Changes to the host transcriptome during infection. حسب Stefan Bresson (20623940)

Oligonucleotides used for vector clone. حسب Mingyi Xu (5575871)

"…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …"

Information of chemicals used in this study. حسب Mingyi Xu (5575871)

"…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …"

Oligonucleotides used for amplification. حسب Mingyi Xu (5575871)

"…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …"

Candidate genes by Genome-wide CRISPR Screen. حسب Mingyi Xu (5575871)

"…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …"

Included studies basic characteristics. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for FVC. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

All data extracted. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for TNF- حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Bias risk assessment of included studies. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for hs-CRP. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for IL-6. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

The incidence rate of adverse reactions. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

The PRISMA study flowchart. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for FEV1/FVC. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for clinical efficacy. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for FEV1. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

The excluded and included studies were listed. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for PaCO₂. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"

Forest plot for PaO₂. حسب Xuqin Du (8803772)

"…QJHTD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = –7.47, 95% CI [–10.59, –4.34], <i>p </i>= 0.000), IL-6 (MD = -4.33, 95% CI [–6.17, –2.48], <i>p </i>= 0.000), and hs-CRP (MD = –9.11, 95% CI [–11.02, –7.20], <i>p </i>= 0.000). …"