Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of <i>Muc4</i> حسب Zhong-Tang Li (21183172)

"…Moreover, RNA interference-mediated suppression of MUC4 significantly attenuated transforming growth factor-β induced ECM production by mouse tubular epithelial cells. …"

Table 1_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx حسب Yingchao Wu (2870927)

"…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…"

Image_2_A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.TIF حسب Kaijie Ma (6065156)

"…Further, the amplitudes of mAHP were significantly decreased in male BDNF^+/Met mice only, which were mediated by the downregulation of Kcnn2 encoding small conductance calcium-activated potassium channel 2 (SK2). …"

Image_1_A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex.TIF حسب Kaijie Ma (6065156)

"…Further, the amplitudes of mAHP were significantly decreased in male BDNF^+/Met mice only, which were mediated by the downregulation of Kcnn2 encoding small conductance calcium-activated potassium channel 2 (SK2). …"

Data Sheet 1_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx حسب Yingchao Wu (2870927)

"…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…"

Data Sheet 4_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.pdf حسب Yingchao Wu (2870927)

"…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…"

Data Sheet 1_Parent soil type modulates biochar and mowing effects on soil microbial communities in karst region.docx حسب Xun Yi (2167936)

"…Biochar significantly increased the relative abundances of dominant bacterial phyla-Proteobacteria and Actinobacteria–while decreasing Chloroflexi in red soil, with minimal changes observed in calcareous soil. …"

Data Sheet 3_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx حسب Yingchao Wu (2870927)

"…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…"

Data Sheet 2_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx حسب Yingchao Wu (2870927)

"…Furthermore, SSA displayed inhibitory effects on tumor growth with minimal toxicity in animal studies, accompanied by activated biomarkers of cellular senescence and decreased expression of p-Akt and p-PI3K.</p>Conclusion<p>Taken together, based on the preliminary results of network analysis and further experimental validation, this study revealed that SSA significantly induced cell cycle arrest and senescence, and the inhibition of ROS-mediated PI3K/Akt pathway may be the potential mechanism in this process.…"

Data Sheet 1_Mechanisms of c-Fos regulation of mTOR signaling via ERα/β in abnormal lipid metabolism of granulosa cells in PCOS.pdf حسب Xinyi Chen (491760)

"…TG content was elevated in the c-Fos-upregulated group compared to controls, but no significant changes were observed in TC levels. Co-culture of granulosa cells with increasing concentrations of 17β-estradiol resulted in significantly higher ERα and ERβ expression, decreased p-mTOR/mTOR levels, and a reduction in TG content, while TC levels remained unchanged.…"

Data Sheet 1_Photodynamic inactivation of Staphylococcus aureus with rose bengal reduces superantigen activity.docx حسب Patrycja Ogonowska (5644274)

"…Across in vitro, ex vivo, and murine in vivo models, RB-mediated aPDI significantly decreased S. aureus viability and markedly attenuated the expression and activity of staphylococcal enterotoxins. …"

Image 1_5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation.pdf حسب Jinque Luo (9645983)

"…</p>Results<p>5-DR treatment significantly reduced lung edema, inflammatory cell infiltration in mice with LPS burden, and reduced the levels of inflammatory mediators like interleukin-1β in the mice and in LPS-stimulated J774A.1 mouse macrophages. …"

Data Sheet 1_5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation.pdf حسب Jinque Luo (9645983)

"…</p>Results<p>5-DR treatment significantly reduced lung edema, inflammatory cell infiltration in mice with LPS burden, and reduced the levels of inflammatory mediators like interleukin-1β in the mice and in LPS-stimulated J774A.1 mouse macrophages. …"

Table 1_5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation.docx حسب Jinque Luo (9645983)

"…</p>Results<p>5-DR treatment significantly reduced lung edema, inflammatory cell infiltration in mice with LPS burden, and reduced the levels of inflammatory mediators like interleukin-1β in the mice and in LPS-stimulated J774A.1 mouse macrophages. …"

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif حسب Lixuan Yang (7331786)

"…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …"

Image 1_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif حسب Lixuan Yang (7331786)

"…</p>Results<p>In rats with CSVD and depression, PY significantly increased body weight; alleviated depression-like behaviors; and decreased the levels of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in both serum and hippocampus. …"

Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats حسب Hatice Colak (20773009)

"…Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses.</p> <p>BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. …"

Data Sheet 1_NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.pdf حسب Stephanie DeStefano (15457187)

"…</p>Results<p>In comparison to WT mice, NLRP3^-/- mice exhibited significantly enhanced AHR and mucus production, while eosinophilic airway inflammation was comparable. …"

Data Sheet 1_Correlation between cortical morphology and synaptic-associated proteins levels in poststroke aphasia: a pilot study.docx حسب Yun Cao (111731)

"…Correlation analysis was conducted among factors with significant group differences.</p>Results<p>Compared with HCs, PSA patients had significantly altered serum levels of α-SYN, BDNF, TrkB, CREB, and GAP-43. …"

Table 6_UV-C and hydration state drive pulsed light-induced proteome damage in Bacillus pumilus spores.xlsx حسب Imed Dorbani (21031028)

"…Proteomic changes were analyzed using mass spectrometry to identify proteins with decreased abundance after treatment.</p>Results<p>PL treatment induced a significantly greater proteomic alteration compared to UV-C, particularly in spores suspended in water, where the number of proteins with decreased abundance was ~6-fold higher than in spores sprayed on a polystyrene surface. …"