Table 2_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx by Ning An (618997)

“…Metabolic risks, particularly high systolic blood pressure, were significant contributors to HHD-related mortality and DALYs, with a pronounced impact in high-SDI regions. …”

Table 1_Elucidating the causal relationship between 486 genetically predicted blood metabolites and the risk of gastric cancer: a comprehensive Mendelian randomization analysis.xls... by Lei Qian (292302)

“…</p>Results<p>The MVMR analysis revealed a significant association between genetically predicted elevated levels of tryptophan (odds ratio [OR] = 0.523, 95% confidence interval [CI] = 0.313–0.872, p = 0.013), nonadecanoate (19:0) (odds ratio [OR] = 0.460, 95% confidence interval [CI] = 0.225–0.943, p = 0.034), and erythritol (odds ratio [OR] = 0.672, 95% confidence interval [CI] = 0.468–0.930, p = 0.016) with a decreased risk of gastric cancer. …”

C2CD3 is crucial for the localization of the LDR and DISCO complexes. by Eloïse Bertiaux (5309927)

“…Centriole length is significantly reduced in siC2CD3 (<i>n</i> = 61, 200 ± 48 nm) compared to siCTRL (<i>n</i> = 63, 437 ± 52 nm); ****<i>P</i> < 0.0001, unpaired t <i>t</i>est, 4 experiments. …”

Supporting data for “Androgen receptor modulates chemotherapy response in breast cancer” by Chanping You (9067448)

“…Chromatin immunoprecipitation (ChIP) sequencing identified 1,209 AR-regulated genes, with gene ontology (GO) analysis highlighting significant enrichment of ubiquitin-related genes. qPCR validation pinpointed TRIM37, an AR-regulated E3 ligase, as a mediator of RB1 degradation. …”

Revisiting the association between sodium-glucose cotransporter-2 inhibitors and the risk of neoplasm in patients with type 2 diabetes: new insights from an updated systematic revi... by Yiran Wang (1492303)

“…</p> <p>A total of 53 RCTs with 126,232 participants were included. No significant differences were found for the risk of overall neoplasm (RR = 1.08, 95% CI: 0.99 to 1.19, I² = 23%) in patients with SGLT-2i treatment compared with non-users. …”

<b>Selective Reduction of Ca</b>^{<strong>2+</strong>}<b>-Independent Phospholipase A</b>_{<strong>2</strong>}<b>b</b><b> (iPLA</b>_{<strong>2</strong>}<b>b... by Abdulaziz Almutairi (9584768)

“…These outcomes are associated with a significant reduction in T1D. Further, inhibition of select proinflammatory lipid signaling pathways reduces M1-like MF polarization and adoptive transfer of M2-like MF reduces NOD T1D incidence, suggesting a mechanism by which iDLs impact T1D development. …”

DataSheet1_The β2-adrenergic biased agonist nebivolol inhibits the development of Th17 and the response of memory Th17 cells in an NF-κB-dependent manner.docx by Mehri Hajiaghayi (19822665)

“…Nebivolol-treated β₂-knockout memory Th cells showed significant inhibition of β₂-AR-mediated signaling, evidenced by the absence of IL-17A suppression compared to controls. …”

TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts by Thuc Ly (12832686)

“…We demonstrate that SEC22B, SNAP23, VAMP3, and STX4 colocalize with LC3B, IL6, and TRIM16 in CAFs. TRIM16 knockdown reduced autophagosomes at the plasma membrane and decreased IL6 secretion from CAFs. …”

Table 1_Organic and inorganic fertilizers modulate the response of the soil microbiome to salinity stress.docx by Halima Malal (21570602)

“…Furthermore, NPK fertilization increased bacterial network complexity but decreased its stability. This study underscores the significance of employing vermicompost to improve the health of saline soils. …”

<b>Dielectric Properties of Composite PZT Films with Distinct Phase Transition Temperatures via Aerosol Deposition</b> by Ye-Ji Son (20656475)

“…As shown in <b>Figure 6(b)</b>, annealing significantly enhanced the dielectric properties of the composite PZT film. …”

C2CD3 regulates spatial organization of centriole architecture. by Eloïse Bertiaux (5309927)

“…<b>(C)</b> SAS6 length is significantly reduced in siC2CD3 (<i>n</i> = 28, 68 ± 25 nm) vs. siCTRL (<i>n</i> = 45, 104 ± 36 nm), ****<i>P</i> < 0.0001. …”

Impacts of winter climate change on northern forest understory carbon dioxide exchange determined by reindeer grazing by Noora Kantola (14263490)

“…To understand how reindeer grazing, coupled with changes in snow depth affects CO₂ exchange, we used recent snow treatments (ambient, reduced, and increased snow depth) combined with 25- and 55-year-old reindeer exclusions and the adjacent grazed areas in boreal and subarctic Scots pine forests that are main winter pastures for reindeer/caribou and cover a significant portion of boreal and subarctic landscapes. …”

Data Sheet 1_Real-world analysis of leuprorelin acetate microspheres-based neoadjuvant therapy for patients with high-risk prostate cancer.docx by Changde Fu (20899748)

“…Testosterone showed a decreased tendency after neoadjuvant therapy, but without statistical significance (P=0.185). …”

CDCP1 regulates CDA and hENT1 expression through c-Src/PKCδ signaling pathway. by Kun-Lin Hsieh (11401919)

“…Data are presented as mean ± SD with statistical significance indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001.…”

Data Sheet 1_Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.pdf by Dilara Yılmaz (19710658)

“…We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. …”

Figures_Acoustic_DEWESOFTX software_Dr. Arun Y Patil.zip by Dr Arun Y Patil (20644574)

“…This study highlights the significance of vibration control using bio-inspired damping materials and provides valuable insights into the dynamic response of multi-stage structures. …”

Data Sheet 1_Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.docx by Nikola Habek (21178259)

“…In mice, centrally applied UGN and its analog linaclotide, affecting the hypothalamus, induced both acute and chronic activation of BAT, which decreases the plasma glucose concentration. However, in obesity, proUGN expression was reduced in the human hypothalamus, suggesting reduced postprandial glucose consumption in BAT. …”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…(middle): Effects of MYLK4 knockdown in AD-RD cells. siMYLK4 treatment reduced self-renewal capacity and decreased SALL2 and pT43-CDKAL1 protein levels. …”

Table1_CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence.xlsx by Zijian Qiu (17560477)

“…Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.…”

Image 1_Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation.tif by Shuxiao Chen (7339340)

“…</p>Results<p>ATL-I inhibited the dilatation of the abdominal aorta and decreased the incidence of AAA. ATL-I alleviated the infiltration of macrophages in the adventitia and reduced the levels of proinflammatory factor IL-1β and IL-6 in the aorta and circulatory system, while increasing the expression of anti-inflammatory factor IL-10. …”