speca (20601326)

"…Loss of SynDIG4, and the subsequent decrease in extra-synaptic GluA1, has been found to significantly impact synaptic plasticity in the hippocampus. …"

Data Sheet 1_Metabolomics analysis of aqueous humor from patients with high-myopia complicated nuclear cataract.pdf حسب Qiuyi Huo (21398225)

"…Univariate and multivariate analyses were performed to identify differential metabolites with potential biological significance.</p>Results<p>For HMnC patients, the level of glutathione was decreased, whereas arginine, tyrosine, and tryptophan were more abundant in AH. …"

Data Sheet 2_Metabolomics analysis of aqueous humor from patients with high-myopia complicated nuclear cataract.pdf حسب Qiuyi Huo (21398225)

"…Univariate and multivariate analyses were performed to identify differential metabolites with potential biological significance.</p>Results<p>For HMnC patients, the level of glutathione was decreased, whereas arginine, tyrosine, and tryptophan were more abundant in AH. …"

DataSheet1_Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis.docx حسب K. Melissa Hallow (9248960)

"…</p>Results<p>The model confirmed the significant role of ET_B in ET-1 clearance. …"

Data Sheet 1_Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis.docx حسب Rita Spathis (187690)

"…We propose that inhibiting complement receptor 1/2/3 (CR 1/2/3)-mediated phagocytosis and endosomal TLR 7/8/9 signaling pathways may decrease immune and inflammatory responses while simultaneously increasing the availability of AAV virus for muscle transduction.…"

Data Sheet 1_Mechanisms of c-Fos regulation of mTOR signaling via ERα/β in abnormal lipid metabolism of granulosa cells in PCOS.pdf حسب Xinyi Chen (491760)

"…TG content was elevated in the c-Fos-upregulated group compared to controls, but no significant changes were observed in TC levels. Co-culture of granulosa cells with increasing concentrations of 17β-estradiol resulted in significantly higher ERα and ERβ expression, decreased p-mTOR/mTOR levels, and a reduction in TG content, while TC levels remained unchanged.…"

Data_Sheet_1_Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease.docx حسب Fahad Mubariz (16010003)

"…Using PD patients’ induced-pluripotent stem cells (iPSCs), we examined TFEB activity and regulation of the ALP in dopaminergic neuronal cultures generated from iPSC lines harboring heterozygous GBA1 mutations and the CRISPR/Cas9-corrected isogenic controls. Our data showed a significant decrease in TFEB transcriptional activity and attenuated expression of many genes in the CLEAR network in GBA1 mutant neurons, but not in the isogenic gene-corrected cells. …"

Table 1_Unexpected estradiol decline during ovarian stimulation monitoring affects cumulative live birth.docx حسب Haixiao Chen (12565087)

"…Mediation analyses showed that the decrease in CLBR was primarily due to decreased embryo yield in both unmatched (76.5% mediated, P = 0.002) and matched cohorts (72.5% mediated, P = 0.01). …"

Data_Sheet_1_Effects of household solid fuel use on sarcopenia in middle-aged and older adults: evidence from a nationwide cohort study.docx حسب Shaohui Su (19779057)

"…Switching to clean cooking fuels significantly reduced sarcopenia risk (HR 0.766, 95% CI 0.599–0.979). …"

Supplementary file 1_Potential antitumoral effects of SRPK1 inhibition through modulation of VEGF splicing in pituitary somatotroph tumoral cells.jpeg حسب Donatella Treppiedi (10146335)

"…Moreover, SRPIN340 significantly decreased both transcript (-56.3 (38.6)%, p<0.01 vs control cells) and protein levels (-33.5 (3.4)%, p<0.05 vs control cells) of the pro-survival VEGF164a isoform. …"

Image 1_Potential antitumoral effects of SRPK1 inhibition through modulation of VEGF splicing in pituitary somatotroph tumoral cells.jpg حسب Donatella Treppiedi (10146335)

"…Moreover, SRPIN340 significantly decreased both transcript (-56.3 (38.6)%, p<0.01 vs control cells) and protein levels (-33.5 (3.4)%, p<0.05 vs control cells) of the pro-survival VEGF164a isoform. …"

Data Sheet 1_Effect of acupuncture on cognitive impairment induced by sleep deprivation in animal models: a preclinical systematic review and meta-analysis.docx حسب Chang Liu (35901)

"…Background<p>Sleep deprivation (SD) has been associated with cognitive deficits, mediated by mechanisms such as neuroinflammation and oxidative stress. …"

Image 2_Effect of acupuncture on cognitive impairment induced by sleep deprivation in animal models: a preclinical systematic review and meta-analysis.tif حسب Chang Liu (35901)

"…Background<p>Sleep deprivation (SD) has been associated with cognitive deficits, mediated by mechanisms such as neuroinflammation and oxidative stress. …"

Image 1_Effect of acupuncture on cognitive impairment induced by sleep deprivation in animal models: a preclinical systematic review and meta-analysis.tif حسب Chang Liu (35901)

"…Background<p>Sleep deprivation (SD) has been associated with cognitive deficits, mediated by mechanisms such as neuroinflammation and oxidative stress. …"

Table 1_Inverse association between triglyceride–glucose index and maximal oxygen uptake in US young and middle-aged population: a cross-sectional study.docx حسب Bin Zhang (64682)

"…</p>Conclusions<p>In the US young and middle-aged population, the TyG index was significantly adversely associated with VO₂max levels. …"

Image 5_Unexpected estradiol decline during ovarian stimulation monitoring affects cumulative live birth.png حسب Haixiao Chen (12565087)

"…Mediation analyses showed that the decrease in CLBR was primarily due to decreased embryo yield in both unmatched (76.5% mediated, P = 0.002) and matched cohorts (72.5% mediated, P = 0.01). …"