Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway by Qiuxia Liao (21507933)

“…Notably, all results were statistically significant. Overall, our findings revealed that dexmedetomidine may mitigate inflammation, oxidative stress, and renal dysfunction in mice with SAKI by upregulating the Pink1/Park2-mediated autophagy pathway. …”

Data Sheet 1_Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells.docx by Na Tian (296333)

“…</p>Conclusion<p>HU-308 demonstrates significant anti-inflammatory effects in AIA by restoring Th17/Treg balance and reducing joint damage. …”

Table 4_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Data from: Temporal niche partitioning by nocturnal arboreal mammals increases the modularity of plant-frugivore networks in a fragmented subtropical landscape by Wande Li (12480883)

“…Island area positively predicted nocturnal interaction richness and its proportional contribution, whereas isolation had no significant effect. Incorporating nocturnal interactions increased network modularity and decreased nestedness, indicating temporal niche partitioning, while connectance remained unchanged. …”

Table 1_High humidity environment increases FBG by impairing the intestinal barrier.xlsx by Yao Wang (102387)

“…Introduction<p>Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. …”

Table 2_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 2_High humidity environment increases FBG by impairing the intestinal barrier.docx by Yao Wang (102387)

“…Introduction<p>Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. …”

Table 3_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 1_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.xlsx by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 3_High humidity environment increases FBG by impairing the intestinal barrier.xlsx by Yao Wang (102387)

“…Introduction<p>Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. …”

Table 6_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Data Sheet 1_High humidity environment increases FBG by impairing the intestinal barrier.zip by Yao Wang (102387)

“…Introduction<p>Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. …”

Table 5_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Table 8_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv by Zhenyu Zhao (737165)

“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”

Summertime bedroom overheating in un-airconditioned UK urban apartments: factors influencing subjective and objective sleep outcomes by Iuliana Hartescu (1249374)

“…</p><p dir="ltr">Results: Night-time (22.00-07.00) bedroom temperatures rose significantly during HN (range BL = 17.5-26.4°C; HN = 22.0-29.3°C, p<0.001) with thermal comfort (p<0.001), ‘restfulness’ (p<0.001) and TST (p<0.05) significantly decreasing, while heat-related sleep disturbance significantly increased (p<0.001). …”

Data Sheet 1_Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites and hormones, in addition to nitrogen excretion.xlsx by Matthieu Clauss (9769343)

“…Urinary nitrogen excretion over the 24 hours following drink ingestion was significantly higher in PRO (p<0.001), particularly between 2 to 8 hours after intake (p<0.001).…”

Data Sheet 1_Allicin ameliorates acute myocardial infarction in rats by modulating calcium homeostasis in cardiomyocytes through the induction of hydrogen sulfide production.docx by Weiyu Liu (3879487)

“…</p>Results<p>The results indicate that allicin significantly enhanced cardiac function, raised H₂S levels in myocardial tissue and serum, reduced necrosis tissue size, decreased myocardial enzyme levels, and improved myocardial pathological changes. …”

DataSheet1_The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner.docx by Mehri Hajiaghayi (19822665)

“…Nebivolol-treated β₂-knockout memory Th cells showed significant inhibition of β₂-AR-mediated signaling, evidenced by the absence of IL-17A suppression compared to controls. …”

Supporting data for “Androgen receptor modulates chemotherapy response in breast cancer” by Chanping You (9067448)

“…Chromatin immunoprecipitation (ChIP) sequencing identified 1,209 AR-regulated genes, with gene ontology (GO) analysis highlighting significant enrichment of ubiquitin-related genes. qPCR validation pinpointed TRIM37, an AR-regulated E3 ligase, as a mediator of RB1 degradation. …”

Table 1_Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease.docx by Kajal Kamboj (12769602)

“…A significant increase in mRNA expression of vitamin D-responsive genes (cathelicidin, IL-10, VDR, and CYP27B1) was observed. …”