Table 1_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.xlsx by Rong Su (2210740)

“…Risk model-based clustering of HCC samples revealed that cluster 2, characterized by a higher risk score, correlated with a poorer prognosis and reduced immune and stromal scores. In vitro, the overexpression of miR-4739 in Huh-7 cells significantly induced SPP1⁺ macrophages, and the culture medium derived from SPP1⁺ macrophages further promoted the proliferation and migration of Huh-7 cells. …”

Supplementary file 3_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc by Haozhe Li (6399116)

“…However, it exerted no significant impact on the levels of LVIDs and LVIDd in the model.…”

Supplementary file 1_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc by Haozhe Li (6399116)

“…However, it exerted no significant impact on the levels of LVIDs and LVIDd in the model.…”

Table 1_The mechanism of Guanxin Qiwei dropping pills target Dubosiella to improve atherosclerosis.docx by Yuanhong Liao (359147)

“…Fingerprint analysis showed the consistency and stability of the quality of GXQW. Additionally, GXQW reduced total cholesterol (TC) and triglyceride (TG) levels, decreased the concentrations of inflammatory cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1β), suppressed malondialdehyde (MDA) activity, and elevated superoxide dismutase (SOD) levels. …”

Supplementary file 2_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc by Haozhe Li (6399116)

“…However, it exerted no significant impact on the levels of LVIDs and LVIDd in the model.…”

Data Sheet 1_Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells.docx by Na Tian (296333)

“…</p>Conclusion<p>HU-308 demonstrates significant anti-inflammatory effects in AIA by restoring Th17/Treg balance and reducing joint damage. …”

Data Sheet 1_The protective effects and mechanisms of rosmarinic acid against Pseudomonas aeruginosa infection in Caenorhabditis elegans.doc by Ying Zhang (40767)

“…RA treatment at concentrations of 100-300 mg/L dose-dependently reduced the number of PA14 colonies in the nematodes, prolonged the lifespan of the infected nematodes, improved behavioral impairments, decreased lipofuscin and ROS accumulation, and alleviated oxidative stress. …”

Supplementary Material for: Phosphorus restriction prevents rapamycin-induced kidney damage in rats by Raya A.I. (19823163)

“…Results: When compared with placebo, rapamycin administration to Nx rats resulted in significant increases in IN (4.17±0.74 vs 1.51±0.53 %) and TD (14.45±1.51 vs 8.61±1.83 %). …”

Image 3_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 5_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture by Paul Yancey (14354982)

“…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …”

Data Sheet 1_A circular tri-trophic system incorporating plants, fish, and insects turns waste into a resource: case study with the cultivation of cucumber.docx by Efi Levizou (21298322)

“…Conversely, CAP resulted in a decline in nutrient levels in irrigation water relative to HP and DCAP, which led to significantly decreased leaf concentrations of potassium and phosphorus (2.5 and 1.5 times lower than HP, respectively, by the end of the experiment). …”

Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario by Karoliny Nune Santos (21752603)

“…HUVECs exposed to PE plasma and treated with MCC950 demonstrate: (1) activation by plasma-derived factors of (2) the NLRP3 pathway <i>via</i> TLR4/NF-κB; (3) however, (4) MCC950 blocks NLRP3-ASC complex oligomerization. This results in (5) reduced caspase-1 levels, (6) decreased IL-1β levels, (7) normalization of ROS levels, among (8) other consequences that together ultimately lead to (9) a controlled inflammatory response.…”

Image 2_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.jpeg by Zebanuer Yuemaierjiang (22702064)

“…</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Supplementary Material for: DOT1L regulates cellular senescence during the progression from acute kidney injury to chronic kidney disease via the micro-222-5p/WNT9B signaling pathw... by figshare admin karger (2628495)

“…Results: The results demonstrated that in vivo inhibition of DOT1L significantly reduced cellular senescence and improved renal tubular injury and interstitial fibrosis. …”

Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx by Zebanuer Yuemaierjiang (22702064)

“…</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Image 1_The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.tif by Yan Zhang (8098)

“…Compared to the HC, long-term increased activity was still present in the right frontal operculum cortex, right insular cortex, right inferior frontal gyrus (pars opercularis), and right frontal pole despite the effectiveness of MVD surgery. In contrast, MVD significantly reduced the area of aberrant activation regions, particularly in the operculo-insular cortex, and also normalized cerebellar abnormalities.…”