Table 5_Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort.xlsx by Qingzhi Zhai (21265412)

“…Metabolomics analysis revealed significantly elevated levels of the inflammatory mediator Prostaglandin E2 (PGE2) in CC samples. …”

Table 1_Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort.xlsx by Qingzhi Zhai (21265412)

“…Metabolomics analysis revealed significantly elevated levels of the inflammatory mediator Prostaglandin E2 (PGE2) in CC samples. …”

Table 4_Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort.xlsx by Qingzhi Zhai (21265412)

“…Metabolomics analysis revealed significantly elevated levels of the inflammatory mediator Prostaglandin E2 (PGE2) in CC samples. …”

Table 2_Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort.xlsx by Qingzhi Zhai (21265412)

“…Metabolomics analysis revealed significantly elevated levels of the inflammatory mediator Prostaglandin E2 (PGE2) in CC samples. …”

Data Sheet 1_Exogenous putrescine modulates variety-specific cadmium tolerance in wheat seedlings: synergistic roles of antioxidant defense and physiological homeostasis.pdf by Dandan Zhong (388523)

“…Introduction<p>Cadmium (Cd) contamination in farmland is a significant environmental issues affecting crop yields. …”

Data Sheet 1_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”

Data Sheet 4_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.pdf by Yingchao Wu (2870927)

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”

Data Sheet 1_Parent soil type modulates biochar and mowing effects on soil microbial communities in karst region.docx by Xun Yi (2167936)

“…Biochar significantly increased the relative abundances of dominant bacterial phyla-Proteobacteria and Actinobacteria–while decreasing Chloroflexi in red soil, with minimal changes observed in calcareous soil. …”

Data Sheet 3_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”

Data Sheet 2_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…”

Summertime bedroom overheating in un-airconditioned UK urban apartments: factors influencing subjective and objective sleep outcomes by Iuliana Hartescu (1249374)

“…</p><p dir="ltr">Results: Night-time (22.00-07.00) bedroom temperatures rose significantly during HN (range BL = 17.5-26.4°C; HN = 22.0-29.3°C, p<0.001) with thermal comfort (p<0.001), ‘restfulness’ (p<0.001) and TST (p<0.05) significantly decreasing, while heat-related sleep disturbance significantly increased (p<0.001). …”

Table 1_Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride.docx by Gejing Li (18948236)

“…Experimental validation confirmed that SH (50–200 μM) significantly inhibited GS activity and GLUL expression and consequently decreased glutamine levels in RA-FLS. …”

Data Sheet 1_Correlation between cortical morphology and synaptic-associated proteins levels in poststroke aphasia: a pilot study.docx by Yun Cao (111731)

“…Correlation analysis was conducted among factors with significant group differences.</p>Results<p>Compared with HCs, PSA patients had significantly altered serum levels of α-SYN, BDNF, TrkB, CREB, and GAP-43. …”

Table 1_Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.docx by Dongsheng Wu (2469307)

“…As bioactive compounds exhibiting dual antioxidant and anti-inflammatory properties, polyphenolic derivatives demonstrate significant therapeutic potential through multimodal mechanisms targeting COPD pathophysiology - particularly in modulating redox homeostasis (GSH/GSSG ratio elevation), attenuating NF-κB-mediated inflammatory cascades, and enhancing respiratory function parameters (FEV1 improvement ≥12% from baseline). …”

Data Sheet 1_Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.zip by Dongsheng Wu (2469307)

“…As bioactive compounds exhibiting dual antioxidant and anti-inflammatory properties, polyphenolic derivatives demonstrate significant therapeutic potential through multimodal mechanisms targeting COPD pathophysiology - particularly in modulating redox homeostasis (GSH/GSSG ratio elevation), attenuating NF-κB-mediated inflammatory cascades, and enhancing respiratory function parameters (FEV1 improvement ≥12% from baseline). …”

Image 1_T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Rα targeting.jpeg by Jelena Pesic (21216791)

“…Chronic exposure to T2 cytokines following RV infection significantly decreased TSLP and IFNλ1 but increased IFNβ, specifically in asthmatic BECs.…”

Effects of contralateral noise on CAEP (Lee et al., 2025) by Donguk Lee (21628297)

“…The presentation of contralateral noise had a significant effect on P1 and N1 latencies, both of which decreased. …”

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …”

Image 1_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …”

Image 1_5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation.pdf by Jinque Luo (9645983)

“…</p>Results<p>5-DR treatment significantly reduced lung edema, inflammatory cell infiltration in mice with LPS burden, and reduced the levels of inflammatory mediators like interleukin-1β in the mice and in LPS-stimulated J774A.1 mouse macrophages. …”