بدائل البحث:
significantly mediated » significantly predicted (توسيع البحث), significantly related (توسيع البحث), significantly reduced (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
mediated decrease » mediated defense (توسيع البحث), estimated decrease (توسيع البحث), mediated diseases (توسيع البحث)
significantly mediated » significantly predicted (توسيع البحث), significantly related (توسيع البحث), significantly reduced (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
mediated decrease » mediated defense (توسيع البحث), estimated decrease (توسيع البحث), mediated diseases (توسيع البحث)
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621
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622
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623
TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts
منشور في 2025"…TRIM16 knockdown reduced autophagosomes at the plasma membrane and decreased IL6 secretion from CAFs. These findings uncover key molecular components involved in autophagy-mediated IL6 secretion in CAFs and suggest potential therapeutic targets for HNSCC.…"
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624
Table 1_Muscle quality index and hyperuricemia: adipose tissue as a mediator.docx
منشور في 2025"…</p>Conclusion<p>This study reveals a significant negative correlation between MQI and hyperuricemia, mediated by adipose tissue. …"
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625
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626
Supporting data for "The Mediating and Moderating Factors in the Association between Tooth Loss and Cognitive Decline"
منشور في 2025"…<p dir="ltr">Dementia has emerged as significant public health concerns, with Alzheimer's disease (AD) constituting the predominant subtype. …"
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627
Source data for Fig 2.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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628
Source data for lung metabolomics.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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629
Source data for Fig 5.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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630
Source data for Fig 1.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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631
Flow cytometry gating strategy for MDSC.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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632
Source data for Fig 3.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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633
Source data for Fig 4.
منشور في 2025"…Our <i>ex vivo</i> inhibition experiment revealed that L-kynurenine, a product of tryptophan metabolism, inhibits T-cell proliferation and induces T-cell apoptosis, further suppressing T-cell mediated responses against bacteria. Importantly, when we knocked out the <i>Ido1</i> gene or inhibited IDO1 expression using a specific inhibitor 1-MT in mice, we observed a significant enhancement in T-cell mediated responses against hv<i>Kp</i>. …"
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634
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635
S5 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"
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636
S1 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"
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637
S7 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"
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638
S3 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"
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639
S2 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"
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640
S4 File -
منشور في 2024"…</p><p>Results</p><p>CY and DEX significantly reduced the immune function in DNFB-induced sensitized mice, as indicated by decreased thymus and spleen indices, MLN enlargement, intestinal sIgA content, and ear swelling degree. …"